Mechanism of cytotoxicity of paraquat. I. NADH oxidation and paraquat radical formation via complex I [0.03%]
百草枯细胞毒性的机制(I). 复合物I介导的NADH氧化和百草枯自由基生成作用
T Fukushima,K Yamada,A Isobe et al.
T Fukushima et al.
The mechanism of cytotoxicity by paraquat was studied focusing attention on its effect on the mitochondrial electron transport system. Paraquat inhibited both mitochondrial and cytoplasmic malate dehydrogenase activities. NADH oxidation was...
A comparative study of the effect of atrial natriuretic peptide (ANP) on the secretory activity of rat adrenal cortex and angiotensin-II-responsive adrenocortical autotransplants [0.03%]
心房利钠肽对大鼠肾上腺皮质及血管紧张素Ⅱ依赖性自体移植皮质分泌活动影响的比较研究
A S Belloni,G Neri,P G Andreis et al.
A S Belloni et al.
Rat adrenocortical autotransplants regenerated from capsular-tissue fragments implanted in the musculus gracilis displayed an in-vitro basal gluco- and mineralocorticoid secretion qualitatively similar to that of adrenal quarters from contr...
Effect of exogenous antioxidant enzymes and antioxidants on the development of endotoxin-induced hepatocellular necrosis in rats [0.03%]
外源性抗氧化酶及抗氧化剂对内毒素致大鼠肝细胞坏死的影响
Y Shibayama,K Nakata
Y Shibayama
To determine whether released oxidants in endotoxemia contribute to the development of hepatocellular necrosis, we examined the effects of antioxidants and antioxidant enzymes on endotoxin hepatotoxicity in rats. In rats given endotoxin, fo...
Study of morphological manifestations of pulmonary arteries in experimental pulmonary hypertension provoked by administration of long-term, low-dose Na2EDTA--especially in aneurysmal changes and plexiform-like lesions [0.03%]
长期低剂量Na2EDTA诱发实验性肺动脉高压的血管形态学研究--特别着重于动脉瘤样改变和类似plexiform病变的研究
H Yamaguchi,H Kaku,M Morisada
H Yamaguchi
In a previous paper (Yamaguchi et al. 1991) we informed that the administration of 1 ml. of 6% Na2EDTA every day intraperitoneally for two months led to the death of the guinea pigs, and autopsy revealed that the causes of death were right ...
Suppressive effect of estrogen on hepatocellular tumorigenesis induced in mice by 3'-methyl-4-dimethylaminoazobenzene [0.03%]
雌激素抑制3'-甲基-4-二甲氨基偶氮苯所致小鼠肝细胞肿瘤发生的作用机制研究
R Yamamoto,H Iishi,M Tatsuta et al.
R Yamamoto et al.
Treatment of female C57BL/6 x DS-F1 mice with 3'-methyl-4- dimethylaminoazobenzene (3'-Me-DAB) neonatally resulted in the development of hepatocellular adenomatous nodules. Ovariectomy at 1 month of age greatly hastened the time of appearan...
In vitro induction of type II pneumocyte-related differentiation in a clonal fetal bronchiolo-alveolar epithelial cell line (M3E3/C3) [0.03%]
体外诱导肺泡上皮细胞系(M3E3/C3)向II型肺泡细胞分化的研究
P G Germann,S Ueberschär,A Gerull et al.
P G Germann et al.
The aim of the present study is to investigate the differentiation of a cloned fetal Syrian hamster lung epithelial cell line, M3E3/C3, to assume morphological and biochemical features of Type II pneumocytes (phospholipid synthesis). The us...
Postnatal development of sex differences in renal tubular transport of p-aminohippurate (PAH) in rats [0.03%]
大鼠肾小管分泌对氨基马尿酸(PAH)的性别差异的产后发育
H Bräunlich,T Meinig,U Grosch
H Bräunlich
Compared with female rats a distinctly higher rate of accumulation of p-aminohippurate (PAH) in renal cortical slices from mature male rats can be proved; there are no sex differences in young rats with immature kidney function. Postnatal d...
Vasodilating effect of dipyridamole on rat endoneurial vessels: morphometric study [0.03%]
二磷酸盐对大鼠内神经血管的血管舒张作用：形态计量学研究
S J Connor,H Nukada
S J Connor
Ischaemia plays an important role in the pathogenetic mechanism of various neuropathies. To study the possible vasodilating effects of dipyridamole on peripheral nerve vessels, morphometric analysis of endoneurial vessels was undertaken in ...
G A Balint
G A Balint
Ricin (RIC) the toxic protein of castor oil seeds (Ricinus communis, Euphorbiaceae;) given intraperitoneally in sublethal doses causes fever in a dose-dependent manner in the following mammals: rabbit, cat, guinea pig, rat and vervet monkey...
Reduction of thyroxine-induced necrotic foci and thrombi in the mouse liver by androgen, oestrogen and glucocorticoid but not by progesterone [0.03%]
雄激素、雌激素和糖皮质激素但不是孕酮减少甲状腺素引起的肝细胞死亡病灶和血栓形成
R Yamamoto,M Oda,T Yamamoto et al.
R Yamamoto et al.
Injections of thyroxine (T4) at a dose of 10 micrograms/mouse/day into castrated adult female or male C57BL/6 mice for 3 weeks induced multiple necrotic foci and portal thrombi in the liver at high incidences. However, injections of T4 into...