Complex issues with examining diesel exhaust toxicity: is the task getting easier or harder? [0.03%]
检验柴油尾气毒性的复杂问题：任务是变得容易还是困难了？
Michael C Madden
Michael C Madden
Petroleum diesel exhaust (DE) exposure has been linked to several health effects including lung cancer. The role of DE in the cardiopulmonary effects associated with particulate matter (PM) exposures is unclear; this uncertainty drives curr...
Comparison of primary lung tumor incidences in the rat evaluated by the standard microscopy method and by multiple step sections [0.03%]
大鼠肺肿瘤发生率的比较研究——常规显微镜检查法与多层面切片观察法结果的比较
Angelika Kolling,Heinrich Ernst,Susanne Rittinghausen et al.
Angelika Kolling et al.
The data presented in this paper have been derived from a carcinogenicity experiment with rats as part of a comprehensive research project focused on experimental studies on the toxicity and carcinogenicity of intratracheally instilled gran...
Inhalation toxicity studies: OECD guidelines in relation to REACH and scientific developments [0.03%]
吸入毒性研究：经合组织指南与欧盟《化学品注册、评估、授权和限制制度》及科学进展的关系
Josje H E Arts,H Muijser,D Jonker et al.
Josje H E Arts et al.
The OECD Health Effects Test Guidelines (TGs) provide guidance concerning the use of methods for the identification and characterization of hazards from chemical substances. These TGs are largely based on tests in routine use for many years...
Successful validation of in vitro methods in toxicology by ZEBET, the National Centre for Alternatives in Germany at the BfR (Federal Institute for Risk Assessment) [0.03%]
德国BfR（风险评估联邦研究所）下属的ZEBET（替代方法国家中心）对体外毒性试验方法的有效验证
Horst Spielmann,Barbara Grune,Manfred Liebsch et al.
Horst Spielmann et al.
A short description of the history of the 3Rs concept is given, which was developed as the scientific concept to refine, reduce and replace animal experiments by Russel and Burch more than 40 years ago. In addition, the legal framework in E...
Administration of ciprofibrate to lactating mothers induces PPARalpha-signaling pathway in the liver and kidney of suckling rats [0.03%]
塞来昔布对泌乳大鼠的药代动力学及其向乳儿大鼠转运的研究
Marco Fidaleo,Claudia Sartori
Marco Fidaleo
It is well known that the hypolipidemic drug ciprofibrate induces peroxisome proliferation in rodent liver, which in turn leads to the oxidative stress, and modifies some parameters related to cell proliferation and apoptosis. The administr...
Glomerular basement membrane alterations induced by gentamicin administration in rats [0.03%]
庆大霉素致大鼠肾小球基底膜改变
Nenad Stojiljkovic,Dragan Mihailovic,Slavimir Veljkovic et al.
Nenad Stojiljkovic et al.
The widespread therapeutic use of the aminoglycoside antibiotic gentamicin (GM) is limited by its nephrotoxic side effect, which can lead to acute renal failure. This study aimed at examining effects of high, supratherapeutic doses of genta...
Baroreflex sensitivity and oxidative stress in the LDL receptor knockout mice [0.03%]
低密度脂蛋白受体基因敲除小鼠的血压感受性反射敏感性和氧化应激反应的关系研究
Cristina Campos,Mariane Bertagnolli,Juliano Evangelho et al.
Cristina Campos et al.
This study aims at observing the effect of low-density lipoprotein (LDL) receptor deficiency in cholesterol blood levels, baroreflex sensitivity (BRS), nitric oxide (NO) bioavailability, and oxidative stress. The lack of LDL receptors in mi...
Tomato oleoresin inhibits DNA damage but not diethylnitrosamine-induced rat hepatocarcinogenesis [0.03%]
番茄红素抑制DNA损伤但不能抑制二乙基亚硝胺所致大鼠肝癌发生
Clarissa Scolastici,Gisele A D Lopes,Luís F Barbisan et al.
Clarissa Scolastici et al.
Various studies have shown that lycopene, a non-provitamin A carotenoid, exerts antioxidant, antimutagenic and anticarcinogenic activities in different in vitro and in vivo systems. However, the results concerning its chemopreventive potent...
Rho-kinase and contractile apparatus proteins in murine airway hyperresponsiveness [0.03%]
小鼠气道高反应性中Rho激酶与收缩装置蛋白的关系
Martin Witzenrath,Birgit Ahrens,Bernd Schmeck et al.
Martin Witzenrath et al.
Airway hyperresponsiveness (AHR) is a hallmark of bronchial asthma. Increased expression of smooth muscle contractile proteins or increased responsiveness of the contractile apparatus due to RhoA/Rho-kinase activation may contribute to AHR....
Cytotoxicity of the beta-carboline alkaloids harmine and harmaline in human cell assays in vitro [0.03%]
harmine和harmaline的β-咔啉生物碱的细胞毒作用
Judith Jiménez,Leticia Riverón-Negrete,Fikrat Abdullaev et al.
Judith Jiménez et al.
beta-Carboline alkaloids are natural products widely distributed in plants and also found in alcoholic beverages, well-cooked foods and tobacco smoke. Various authors have reported genotoxic activities of several carboline in prokaryotic an...