Tissue zinc levels in precancerous tissue in the gastrointestinal tract of azoxymethane (AOM)-treated rats [0.03%]
偶氮甲烷(AOM)诱导的大鼠胃肠道癌前病变组织中的锌水平
Pamela Christudoss,R Selvakumar,Anna B Pulimood et al.
Pamela Christudoss et al.
Alterations in tissue zinc levels have been documented in patients with gastrointestinal tract malignancies and more frequently, in those with colonic cancer. However, the precise role of tissue zinc in carcinogenesis is not well elucidated...
Increased glutathione levels and activity of PON1 (phenyl acetate esterase) in the liver of rats after a single dose of cyclophosphamide: a defense mechanism? [0.03%]
环磷酰胺单次给药后大鼠肝脏中谷胱甘肽水平和PON1（苯乙酸酯酶）活性升高：一种防御机制吗？
Premila Abraham,Emila Sugumar
Premila Abraham
The clinical utility of cyclophosphamide (CYP) as an anticancer drug is limited by its urotoxicity and nephrotoxicity and to a lesser extent by its hepatotoxicity. The present study was undertaken in order to find out the reason why liver i...
Jochen Woicke,Stephen K Durham,Mark G Mense
Jochen Woicke
Nucleoside analogues are used in the treatment of viral infections, including those caused by human immunodeficiency virus, cytomegalovirus, and herpes virus. These drugs are beneficial in the treatment of human disease, but are associated ...
Diazinon toxicity affects histophysiological and biochemical parameters in rabbits [0.03%]
毒辛毒性对兔生理生化参数的影响
Mona A H Yehia,Sabah G El-Banna,Aly B Okab
Mona A H Yehia
Diazinon is a widely used pesticide in agriculture. So, the current work aimed to investigate the effects of diazinon exposure on some physiological and biochemical parameters, as well as, histopathological changes and histochemical acetyl-...
Makoto Sato,Keisuke Kitaura,Takanori Minami et al.
Makoto Sato et al.
Local cooling of the testis was reported to cause testicular abnormality, but there is no information regarding the effect of whole body cooling, such as hypothermia on spermatogenesis. We investigated whether hypothermia would cause testic...
Nicotine-induced prenatal overexposure to maternal glucocorticoid and intrauterine growth retardation in rat [0.03%]
尼古丁致大鼠胎盘过度暴露于母体糖皮质激素和宫内生长迟缓
Man Chen,Ting Wang,Zhang-Xiu Liao et al.
Man Chen et al.
Overexposure to glucocorticoid during fetal development can result in intrauterine growth retardation (IUGR) as well as other diseases after birth. The purpose of this study is to investigate the possibility of glucocorticoid disturbance-me...
Inhibitory effect of ketamine on phosphorylation of the extracellular signal-regulated kinase 1/2 following brain ischemia and reperfusion in rats with hyperglycemia [0.03%]
氯化钾对高糖大鼠脑缺血再灌注后ERK磷酸化的影响
Jian-Zhong Zhang,Li Jing,Feng-Ying Guo et al.
Jian-Zhong Zhang et al.
To determine if the inhibitory effects of ketamine on the extracellular signal-regulated kinase (ERK) 1/2 are involved in reduction of the hyperglycemia-exaggerated cerebral ischemic lesion, rats with normoglycemia, hyperglycemia, or hyperg...
Spontaneous neoplasms observed in cynomolgus monkeys (Macaca fascicularis) during a 15-year period [0.03%]
15年间在食蟹猴中观察到的自发性肿瘤
J Kaspareit,S Friderichs-Gromoll,E Buse et al.
J Kaspareit et al.
A total of 33 tumors were observed during a time period of 15 years (1992-2006) in cynomolgus monkeys. The great majority of neoplasms was benign (23 benign neoplasms versus 10 malignant tumors). Fourteen appeared in males and 19 in females...
Dimethoate-induced biochemical and histopathological changes in the liver of rats [0.03%]
二甲硫磷致大鼠肝组织生化及病理改变
Ferah Sayim
Ferah Sayim
Dimethoate is an organophosphorus insecticide and acaricide used for the control of a wide range of insects, including houseflies and mites, on a variety of fruits, vegetables, field and forestry crops. The aim of the current study was to e...
Regenerative capacity differs between micro- and macrovesicular hepatic steatosis [0.03%]
微泡状和大泡状肝脂肪变再生能力不同
Agnieszka Oleszczuk,Michael Spannbauer,Andrea Tannapfel et al.
Agnieszka Oleszczuk et al.
Introduction: Independent of etiology, the hepatic microvesicular steatosis has a worse prognosis compared with macrovesicular steatosis. Proliferation compensates for apoptosis and reflects regenerative mechanisms follow...