Comparison of SB17 and reference ustekinumab in healthy adults: A randomized, double-blind, single-dose, phase I study [0.03%]
SB17与参考乌司奴单抗在健康成年人中的比较：随机双盲单次给药一期研究
Hansol Jeong,Taeseung Kang,Jiyoon Lee et al.
Hansol Jeong et al.
Objective: This study compared the pharmacokinetic (PK) characteristics of SB17 (Samsung Bioepis, Incheon, Republic of Korea), a proposed biosimilar of ustekinumab (UST) against reference UST (Stelara, Janssen Biotech, Ho...
Pharmacokinetics and bioequivalence of tofacitinib 5 mg in healthy Korean male subjects [0.03%]
托法替尼5毫克在健康韩国男性受试者中的药代动力学和生物等效性研究
Ji-Hyoung Lee,Ji-Young Jeon,Kyungho Jang et al.
Ji-Hyoung Lee et al.
Objective: Tofacitinib is an oral Janus kinase (JAK) inhibitor marketed as an immunomodulator that can effectively treat rheumatoid arthritis. This study aimed to compare the pharmacokinetics and evaluate the bioequivalen...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2024 Mar;62(3):142-148. DOI:10.5414/CP204480 2024
Can non-renal clearance and/or bioavailability of drugs be assessed reliably in renal impairment studies with oral drug administration? [0.03%]
口服药物治疗时，肾功能不全研究能否可靠地评估非肾清除率和/或生物利用度？
Yichao Yu,Peter H Hinderling
Yichao Yu
Objective: The causes for the variable susceptibility of renal clearance (CLr) and bioavailability (F) of drugs in renal impairment are still unknown. We investigated whether the impact of chronic kidney disease (CKD) on ...
Hoarding of insulin and oral antidiabetics in the first phase of the COVID-19 pandemic: Regulatory actions taken to avoid shortage [0.03%]
COVID-19大流行初期囤积胰岛素和口服抗糖尿病药物的监管措施：避免短缺
Björn Zethelius,Anders Sundström,Kenneth Nordback et al.
Björn Zethelius et al.
Objective: To report on hoarding of prescribed medicines, with focus on insulins, in the early phase of the COVID-19 pandemic and on regulatory actions taken to avoid shortage. ...
Incidence and risk factors associated with augmented renal clearance in critically ill patients [0.03%]
重症患者肾小球滤过率增高的发生率和危险因素分析
Wen Xu,Chang-Jiang Wang,Jia-Zhen Xu
Wen Xu
Super-responder and clinical remission in patients with asthma on treatment with single biologic therapy or cycling therapy using dupilumab in a real-world setting [0.03%]
单用生物制剂或Dupixent轮换治疗下真实世界哮喘患者的超级应答者与临床缓解关系研究
Satoshi Hamada,Eriko Ogino,Hirotaka Yasuba
Satoshi Hamada
Background: Regarding the therapeutic target in asthma, super-responder status (SR) is a status without systemic corticosteroids. Recently, clinical remission (CR), being a status of prolonged absence of asthma symptoms w...
Network target theory and network pharmacology: Next generation drug research in medicine using AI models [0.03%]
网络靶标理论及网络药理学：利用AI模型进行医学下一代药物研究
Xiaojing Han,Chenghui Wang,Rui Li et al.
Xiaojing Han et al.
Maria Ganeva,Tanya Gancheva,Karen Manuelyan et al.
Maria Ganeva et al.
Objectives: Bullous pemphigoid (BP) is a rare, autoimmune, blistering disease in elderly patients that can be triggered by external factors including drugs. Drug-induced bullous pemphigoid (DIBP) does not always follow a ...
Pharmacokinetics and bioequivalence of two metoprolol succinate extended release tablets in healthy Chinese subjects under fasting and fed conditions [0.03%]
两种琥珀酸美托洛尔缓释片在健康受试者空腹及餐后条件下的药代动力学及生物等效性研究报告
Xiding Yang,Ronghua Zhu,Xiaojun Chen et al.
Xiding Yang et al.
Aims: The aims of this study were to evaluate and compare the pharmacokinetic profiles and establish bioequivalence of test and reference metoprolol succinate extended-release (ER) tablets in healthy Chinese subjects unde...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2024 Feb;62(2):101-108. DOI:10.5414/CP204474 2024
Methylobacterium infection-induced peritonitis in a patient with renal insufficiency: A case report and literature review [0.03%]
肾功能不全患者甲基杆菌感染性腹膜炎1例及文献复习
Huiyi Wu,Huanhao Chen,Wenfeng Wu et al.
Huiyi Wu et al.
Clinical pharmacists participated in the drug therapy of peritonitis caused by Methylobacterium infection in a patient with renal insufficiency. Based on the knowledge of clinical pharmacy, the patient's condition and laboratory parameters,...