Risks of malignant lymphoma in rheumatoid arthritis patients receiving methotrexate-alone and in combination therapy compared with the general population: A study based on a Japanese medical claims database [0.03%]
日本基于医疗理赔数据库的类风湿关节炎患者仅使用甲氨蝶呤或联合用药与普通人群恶性淋巴瘤风险的对比研究
Ryo Inose,Arisa Nakamura,Rina Omi et al.
Ryo Inose et al.
Objective: The risk of malignancy in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) and biological disease-modifying antirheumatic drug (bDMARD) combination therapy is unknown. This study aimed to...
Risk factors for amiodarone-induced liver injury: A retrospective analysis of medical records [0.03%]
胺碘酮致肝损伤的危险因素：病例对照研究
Hinoo Nagai,Takahiro Amemiya,Hiroshi Suzuki
Hinoo Nagai
Objective: This study identified risk factors for drug-induced liver injury (DILI) based on patient information before the administration of amiodarone. M...
Differential effects on renal function and glucose metabolism of renal dependent bezafibrate and non-renal dependent pemafibrate in patients with hypertriglyceridemia [0.03%]
肾依赖性苯扎贝特和非肾依赖性佩马贝特对高甘油三酯血症患者肾功能和糖代谢的差异化效应
Mana Nishida,Takeshi Horio,Yusuke Fukuda et al.
Mana Nishida et al.
Objective: Among fibrates as triglyceride-lowering agents, bezafibrate and fenofibrate are predominantly renally excreted, while pemafibrate is mainly hepatically metabolized and biliary excreted. To elucidate possible di...
Voriconazole-induced visual abnormality based on drug interaction between voriconazole and esomeprazole: A case report [0.03%]
伏立康唑与埃索美拉唑相互作用引起视觉异常的个案报道
Zhouqian Jiang,Jia Li,Chengfei Zhao et al.
Zhouqian Jiang et al.
We report a case of voriconazole-induced visual abnormality based on drug interaction of voriconazole and esomeprazole, therapeutic drug monitoring, and optimal therapy. An 81-year-old male developed visual abnormality after the blood conce...
Acute pancreatitis caused by tigecycline and furosemide combination treatment and hypofibrinogenemia caused by tigecycline: A case report [0.03%]
替加环素联合呋塞米治疗导致急性胰腺炎和低纤维蛋白原血症：1例个案报告
Zhi Ke Li,Ping Zheng
Zhi Ke Li
Objective: We describe a case of acute pancreatitis (AP) and hypofibrinogenemia associated with drug treatment with the aim to increase awareness of uncommon yet possibly life-threatening adverse reactions of tigecycline ...
The characteristics and regulations of adaptive designs from 2008 to 2020: An overview of European Medicines Agency approvals [0.03%]
2008年到2020年欧洲药品管理局批准适应性设计特征及法规的概述
Xiaowei Huang,Jianbin Ma,Zhenzhen Lu et al.
Xiaowei Huang et al.
Objective: The aim of this study was to identify and characterize all European Medicines Agency (EMA) approvals derived from adaptive designs in clinical trials and to provide an update of the current status of these drug...
Acute myeloid leukemia after 10 years of azathioprine treatment for Crohn's disease [0.03%]
治疗克罗恩病的硫唑嘌呤治疗10年后发生急性髓系白血病病例报告
Trad Nouha,Mensi Asma,Boujelbene Nadia et al.
Trad Nouha et al.
Background: Azathioprine, which is an immunosuppressive agent commonly used for chronic inflammatory bowel disease, may be associated with an increased risk of certain cancers such as hematologic malignancies. ...
Effect of bevacizumab administered prior to transarterial chemoembolization on the therapeutic effects of lenvatinib given post-TACE in primary liver cancer patients [0.03%]
在肝动脉化疗栓塞前后贝伐单抗和仑伐替尼序贯治疗原发性肝癌的疗效观察
Zhongfeng Dang,Liwen Jiang,Fengping Huang
Zhongfeng Dang
Objective: To determine the therapeutic effects of lenvatinib combined with bevacizumab following transarterial chemoembolization (TACE) in patients with primary liver cancer. ...
Yaru Li,Yanan Jiang,Hui Zhang et al.
Yaru Li et al.
Acute lung injury (ALI) is a systemic inflammatory response syndrome in the lungs, with a high incidence and fatality rate of 30 - 40%. Despite the abundance of research on the pathogenesis of lung injury and the great progress that has bee...
Sub-therapeutic trimethoprim and sulfamethoxazole plasma concentrations during continuous venovenous hemofiltration in a patient with COVID-19 and pulmonary Pneumocystis jirovecii co-infection: A case report [0.03%]
连续性静脉至静脉血液滤过对COVID-19合并肺孢子菌肺炎患者体内小剂量复方新诺明血药浓度的影响：一例报告
Jos L M L le Noble,Norbert Foudraine,Kim C M van der Elst et al.
Jos L M L le Noble et al.
Objective: To investigate drug concentration of trimethoprim-sulfamethoxazole (TMP-SMX) using therapeutic drug monitoring (TDM) for severe Pneumocystis jirovecii (PJP) infection in a critically ill patient with COVID-19 r...