Rational Design of New Dihydrobenzooxophosphole-Based Lewis Base Organocatalysts [0.03%]
新型二氢苯并氧磷olesLewis碱有机催化剂的理性设计
Bo Qu,Lalith P Samankumara,Anjan Saha et al.
Bo Qu et al.
A series of new dihydrobenzooxophosphole-based Lewis Base organocatalysts were designed and synthesized. They are demonstrated effective in trichlorosilane-mediated stereoselective conjugate reductions of C=C bonds. DFT calculations reveal ...
Intramolecular Catalysis of Hydrazone Formation of Aryl-Aldehydes via ortho-Phosphate Proton Exchange [0.03%]
通过ortho-磷酸盐质子交换催化芳香醛肟缩合的分子内催化反应
Ozlem Dile,Anthony M Sorrentino,Susan Bane
Ozlem Dile
Bioorthogonal site-specific chemical reaction to label biomolecules in vitro and in living cells is one of the most powerful and convenient tools in chemical biology. A reactive pairs frequently used for chemical conjugation are aldehydes/k...
Stereoselective α-Tertiary Alkylation of N-(Arylacetyl)oxazolidinones [0.03%]
N-(芳基乙酰)氧杂二环酮的立体选择性α-三级烷基化反应
Eunjae Shim,Armen Zakarian
Eunjae Shim
A method has been developed for the α-tertiary alkylation of zirconium enolates of N-(arylacetyl)oxazolidinones. This reaction directly installs an all-carbon quaternary center vicinal to a benzylic tertiary carbon in a highly diastereosel...
Rh(III)-Catalyzed Cyclopropanation of Unactivated Olefins Initiated by C-H Activation [0.03%]
通过C-H活化催化未活化烯烃的环丙烷化反应
Erik J T Phipps,Tiffany Piou,Tomislav Rovis
Erik J T Phipps
We have developed a Rh(III)-catalyzed cyclopropanation of unactivated olefins initiated by an alkenyl C-H activation. A variety of 1,1-disubstituted olefins undergo efficient cyclopropanation with a slight excess of alkene stoichiometry. A ...
Tyler J Doyon,Alison R H Narayan
Tyler J Doyon
In recent years, there has been a rapid and sustained increase in the development and use of one-pot chemoenzymatic reaction processes for the efficient synthesis of high-value molecules. This strategy can provide a number of advantages ove...
Selective Functionalization of Aliphatic Amines via Myoglobin-catalyzed Carbene N-H Insertion [0.03%]
肌红蛋白催化亚胺基碳正离子与脂肪伯氨的N−H插入选择性官能团化反应
Viktoria Steck,Gopeekrishnan Sreenilayam,Rudi Fasan
Viktoria Steck
Engineered myoglobins have recently gained attention for their ability to catalyze a variety of abiological carbene transfer reactions including the functionalization of amines via carbene insertion into N-H bonds. However, the scope of myo...
Cameron J Pratt,R Adam Aycock,Max D King et al.
Cameron J Pratt et al.
A catalytic system has been developed for the direct alkylation of α-C-H bonds of aniline derivatives with strained C-C σ-bonds. This method operates through a photoredox mechanism in which oxidative formation of aminoalkyl radical interm...
Intermolecular Reactions of Pyridyl Radicals with Olefins via Photoredox Catalysis [0.03%]
光氧化还原催化吡啶基自由基与烯烃的分子间反应研究
Ciaran P Seath,Nathan T Jui
Ciaran P Seath
Pyridines are valuable motifs in a number of bioactive and functional molecules. The chemoselective functionalization of these structures from stable and widely available starting materials is a meaningful goal. We have demonstrated selecti...
Transition-Metal-Free, Visible-Light-Promoted C-S Cross-Coupling through Intermolecular Charge Transfer [0.03%]
无过渡金属参与的可见光促进的通过分子间电荷转移的C-S交叉偶联反应
Bin Liu,Chern-Hooi Lim,Garret M Miyake
Bin Liu
C-S cross-couplings are an important class of reactions applied across organic synthesis, materials science, and pharma-ceuticals. Several different methodologies have been developed to achieve this significant transformation. However, curr...
Jian Wu,Lee Bishop,Jiatong Guo et al.
Jian Wu et al.
The reactions of several β-, γ-, and δ-azido alcohols with dibenzyl and dimethyl N,N-diisopropylphosphoramidites were examined. Detailed analysis of the intermediates and products formed from the reactions under different conditions prov...