Cyclic strain induces FosB and initiates osteogenic differentiation of mesenchymal cells [0.03%]
周期性拉伸应变可诱导成纤维细胞生长因子并启动间充质细胞的成骨分化
Carl Haasper,Michael Jagodzinski,Maren Drescher et al.
Carl Haasper et al.
Mechanical loading is crucial for bone remodeling and osteoblast differentiation. FosB belongs to the AP-1 family of transcription factors, a group of proteins known to regulate osteoblast differentiation and bone formation. In mice, FosB i...
Apoptotic effect of organophosphorus insecticide chlorpyrifos on mouse retina in vivo via oxidative stress and protection of combination of vitamins C and E [0.03%]
氧磷类杀虫剂氯毗硫磷对小鼠视网膜细胞凋亡作用的体内实验及维C、维E对其联合保护效应的研究
Fu Yu,Ziren Wang,Bao Ju et al.
Fu Yu et al.
Organophosphorus insecticide poisoning is widely investigated, and a growing number of evidence indicates its effects to cause ocular lesions, but the mechanisms of its ocular effects are not well elucidated. Here, effects of organophosphor...
Cerebral vacuolation induced in rats by the administration of LUP-3FDC, an anti-tuberculosis cocktail [0.03%]
LUP-3FDC（抗结核药组合）引起的脑室管腔扩大病变的实验研究
Monique Y Wells,Georg J Krinke
Monique Y Wells
A study was conducted to determine the subacute oral toxicity of LUP-3FDC (a cocktail composed of rifampicin, isoniazid and pyrazinamide) and LUP-Q1 (gatifloxicin sesquihydrate) as well as the potential effects of their combination when adm...
Differentially expressed pro- and anti-apoptogenic genes in response to benzene exposure: Immunohistochemical localization of p53, Bag, Bad, Bax, Bcl-2, and Bcl-w in lung epithelia [0.03%]
苯致差异表达的促和抗细胞凋亡基因及其在肺上皮中p53、Bag、Bad、Bax、Bcl-2及Bcl-w蛋白免疫组化定位研究
Cyprian V Weaver,Shi-Ping Liu
Cyprian V Weaver
Benzene, a well-known human carcinogen, is a commonly used industrial chemical that evokes further toxicological concern because of its potential genotoxic risks as a constituent of petrol and the byproduct of combustion and cigarette smoke...
Acetaminophen-induced liver damage in mice: effects of some medicinal plants on the oxidative defense system [0.03%]
对乙酰氨基酚致小鼠肝损伤：某些药用植物对氧化防御系统的影响
M Tolulope Olaleye,B T João Rocha
M Tolulope Olaleye
Paracetamol (acetaminophen, PCM) is widely used as an over-the-counter analgesic and antipyretic drug. Intake of a large dose of PCM may result in severe hepatic necrosis. Oxidative stress mediated by oxidative capacities of the PCM metabol...
Elke Hartmann,Volker Strauss,Rolf Eiben et al.
Elke Hartmann et al.
The revision of the OECD TG 407 test guideline (repeated dose 28-day oral toxicity study in rodents) focuses on endpoints to detect endocrine activities of chemicals. The new endpoints are likely to influence other previously established co...
Reactive and proliferative changes of splenic reticulum cells of rats investigated with special staining methods and immunohistochemistry [0.03%]
特染法和免疫组化法对大鼠脾红髓网状细胞反应性和增殖性变化的研究
Christine Ruehl-Fehlert,Elke Hartmann,Matthias Rinke
Christine Ruehl-Fehlert
In the rat spleen, reactive and proliferative changes of the reticulum cells are rare events and seem to occur almost exclusively in the red pulp. The normal structure of the splenic reticulum cell and fiber lattice and examples of spontane...
Postoperative fibromatosis-type fibromas in the Bhd gene mutant (Nihon) rat [0.03%]
BHD基因突变(nihon)大鼠的术后纤维瘤样纤维瘤病
Mami Kouchi,Kazuo Okimoto,Izumi Matsumoto et al.
Mami Kouchi et al.
Fibromatosis-type fibromas were found to develop at abdominal surgical sites in 4 heterozygous Nihon rats, a model for the human Birt-Hogg-Dubé syndrome. In all 4 rats, solitary and firm nodules were located within the lateral abdominal mu...
Growth-related changes of parameters of the methylation cycle and jejunal aminopeptidase M in the rat [0.03%]
大鼠生长相关甲基循环参数及空肠氨基肽酶M的变化规律
Jens Weingärtner,Sergej Maile,Jochen Fanghänel et al.
Jens Weingärtner et al.
During development from juvenility to adulthood, rats displayed constant vitamin B12, decreasing folic acid and increasing homocysteine levels in blood plasma parallel to decreasing aminopeptidase M activities in the jejunum. The rising hom...
Accumulation of cadmium and its effects on testis function in rats given diet containing cadmium-polluted radish bulb [0.03%]
镉的蓄积及其对受污染萝卜块根喂养大鼠睾丸功能的影响
Samir Haouem,Mohamed Fathel Najjar,Abdelhamid El Hani et al.
Samir Haouem et al.
The aim of this study was to examine the accumulation of cadmium (Cd) incorporated in radish bulb and its effects on testes function in male rats. Control animals were given diet containing ordinary radish bulb for 4, 8 and 12 weeks, while ...