Pathophysiological effects of Androctonus australis hector scorpion venom: tissue damages and inflammatory response [0.03%]
Androctonus australis Hector蝎子毒液的病理生理效应：组织损伤和炎症反应
Sonia Adi-Bessalem,Djelila Hammoudi-Triki,Fatima Laraba-Djebari
Sonia Adi-Bessalem
In this study, the effects of sublethal dose of Androctonus australis hector (Aah) venom on the enzymatic activities (creatine phospho-kinase and lactate dehydrogenase) and histopathological changes of heart and lungs' organs were determine...
In vitro models for the assessment of inflammatory and immuno-modulatory effects of the volatile organic compound chlorobenzene [0.03%]
氯苯等挥发性有机化合物的体外炎症和免疫评估模型
Irina Lehmann,Carmen Röder-Stolinski,Karen Nieber et al.
Irina Lehmann et al.
An in vitro cell culture system based on an air/liquid culture technique was developed which allows a direct exposure of cells to volatile chemicals without medium coverage. For the establishment of the experimental system, chlorobenzene wa...
Mast cell inhibition by ketotifen reduces splanchnic inflammatory response in a portal hypertension model in rats [0.03%]
酮替芬通过抑制肥大细胞减少肝硬化门静脉高压模型中内脏炎症反应
Fernando Sánchez-Patán,Maria-Angeles Aller,Carmen Cuellar et al.
Fernando Sánchez-Patán et al.
Experimental early prehepatic portal hypertension induces an inflammatory exudative response, including an increased infiltration of the intestinal mucosa and the mesenteric lymph nodes by mast cells and a dilation and tortuosity of the bra...
Altug Yavasoglu,M Ali Karaaslan,Yigit Uyanikgil et al.
Altug Yavasoglu et al.
Anatoxin-a, a potent neurotoxin, is one of a number of toxins produced by cyanobacteria especially some strains of Anabaena. Toxic cyanobacteria are found worldwide in inland and coastal water environments. The present study was performed t...
Cardioprotective activity of Ginkgo biloba Phytosomes in isoproterenol-induced myocardial necrosis in rats: a biochemical and histoarchitectural evaluation [0.03%]
银杏叶植物体对异丙肾上腺素诱导的大鼠心肌坏死的保护作用：生化和组织学评估
Vandana S Panda,Suresh R Naik
Vandana S Panda
The protective effects of Ginkgo biloba Phytosomes (GBP) in isoproterenol (ISO)-induced cardiotoxicity and the antioxidant activity involved in this protection were investigated in rats. Myocardial infarction was produced in rats with 65, 8...
Histological alterations in ovaries of pubertal female rats induced by triphenyltin [0.03%]
三苯基锡对青春期大鼠卵巢的组织学影响研究
B Watermann,K Grote,K Gnass et al.
B Watermann et al.
Triphenyltin is an organotin compound that has been used extensively as an antifouling biocide and as an agricultural pesticide. Certain organotin compounds act as endocrine-active agents and have been reported to affect reproduction in mol...
Predictivity of animal studies for human injection site reactions with parenteral drug products [0.03%]
动物模型预测人用注射剂型药品注射部位反应的有效性
Jeffery A Engelhardt
Jeffery A Engelhardt
The value and predictive power of nonclinical studies for potential effects of investigational medicinal products in humans is often debated. The subject of general predictivity of animal toxicity studies has been addressed on several occas...
5-hydroxytryptamine (5HT)-induced valvulopathy: compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats [0.03%]
5-羟色胺（5-HT）诱导的瓣膜病：Sprague Dawley大鼠瓣膜组成型改变与5-HT2B受体和5-HT转运蛋白转录本变化相关性研究
Chandikumar S Elangbam,Lauren E Job,Leah M Zadrozny et al.
Chandikumar S Elangbam et al.
Several drugs have been linked to valvulopathy in humans, including therapeutic agents for obesity, Parkinson's disease and migraine. There is increasing evidence that the 5-hydroxytryptamine 2B receptor (5HT2BR) activation and/or increased...
Andreas Hensel
Andreas Hensel
Alteration of fertility endpoints in adult male F-344 rats by subchronic exposure to inhaled benzo(a)pyrene [0.03%]
成年雄性F-344大鼠吸入苯并(a)芘的亚慢性暴露对其生殖终点的影响
Aramandla Ramesh,Frank Inyang,Donald D Lunstra et al.
Aramandla Ramesh et al.
The objective of this study was to evaluate the reproductive risk associated with exposure of adult male Fisher-344 rats to inhaled benzo(a)pyrene (BaP). Rats were assigned randomly to a treatment or control group. Treatment consisted of su...