Exploration of Iron- and a-Ketoglutarate-Dependent Dioxygenases as Practical Biocatalysts in Natural Product Synthesis [0.03%]
探索铁和α-酮戊二酸依赖型双加氧酶在天然产物合成中的应用
Hans Renata
Hans Renata
Catalytic C─H oxidation is a powerful transformation with enormous promise to streamline access to complex molecules. In recent years, biocatalytic C─H oxidation strategies have received tremendous attention due to their potential to addr...
Norberto V Orellana,Michael T Taylor
Norberto V Orellana
The chemical modification of tryptophan (Trp) has been the subject of interest for nearly 100 years, yet the development modification conditions that exploit Trp's inherent photolability have remained elusive. In this perspective, we discus...
Nameer Ezzat,Katelyn Bobek,Yu Yuan
Nameer Ezzat
The tropone sesquiterpene phaeocaulisin D, isolated from the rhizomes of Curcuma phaeocaulis, has previously been shown to inhibit nitric oxide production in macrophages. A total synthesis of phaeocaulisin D was accomplished by using an int...
Stereoselective Synthesis of (4 S,5 S)-5-Vinyloxazolidin-2-one-4-carboxylate as a β-Vinylserine Synthetic Equivalent by Vinyl Grignard Addition to an N-Tosyl Version of Garner's Aldehyde [0.03%]
Garner醛的托磺酸酯衍生物与烯基格氏试剂加成构建β-乙烯基丝氨酸衍酸的对映选择性合成研究
Ernest G Nolen,Yuqi M Cao,Brynn D Lewis et al.
Ernest G Nolen et al.
A highly efficient synthesis of a β-vinylserine synthetic equivalent is reported that exploits the stereodirecting effect of the N-toluenesulfonamide in an anti-diastereoselective (8.5:1) vinyl Grignard addition to an analogue of Garner's ...
Harnessing C-O Bonds in Stereoselective Cross-Coupling and Cross-Electrophile Coupling Reactions [0.03%]
在立体选择性交叉偶联和交叉亲电偶联反应中利用C-O键
Amberly B Sanford,Elizabeth R Jarvo
Amberly B Sanford
Herein, we discuss our laboratory's research in the activation of alcohol derivatives in cross-coupling and cross-electrophile coupling reactions. Our developed methods enable the use of secondary alcohols to afford tertiary stereogenic cen...
Margeaux A Miller,Rachael A Day,Daniel A Estabrook et al.
Margeaux A Miller et al.
Fluorophores that are sensitive to their environment are useful tools for sensing chemical changes and probing biological systems. Here, we extend responsive fluorophores to the fluorous phase with the synthesis of a reduction-sensitive flu...
Recent Advances in the Selective Oxidative Dearomatization of Phenols to o-Quinones and o-Quinols with Hypervalent Iodine Reagents [0.03%]
近年来用高碘试剂选择性氧化酚到邻苯醌和邻氢醌的研究进展
Xiao Xiao,Sarah E Wengryniuk
Xiao Xiao
ortho-Quinones are valuable molecular frameworks with diverse applications across biology, materials, organic synthesis, catalysis, and coordination chemistry. Despite their broad utility, their synthesis remains challenging, in particular ...
Racheal M Spurlin,Amber L Harris,Cameron J Pratt et al.
Racheal M Spurlin et al.
Reported here are conditions for the construction of spirocyclic piperidines from linear aryl halide precursors. These conditions employ a strongly reducing organic photoredox catalyst in combination with a trialkylamine reductant to achiev...
C-H Insertion Reactions of Donor/Donor Carbenes: Inception, Investigation, and Insights [0.03%]
供体/供体型卡宾的C-H插入反应：开端、探究和见解
Jared T Shaw
Jared T Shaw
Insertion reactions of donor/donor carbenes have emerged from obscurity to become a versatile method for the synthesis of a variety of cyclic structures with excellent control of diastereo- and enantioselectivity. This Account describes the...
Ryan D Reeves,Caitlin N Kinkema,Eleanor M Landwehr et al.
Ryan D Reeves et al.
Metal-catalyzed allene cycloisomerizations provide rapid entry into five-membered carbocyclic frameworks, a common motif in natural products and pharmaceuticals. While both Au(I) and Pd(0)-catalyzed allene cycloisomerizations give 5-endo-di...