Soyasaponins inhibit the proliferation of Hela cells by inducing apoptosis [0.03%]
大豆皂苷通过诱导凋亡抑制HeLa细胞增殖
Jun-Xia Xiao,Guo-Qing Huang,Sheng-Hua Zhang
Jun-Xia Xiao
This research aimed at investigating the effect of soyasaponins on the proliferation of Hela cells. SS-II, the second fraction of soyasaponins, was separated by column chromatographic method with D101A macroporous resin from soybeans. SS-II...
Acute liver toxicity by carbon tetrachloride in HSP70 knock out mice [0.03%]
碳氯化合物所致敲除HSP70小鼠急性肝损伤模型的建立
Ji-Ye Song,Lan Li,Jae-Bum Ahn et al.
Ji-Ye Song et al.
The effects of carbon tetrachloride (CCl(4)) treatment on acute liver damage in knock out (heat shock proteins -- HSP70-/-) mice and wild-type (C57BL/6) mice were examined. Acute liver injury was induced by a single intraperitoneal injectio...
Accumulation of cadmium and its effects on liver and kidney functions in rats given diet containing cadmium-polluted radish bulb [0.03%]
受镉污染萝卜对大鼠肝肾功能影响及体内镉蓄积动力学研究
Samir Haouem,Najla Hmad,Mohamed Fathel Najjar et al.
Samir Haouem et al.
The aim of this study was to examine the accumulation of cadmium (Cd) incorporated in radish bulb and its effects on liver and kidney functions in male rats. Control animals were given diet containing ordinary radish bulb for 4, 8 and 12 we...
Differences between the data bases, statistical analyses, and interpretations of lung tumors of the 19-dust study: two controversial views [0.03%]
关于19例尘肺队列肺癌的数据库、统计分析及结果解读之异同——两种对立的观点
Markus Roller
Markus Roller
The article presents a comparison of two opposing evaluations and interpretations of the carcinogenicity study with 19 granular dusts. It is one of the two responses to a Letter to the Editor of Exp Toxicol Pathol by Morfeld and Borm(1), wh...
Re: pulmonary tumor types induced in Wistar rats of the so-called "19-dust study" [0.03%]
关于所谓“19尘研究”的Wistar大鼠肺肿瘤类型诱导研究报告
Peter Morfeld,Paul Borm
Peter Morfeld
A modified Ames assay reveals the mutagenicity of native cigarette mainstream smoke and its gas vapour phase [0.03%]
改良的艾姆斯试验揭示了卷烟主流烟气及其气体蒸汽相的致突变性
Michaela Aufderheide,Helga Gressmann
Michaela Aufderheide
The evaluation of the mutagenic activity of cigarette smoke is mostly based on studies with condensates or extracts in the standard Ames assay. These samples only insufficiently reflect the composition of the actual generated aerosol. There...
Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in rat and murine models of lung inflammation [0.03%]
单克隆抗体在大鼠和小鼠肺部炎症模型中用于评估过敏毒素受体的表达情况
Thomas Tschernig,Ziba Kiafard,Christian Dibbert et al.
Thomas Tschernig et al.
The anaphylatoxins C3a and C5a are involved in the pathophysiology of microbial as well as allergic inflammation in the lungs. Besides their expression in leukocytes, receptors for C3a and C5a (C3aR and C5aR) have been noted in alveolar and...
Methionine-supplemented diet augments hepatotoxicity and prooxidant status in chronically ethanol-treated rats [0.03%]
甲硫氨酸补充饮食可增强慢性乙醇处理的大鼠的肝毒性及促氧化状态
Seda Yalçinkaya,Yeşim Unlüçerçi,Müjdat Uysal
Seda Yalçinkaya
The purpose of this study was to investigate whether high methionine (HM) diet may influence the development of ethanol-induced hepatotoxicity and prooxidant-antioxidant balance in the liver. Rats received drinking water containing ethanol ...
Pfaffia paniculata (Brazilian ginseng) methanolic extract reduces angiogenesis in mice [0.03%]
Pfaffia paniculata(巴西人参)甲醇萃取物可减少小鼠血管生成现象
Carolina Scarpa Carneiro,Frederico Azevedo Costa-Pinto,Ana Paula da Silva et al.
Carolina Scarpa Carneiro et al.
Pfaffia paniculata (Brazilian ginseng) roots have been indicated for the treatment of several diseases. Our studies have shown that P. paniculata roots present antineoplastic effects and cancer chemopreventive activity in a mouse hepatocarc...
Cell proliferation measurement in cecum and colon of rats using scanned images and fully automated image analysis: validation of method [0.03%]
大鼠结肠和盲肠细胞增值的测定及全自动化图象分析法的验证
E Persohn,W Seewald,J Bauer et al.
E Persohn et al.
The purpose of this study was to establish and validate fully automatic measurement of cell proliferation on scanned images of rat cecum and colon. Tissue slides were taken from a 4-week mechanistic study and processed for BrdU immunohistoc...