Favipiravir pharmacokinetics in COVID-19 patients with moderate to severe kidney dysfunction: Lessons learned [0.03%]
favipiravir在中重度肾功能不全的COVID-19患者中的药代动力学特点：经验教训
Nursel Sürmelioğlu,Esra Demirtürk,Nazire Ateş Ayhan et al.
Nursel Sürmelioğlu et al.
Objective: There is limited information on favipiravir pharmacokinetics in critically ill patients and no studies on pharmacokinetics in patients with moderate and severe kidney dysfunction. The aim was to determine favip...
Alleviation of severe chronic arthritic pain using polyvalent immunoglobulins (KMP01): Two case reports [0.03%]
多价免疫球蛋白(KMP01)缓解重度慢性关节炎疼痛的两个病例报告
Barry G Woodcock,Peter Braun,Martin Gasser et al.
Barry G Woodcock et al.
Background: Treatment of arthritis is carried out using corticosteroids, methotrexate, sulfasalazine-like agents, and TNF-α-blocking agents such as infliximab and adalimumab. The disadvantages of these agents are high-co...
Network pharmacology analysis and molecular docking using the Chinese herbal agent WYHX formula (according to Yan Dexin): Management of coronary artery disease [0.03%]
基于严 Dexter 的化瘀行气方剂网络药理学分析及分子对接研究冠心病治疗功效
Zi-Yang Wang,Miao Zhou,Yong-Ning Sun et al.
Zi-Yang Wang et al.
Background: The therapeutic impact of the Wenyang Huoxue (WYXH) formula on coronary atherosclerotic heart disease (CHD) is well established, yet the precise mechanisms are currently not fully understood. This study provid...
Risk factors for infliximab-induced infusion reactions based on a retrospective study of medical information [0.03%]
基于对医疗信息的回顾性研究得出的英夫利昔雅致输液反应的风险因素分析
Takahiro Amemiya,Hiroshi Suzuki
Takahiro Amemiya
Objective: Infliximab is indicated for a wide range of diseases, and infusion reactions (IRs) have been reported after infliximab administration in 17.6% of patients in clinical practice. This study aimed to identify the ...
Activated charcoal helps in the diagnosis of dabigatran overdose: A case study [0.03%]
活性炭有助于达比加群中毒的诊断：一例报告
Ning Zhang,Weihua Niu,Haiqing Zhang et al.
Ning Zhang et al.
The direct-acting oral anticoagulant dabigatran etexilate (DE) targets thrombin and is used widely to prevent thromboembolism. A 79-year-old man was admitted to the Emergency Department due to anuria for 2 days. An urgent laboratory examina...
Degree of serum LDL cholesterol reduction by simvastatin and ezetimibe is dependent on baseline LDL cholesterol concentration but not on baseline values and changes in cholesterol synthesis and absorption parameters [0.03%]
辛伐他汀和依折麦布降低血清LDL胆固醇的程度依赖基线LDL胆固醇浓度而并非依赖基线值及胆固醇合成吸收参数的改变
Dieter Lütjohann,Frans Stellaard
Dieter Lütjohann
Objective: We questioned whether the baseline status of low-density lipoprotein cholesterol (LDL-C), cholesterol synthesis and absorption, and the changes in these parameters determine the change in serum LDL-C under stat...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2024 Jul;62(7):295-306. DOI:10.5414/CP204536 2024
Pegylated-interferon alpha (PEG-IFNα)-induced interstitial lung disease in a patient with chronic hepatitis B: A case report and literature review [0.03%]
聚乙二醇干扰素α诱导的慢性乙肝患者间质性肺病一例及文献复习
Minghui Shi,Shiyao Wang,Yanhong Ren et al.
Minghui Shi et al.
Objectives: Interferon (IFN)-induced lung injury is a rare but severe complication. Studies are needed to elucidate the demographic characteristics, clinical manifestations, and prognostic features of IFN-induced intersti...
Palatability evaluation of orally disintegrating tablets using a visual analog scale in clinical trials [0.03%]
视觉类比量表在临床试验中评价口服速崩片的口感接受度
Motoyasu Miura,Seiki Kojima,Shimako Tanaka et al.
Motoyasu Miura et al.
Objective: Visual analog scale (VAS) can be used to evaluate multiple parameters. There have been no reports on the verification of order effects or reproducibility of the VAS method for overall palatability of oral dosag...
Pharmacokinetics of apixaban in patients undergoing pancreaticoduodenectomy (PAP-UP) [0.03%]
胰十二指肠切除术患者的阿哌沙班药代动力学研究(PAP-UP)
Richard Zheng,Edwin Lam,Peter Altshuler et al.
Richard Zheng et al.
Objective: The impact of pancreaticoduodenectomy on absorption of drugs in the duodenum remains largely unknown. We aim to characterize the pharmacokinetics of apixaban in patients who had previously undergone pancreatico...
A cross-sectional study on the potential drug-drug interaction risk of COVID-19 patients in hospital [0.03%]
一项关于医院收治的新冠肺炎患者的潜在药物相互作用风险的横断面研究
Liu-Lyu Huang,Bo Jiang,Yong-Long Han et al.
Liu-Lyu Huang et al.
Objective: To investigate the incidence of and risk factors for potential drug-drug interactions (DDIs) among elderly patients with corona virus disease 2019 (-COVID-19) in hospital and to explore management strategies to...