Intermolecular Stereoselective Iridium-Catalyzed Allylic Alkylation: An Evolutionary Account [0.03%]
铱催化立体选择性分子间烯丙基烷基化反应的演化历程_accounts_of_chemical_research
Samantha E Shockley,J Caleb Hethcox,Brian M Stoltz
Samantha E Shockley
Our lab has long been interested in the development of methods for the creation of enantioenriched all-carbon quaternary stereocenters. Historically, our interest has centered on palladium-catalyzed allylic alkylation, though recent efforts...
Using Chemical Knowledge to Uncover New Biological Function: Discovery of the Cylindrocyclophane Biosynthetic Pathway [0.03%]
运用化学知识发现新的生物功能——环化环烷类生物合成途径的发现
Hitomi Nakamura,Emily P Balskus
Hitomi Nakamura
An understanding of organic chemistry can play a central role in uncovering enzymes with new biochemical functions. We have recently identified the enzymes involved in the biosynthesis of the cylindrocyclophanes, a structurally unique famil...
Synthesis of a C1-C23 fragment of the archazolids and evidence for V-ATPase but not COX inhibitory activity [0.03%]
克雷唑idineC1-C23片段的合成及其V-ATP酶而非COX抑制活性的研究
Gregory W O&#x;Neil,Alexander M Craig,John R Williams et al.
Gregory W O&#x;Neil et al.
A convergent synthesis of a C1-C23 fragment of the archazolids has been completed based on a high yielding Stille coupling to costruct the substituted Z,Z,E-conjugated triene. After removal of the protecting groups, the resulting tetrol exh...
Stephanie W Chun,Alison R H Narayan
Stephanie W Chun
Stereospecific generation of α-amino ketones from common α-amino acids is difficult to achieve, often employing superstoichiometric alkylating reagents and requiring multiple protecting group manipulations. In contrast, the α-oxoamine sy...
Artificial Macrocycles [0.03%]
人工巨环化合物
Eman M M Abdelraheem,Shabnam Shaabani,Alexander Dömling
Eman M M Abdelraheem
Artificial macrocycles recently became popular as a novel research field in drug discovery. As opposed to their natural twins, artificial macrocycles promise to have better control on synthesizability and control over their physicochemical ...
Self-Immolative Prodrugs: Effective Tools for the Controlled Release of Sulfur Signaling Species [0.03%]
自裂解前药：硫信号分子控制释放的有效工具
Kearsley M Dillon,Chadwick R Powell,John B Matson
Kearsley M Dillon
H2S, persulfides (R-SSH), and related sulfur species have recently received attention due to the pronounced physiological effects they elicit. Delivering sulfur signaling molecules in a controlled manner presents many challenges, as many av...
Towards a Catalytic Atroposelective Synthesis of Diaryl Ethers via C(sp 2)-H Alkylation Using Nitroalkanes [0.03%]
通过硝基烷烃介导的C(sp2)氢化作用对 diaryl 醚进行催化的锁住选择性合成研究
Andrew N Dinh,Ryan R Noorbehesht,Sean T Toenjes et al.
Andrew N Dinh et al.
Herein we report studies towards a small molecule catalytic approach to access atropisomeric diaryl ethers that proceeds via a C(sp 2)-H alkylation using nitroalkanes as the alkyl source. A quaternary ammonium salt derived from quinine cont...
Song Hong,Yan Lu,Masao Morita et al.
Song Hong et al.
Maresin-L1 (14S,22-dihydroxy-docosa-4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid) and maresin-L2 (14R,22-dihydroxy-docosa-4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid) were chemically synthesized. They were identical to activated macrophage produced counte...
Diethylzinc-Mediated Metalloamination-Alkylation of N, N-Dimethylhydrazinoalkenes. Catalysis of C-Zn Alkylation Using Simple Cu(I) Salts [0.03%]
N,N-二甲基肼亚烯烃的二乙锌介导的金属胺化-烷基化反应及简单Cu(I)盐催化的C-Zn烷基化反应
Ky Mickelsen,Sean Zabawa,Tom Livinghouse
Ky Mickelsen
Metalloamination-alkylation of representative N,N-dimethyl-hydrazinoalkenes has been shown to be effectively catalyzed by CuBr-SMe2, CuCN, and Cul. The current method obviates the use of stoichiometric CuCN(LiCl)2 as a promoter for the elec...
Asymmetric Alkene and Arene Halofunctionalization Reactions in Meroterpenoid Biosynthesis [0.03%]
倍半萜生物合成中的不对称烯烃和芳烃卤化反应
Bradley S Moore
Bradley S Moore
Meroterpenoid natural products are important bioactive molecules with broad distribution throughout nature. In Streptomyces bacteria, naphthoquinone-based meroterpenoids comprise a simple yet structurally fascinating group of natural produc...