Alternative test methods in inhalation toxicology: challenges and opportunities [0.03%]
吸入毒理学中替代测试方法的挑战与机遇
Daniel L Costa
Daniel L Costa
Requirements under the new European Union rules regarding Registration, Evaluation & Authorization of Chemicals (REACH) necessitate widespread toxicological safety testing of existing and new chemicals. Given the enormity of new and already...
Transplacental exposure to the vacuolar-ATPase inhibitor bafilomycin disrupts survival signaling in beta cells and delays neonatal remodeling of the endocrine pancreas [0.03%]
血管杆蛋白ATP酶抑制剂巴非洛米森的胎盘转运干扰胰岛素分泌细胞的生存信号并延迟内分泌胰腺的重塑反应
Kalindi D Hettiarachchi,Paul Z Zimmet,Nika N Danial et al.
Kalindi D Hettiarachchi et al.
A wave of beta cell apoptosis occurs around 2 weeks of age in rats and mice. We have previously reported that exposure in utero to bafilomycin, a plecomacrolide antibiotic that inhibits the vacuolar (v)ATPase enzyme and contaminates the hum...
Emmanuelle Balme,Daniel Robert Roth,Elias Perentes
Emmanuelle Balme
Spontaneous meningiomas are extremely rare tumors in small laboratory animals, except in some strains of rats and in the B6C3F1 mouse. We report the case of a male CD-1 mouse in poor health condition, with severe apathy and partial paresis ...
Anja Thielen,Hubert Klus,Lutz Müller
Anja Thielen
Cigarettes are a modern and industrial form of tobacco use and obviously involve more than just tobacco. A multitude of physical processes and chemical reactions occur inside the burning zone of a cigarette. Cigarette smoke is an aerosol of...
Creation of a digital slide and tissue microarray resource from a multi-institutional predictive toxicology study in the rat: an initial report from the PredTox group [0.03%]
来自多机构预测毒理学研究的数字切片和组织微阵列资源的大鼠数据构建：PredTox小组初步报告
Laoighse Mulrane,Elton Rexhepaj,Valerie Smart et al.
Laoighse Mulrane et al.
The widespread use of digital slides has only recently come to the fore with the development of high-throughput scanners and high performance viewing software. This development, along with the optimisation of compression standards and image...
An efficient approach to study the toxicological effects of complex mixtures [0.03%]
一种研究复杂混合物毒理效应的有效方法
Michaela Aufderheide
Michaela Aufderheide
In vitro studies in the field of inhalation toxicology suffer a number of problems due to the difficulties in exposing cells of the respiratory tract directly to inhalable substances in a way that is comparable to the in vivo situation. The...
Prevalidation of in vitro continuous flow exposure systems as alternatives to in vivo inhalation safety evaluation experimentations: outcome from MAAPHRI-PCRD5 research program [0.03%]
体外连续流暴露系统预验证作为体内吸入安全评价实验的替代方法：MAAPHRI-PCRD5研究项目的成果
Jean-Paul Morin,Virginie Hasson,Mamadou Fall et al.
Jean-Paul Morin et al.
Diesel engine emission aerosol-induced toxicity patterns were compared using both in vitro (organotypic cultures of lung tissue) and in vivo experimentations mimicking the inhalation situation with continuous aerosol flow exposure designs. ...
Jürgen Pauluhn
Jürgen Pauluhn
Highly standardized and controlled inhalation studies are required for hazard identification to make test results reproducible and comparable and also to fulfill general regulatory requirements for the registration of new drugs, pesticides,...
Anne-Laure Bauchet,Laëtitia Elies,Pierre Maliver et al.
Anne-Laure Bauchet et al.
Mammary gland adenomyoepitheliomas are benign complex mammary gland tumors composed of neoplastic cells of epithelial and myoepithelial origins, described in many species (humans, dogs, cats, rats) and rarely in mice. We report here an aden...