Langlang Liu,Yian Guo,Qingchao Liu et al.
Langlang Liu et al.
The total synthesis of endolides A and B has been achieved in a concise, highly stereoselective fashion (12 steps, 16.2% and 16.0% overall yields, respectively). Key features of the route include a modified Negishi coupling between 3-bromof...
Qi Li,Ian B Seiple
Qi Li
Streptogramins are antibiotics produced by several species of Streptomyces bacteria that are used in both human and veterinary medicine. Group A streptogramins comprise 23-membered macrocyclic polyketide/nonribosomal peptide hybrids for whi...
Anti-Markovnikov Hydroazidation of Activated Olefins via Organic Photoredox Catalysis [0.03%]
有机光氧化还原催化活化烯烃的反马尔可夫尼科夫羟基氢叠氮化反应
Nicholas P R Onuska,Megan E Schutzbach-Horton,José L Rosario Collazo et al.
Nicholas P R Onuska et al.
Organic azides serve as synthetically useful surrogates for primary amines, a functional group which is ubiquitous in bioactive and medicinally relevant molecules. Historically, the formal hydroazidation of simple activated olefins and styr...
Synthesis and Characterization of Acridinium Dyes for Photoredox Catalysis [0.03%]
用于光氧化还原催化的吖啶染料的合成与表征
Alexander R White,Leifeng Wang,David A Nicewicz
Alexander R White
Photoredox catalysis is a rapidly evolving platform for synthetic methods development. The prominent use of acridinium salts as a sustainable option for photoredox catalysts has driven the development of more robust and synthetically useful...
Modifying Positional Selectivity in C-H Functionalization Reactions with Nitrogen-Centered Radicals: Generalizable Approaches to 1,6-Hydrogen-Atom Transfer Processes [0.03%]
利用氮中心自由基调控C-H活化中位置选择性：通用的1,6-氢原子转移过程
Melanie A Short,J Miles Blackburn,Jennifer L Roizen
Melanie A Short
Nitrogen-centered radicals are powerful reaction intermediates owing in part to their ability to guide position-selective C(sp3)-H functionalization reactions. Typically, these reactive species dictate the site of functionalization by prefe...
Benjamin T Boyle,J Luke Koniarczyk,Andrew McNally
Benjamin T Boyle
Here we report that N-phosphonium pyridinium intermediates are unusually reactive for pyridine S N Ar reactions. Specifically, forming phosphonium salts from halopyridines typically requires elevated temperatures and Lewis acid additives. T...
Unusual Kinetic Profiles for Lewis Base-Catalyzed Sulfenocyclization of ortho-Geranylphenols in Hexafluoroisopropyl Alcohol [0.03%]
六氟异丙醇中路易斯碱催化正交格尔尼利酚的硫叶立德环化反应的动力学研究
Kevin A Robb,Soumitra V Athavale,Scott E Denmark
Kevin A Robb
The kinetic behavior of the Lewis base-catalyzed sulfenocyclization of polyenes in hexafluoroisopropyl alcohol (HFIP) was explored. The rate of reaction is not dependent on the electronic properties of the terminal nucleophile, suggesting t...
Yusuke Takahira,Miao Chen,Yu Kawamata et al.
Yusuke Takahira et al.
A simple and robust method for electrochemical alkyl C-H fluorination is presented. Using a simple nitrate additive, a widely available fluorine source (Selectfluor), and carbon-based electrodes, a wide variety of activated and unactivated ...
2-Azadienes as Enamine Umpolung Synthons for the Preparation of Chiral Amines [0.03%]
以手性胺的合成为目标的2-偶烯类烯胺 umpolung 反应底物
Steven J Malcolmson,Kangnan Li,Xinxin Shao
Steven J Malcolmson
The development of new strategies for the preparation of chiral amines is an important objective in organic synthesis. In this Synpacts, we summarize our approach for catalytically accessing nucleophilic aminoalkyl metal species from 2-azad...
Asymmetric Reductive Dicarbofunctionalization of Alkenes via Nickel Catalysis [0.03%]
镍催化烯烃的不对称还原双官能化反应
David Anthony,Tianning Diao
David Anthony
Alkenes are an appealing functional group that can be transformed into a variety of structures. Transition-metal catalyzed dicarbofunctionalization of alkenes can efficiently afford products with complex substitution patterns from simple su...