Post-marketing safety concerns with montelukast: A pharmacovigilance study based on the FDA adverse event reporting system [0.03%]
蒙特鲁卡斯特上市后安全性问题的信号检测与关联分析：基于FDA不良事件数据库的药物警戒研究
Zhimin Ou,Ying Han,Wei Zhuang et al.
Zhimin Ou et al.
The United States Food and Drug Administration (FDA) has been warning about the psychiatric disorders associated with montelukast (MTK) for years. To study the characteristics of the presence of MTK-associated adverse events (AEs), we obtai...
Pharmacokinetic, bioequivalence, and safety assessments of two brands of 30-mg nifedipine controlled-release formulations in Chinese healthy subjects [0.03%]
两种30毫克硝苯地平控释制剂在中国健康受试者中的药代动力学、生物等效性和安全性评价
Huan Lu,Fei Zhou,Cuijie Rui et al.
Huan Lu et al.
Objective: This study aimed to analyze the pharmacokinetic (PK) characteristics, safety, and bioequivalence (BE) of a test (T) preparation of a nifedipine controlled-release tablet and the reference (R) drug (Adalat GTIS)...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2024 Oct;62(10):486-496. DOI:10.5414/CP204605 2024
Adequate IVIG dosing is associated with an improved long-term outcome in secondary immunodeficiency: A prospective, non-interventional study [0.03%]
IVIG充分剂量治疗与二次免疫缺陷长期改善相关性研究：一项前瞻性非干预性研究
Artur Bauhofer,Ümniye Balaban,Sonja Schimo et al.
Artur Bauhofer et al.
Objective: To assess the safety, tolerability, and effectiveness of the intravenous immunoglobulin (IVIG) Intratect 50 g/L in immunoglobulin replacement therapy (IgRT) in a prospective, large-scale non-interventional stud...
Rational use of short-term anorectic drugs for one-year effective treatment of obesity: An analysis of four studies [0.03%]
一年有效治疗肥胖的短期厌食药物的合理使用：四项研究分析
Cynthia Galicia-Quintanar,Héctor Isaac Rocha-González,María Elena Sánchez Mendoza et al.
Cynthia Galicia-Quintanar et al.
Background: Obesity is a complex disease for which pharmacotherapy is often used. Anti-obesity drugs (AODs) are characterized by inducing a variable inter-subject body weight reduction (BWR), the attainment of a plateau a...
A decision tree model for predicting high mono-N-desethylamiodarone concentrations and reducing tissue toxicity in patients with low-dose amiodarone therapy: A multicentral retrospective cohort study [0.03%]
用于预测低剂量胺碘酮治疗患者的高单胺-N-脱乙基胺碘酮浓度和减少组织毒性的决策树模型：多中心回顾性队列研究
Yuki Asai,Hiroki Arihara,Saki Omote et al.
Yuki Asai et al.
Objective: High plasma levels of mono-N-desethylamiodarone (MDEA), an active amiodarone metabolite, may be associated with tissue toxicity in heart failure (patients with heart rhythm disturbances); therefore, a tool that...
Chronic myeloid leukemia in an ulcerative colitis patient receiving azathioprine: A case report [0.03%]
一例使用硫唑嘌呤治疗溃疡性结肠炎患者的慢性髓系白血病病例报告
Asma Mensi,Nouha Trad,Raoudha Mansouri et al.
Asma Mensi et al.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease usually treated by azathioprine. It is a well-established risk factor for colorectal cancers and extraintestinal malignancies. Nevertheless, the risk of myeloid leukemia in pat...
A case study of impaired consciousness caused by alcohol consumption in a pediatric patient taking high-dose cefixime [0.03%]
一例高剂量服用头孢克肟致饮酒后意识障碍的儿科病例报告
Li Zheng,Gen Li,Liaoyun Zhang
Li Zheng
A variety of drugs have been known to induce disulfiram-like reactions in individuals exposed to ethanol, including certain cephalosporin antibiotics with methylthiotetrazole (MTT) substituents or methylthiodioxotriazine (MTDT) rings. Among...
Population pharmacokinetic study and application of ticagrelor and AR-C124910XX after percutaneous coronary intervention in Chinese patients with acute coronary syndrome [0.03%]
经皮冠状动脉介入术后急性冠脉综合征患者替格瑞洛及AR-C124910XX的群体药代动力学研究及其应用
Meng Liu,Jun Qin,XiaoQian Chu et al.
Meng Liu et al.
Objectives: This study aimed to understand the pharmacokinetics of ticagrelor in Chinese patients with acute coronary syndrome (ACS), identify influencing factors, and inform ticagrelor treatment optimization. ...
Evidence-based clinical pharmacology using network analysis of the curcuma-containing traditional Chinese medication Changpu-Yujin: Efficacy in the treatment of insomnia [0.03%]
基于网络药理学的含姜黄药物菖蒲郁金治疗失眠的有效性研究
Jianran Ma,Qian Hu,Qing Hu et al.
Jianran Ma et al.
Membrane P-glycoprotein expression in lymphocytes from adult patients with refractory glomerulonephritis [0.03%]
成人难治性肾小球肾炎外周血淋巴细胞膜P-糖蛋白的表达研究
Shanshan Jin,Xinrong Zou,Xue Xue et al.
Shanshan Jin et al.
Objectives: To investigate the expression of P-glycoprotein in T-cell subpopulations of lymphocytes from adult patients with refractory glomerulonephritis (GN). ...