Expression of Ki-67 in the uterus during various stages of the estrous cycle in rats [0.03%]
大鼠动情周期不同阶段子宫Ki-67的表达
Rosemary A Marusak,Zaher A Radi,Leslie Obert
Rosemary A Marusak
Rats have an average estrous cycle of 4-5 days. There are four phases (proestrus, estrus, metesterus, and diestrus) in the estrous cycle in rodents. Histologic staging of the rodent estrous cycle is challenging and requires expertise. Thus,...
Cyclin D1 overexpression in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas [0.03%]
N-甲基-N'-亚硝基胍诱导的大鼠胃腺癌中细胞周期素D1的表达上调
Shinji Takasu,Tetsuya Tsukamoto,Toshikazu Ushijima et al.
Shinji Takasu et al.
Changes in cell cycle regulation are involved in many human cancers, including gastric cancer. In the present study, cyclin D1 expression and localization were immunohistochemically analyzed in 23 N-methyl-N'-nitro-N-nitrosoguanidine-induce...
Expression of epidermal growth factor receptor protein in the liver of db/db mice after partial hepatectomy [0.03%]
部分肝切除后db/db小鼠肝脏表皮生长因子受体蛋白的表达
Makoto Shirai,Hirofumi Yamauchi,Hiroyuki Nakayama et al.
Makoto Shirai et al.
Liver regeneration was impaired after partial hepatectomy (PH) in leptin receptor-deficient db/db mice with severe liver steatosis. In the present study, we analyzed the mode of epidermal growth factor receptor (EGFR) protein expression in ...
Absence of uterine tumours in CD-1 mice treated neonatally with subcutaneous tamoxifen or 4-hydroxyoestradiol [0.03%]
新生小鼠皮下注射他莫昔芬或4-羟基雌二醇后未形成子宫肿瘤
Nihal Razvi,Peter Greaves,Jerry Styles et al.
Nihal Razvi et al.
The effects of subcutaneous dosing of neonatal CD-1 mice with tamoxifen on days 1-5 after birth at doses of 0, 5, 10, 25 or 50 microg/pup or with 4-hydroxyoestradiol at 2 microg/pup have been investigated. Animals were culled at 1.5, 3, 6, ...
Cisplatin-induced nephrotoxicity causes altered renal hemodynamics in Wistar Kyoto and spontaneously hypertensive rats: role of augmented renal alpha-adrenergic responsiveness [0.03%]
顺铂诱导的肾毒性导致Wistar-Kyoto和自发性高血压大鼠肾血液循环改变：增强的肾α-肾上腺素能反应的作用
Md Abdul Hye Khan,Munavvar Abdul Sattar,Nor Azizan Abdullah et al.
Md Abdul Hye Khan et al.
The pathogenesis of cisplatin-induced renal failure is related to reduced renal blood flow due to severe tubular damage and enhanced renovascular resistance. It is also known that alpha(1)-adrenoceptors, the major subtype of alpha-adrenocep...
Urinary metabolic fingerprinting for amiodarone-induced phospholipidosis in rats using FT-ICR MS [0.03%]
傅里叶变换离子回旋共振质谱尿代谢指纹在辨识胺碘酮诱导大鼠发生磷脂osis的研究
Mina Hasegawa,Shigeo Takenaka,Mitsuru Kuwamura et al.
Mina Hasegawa et al.
In the research and development for new therapeutic compounds, there has been a focus on detecting the changes of metabolites induced by drug administration and finding surrogate markers to assess its toxicity. We examined the suitability o...
Satoshi Furukawa,Koji Usuda,Masayoshi Abe et al.
Satoshi Furukawa et al.
In order to investigate the effects of busulfan on the placenta, we examined the sequential histopathological changes in the placenta from rats exposed to busulfan during gestation days (Days) 12-14. Busulfan was intraperitoneally administe...
Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice [0.03%]
左卡尼丁对小鼠急性乙酰氨基酚肝毒性的保护作用研究
Kursad Yapar,Asim Kart,Mahmut Karapehlivan et al.
Kursad Yapar et al.
L-carnitine is a cofactor in the transfer of long-chain fatty acid allowing the beta-oxidation of fatty acid in the mitochondria. It is also a known antioxidant with protective effects against lipid peroxidation. In this study, hepatoprotec...
Effect of cyclophosphamide treatment on selected lysosomal enzymes in the kidney of rats [0.03%]
环磷酰胺对大鼠肾脏某些溶酶体酶的影响研究
Premila Abraham,K Indirani,Emila Sugumar
Premila Abraham
The anti-cancer drug cyclophosphamide (CYP) is nephrotoxic besides being urotoxic thereby limiting its clinical utility. Since the nephrotoxicity of CYP is less common compared to its urotoxicity, not much importance has been given for the ...
DNA ploidy distribution in renal tumours induced in male rats by dietary ochratoxin A [0.03%]
膳食赭曲毒素A诱导雄性大鼠肾肿瘤的DNA倍体分布
Amy L Brown,Edward W Odell,Peter G Mantle
Amy L Brown
DNA ploidy distribution, measured in experimental renal tumours that occurred in twelve ageing male Fischer rats derived from carcinogenicity experiments on ochratoxin A (OTA) in response to chronic dietary exposure, was diploid in all rena...