Ameliorative prospective of alpha-mangostin, a xanthone derivative from Garcinia mangostana against beta-adrenergic cathecolamine-induced myocardial toxicity and anomalous cardiac TNF-alpha and COX-2 expressions in rats [0.03%]
伽古树来源的提取物α-紫檀茋对肾上腺素致大鼠心肌毒性的保护作用及对心脏TNF-α和COX-2表达的影响研究
Pandima Devi Sampath,Kannan Vijayaragavan
Pandima Devi Sampath
Altered membrane integrity and inflammation play a key role in cardiovascular damage. We investigated the salubrious effect of exogenously administered alpha-mangostin against beta-adrenergic cathecolamine-induced cardiovascular toxicity wi...
Gerhard Heinemeyer
Gerhard Heinemeyer
Risk assessment of health hazards introduced by chemicals is based on two basic elements: (i) exposure assessment and (ii) hazard identification. Risk characterisation is performed by comparing the exposure level with the NOAEL to establish...
Global recognition of qualified toxicologic pathologists: where we are now and where we need to go [0.03%]
合格毒理病理学家的全球认可：现状与未来方向
Robert A Ettlin,Brad Bolon,Ian Pyrah et al.
Robert A Ettlin et al.
While there are a few national schemes for accreditation/certification of toxicologic pathologists (e.g. in Japan and UK), a global recognition system for bench toxicologic pathologists is missing, as are universal standards defining their ...
Antioxidant effects of methionine, alpha-lipoic acid, N-acetylcysteine and homocysteine on lead-induced oxidative stress to erythrocytes in rats [0.03%]
甲硫氨酸、α-硫辛酸、N-乙酰半胱氨酸和同型半胱氨酸对铅所致大鼠红细胞氧化损伤的抗氧化作用研究
Emrah Caylak,Metin Aytekin,Ihsan Halifeoglu
Emrah Caylak
Lead, widely used in industry, is a great environmental health problem. Many studies have examined its effects on the health of both humans and animals. Experimental studies have shown that sulphur-containing antioxidants have beneficial ef...
Tetracycline-induced reproductive toxicity in male rats: effects of vitamin C and N-acetylcysteine [0.03%]
维生素C和N-乙酰半胱氨酸对四环素致雄性大鼠生殖毒性的干预作用
Ebenezer O Farombi,Mercy C Ugwuezunmba,Teclar T Ezenwadu et al.
Ebenezer O Farombi et al.
Tetracycline, a broad-spectrum antibiotic employed clinically in the treatment of bacteria infections, is known to cause a number of biochemical dysfunctions and suspected to induce testicular damage to animals and humans, but there is pauc...
Statistical analysis of in vitro data for risk assessment - exemplified for a case of Ames test data [0.03%]
体外数据的统计分析在风险评估中的应用-以Ames试验为例
Markus Roller,Michaela Aufderheide
Markus Roller
Ames test data of experiments with smoke of six cigarette types were used for dose-response analysis and for derivation of a measure of mutagenic potency. Each cigarette type had been tested using a smoking machine and four dilutions of the...
Foreword: Congress on Alternative Test Methods in Inhalation Toxicology [0.03%]
序言：“吸入毒理学替代检测方法大会”报告摘要集
Richard Vogel
Richard Vogel
How do we compare dose to cells in vitro with dose to live animals and humans? Some experiences with inhaled substances [0.03%]
体外细胞剂量与活体动物和人体剂量的比较方法——吸入毒物的一些经验总结
Per Gerde
Per Gerde
The inhalation route provides closer contact between the ambient environment and living cells than the other major routes-of-entry to the body. In addition, the ambient air transporting exogenous agents to the close proximity of living cell...
Evidence of gastro-intestinal system as an active and toxic target of sasanqua saponins extract [0.03%]
枫荷苷导致小鼠急性中毒的靶器官证据及机制研究
Jia Shen,Cunai Cao,Hui Su et al.
Jia Shen et al.
Sasanqua saponins extract (SSE) was prepared from the remainder of seeds of Camellia sasanqua after oil extract using ethanol as solvent. We have now evaluated the acute and subchronic toxicity of SSE by oral route in mice. A single oral ad...
Retinal electrophysiology for toxicology studies: applications and limits of ERG in animals and ex vivo recordings [0.03%]
用于毒理学研究的视网膜电生理：动物和体外记录中ERG的应用与局限性
Serge Georges Rosolen,Bogdan Kolomiets,Oscar Varela et al.
Serge Georges Rosolen et al.
Assessing retinal drug toxicity is becoming increasingly important as different molecules are now developed for the treatment of neurodegenerative diseases and vascular disorders. In pharmacology and toxicology, the electroretinogram (ERG) ...