Development of Enantioselective Lithium-Isothiourea-Boronate-Catalyzed Matteson Homologations [0.03%]
手性锂异硫脲硼剂催化的对映选择性Matteson同系化反应的发展研究
Jake Z Essman,Hayden A Sharma,Eric N Jacobsen
Jake Z Essman
Our group's discovery of lithium-isothiourea-boronate-catalyzed Matteson homologations is chronicled. Chiral thiourea dual-hydrogen bond donors were initially found to promote enantioselective dichloromethyl boronate rearrangements, albeit ...
Retrosynthetic Simplicity [0.03%]
合成构思的简洁性
Mark D Levin
Mark D Levin
Retrosynthetic simplicity is introduced as a metric by which methods can be evaluated. An argument in favor of reactions which are retrosynthetically simple is put forward, and recent examples in the context of skeletal editing from my own ...
Asymmetric Catalytic Hydroboration of Enol Carbamates Enables an Enantioselective Matteson Homologation [0.03%]
enaminate 碳酸酯的不对称催化氢硼化实现高立体选择性的 Matteson 同位素反应
Dmitry M Kuznetsov,Joseph M Ready
Dmitry M Kuznetsov
Rh-catalyzed asymmetric hydroboration of enol carbamates yields α-boryl carbamates in good enantioselectivity. The enol carbamate starting materials can be prepared with moderate Z selectivity using a modified Juila olefination and used as...
Hyelee Lee,Marisol Alvarado,Sarah Ingram et al.
Hyelee Lee et al.
General protocols for the N-functionalization of 1,2-azaborines with C(sp3), C(sp2), or C(sp) electrophiles are described. The syntheses of a new parental BN isostere of trans-stilbene and a BN isostere of a lisdexamfetamine derivative were...
Photoredox-Catalyzed Radical-Radical Coupling of Potassium Trifluoroborates with Acyl Azoliums [0.03%]
光氧化还原催化酰基唑
Michael J Rourke,Matthew J McGill,Daniel Yang et al.
Michael J Rourke et al.
Potassium trifluoroborates have gained significant utility as coupling partners in organic synthesis, particularly in the Suzuki-Miyaura coupling reaction. Recently, they have also been used as radical precursors under oxidative conditions ...
Enamine N-oxides: Design, Synthesis, and Function in Bioorthogonal Reactions [0.03%]
エンアミンN-氧化物：设计、合成及生物正交反应中的功能
Dahye Kang,Justin Kim
Dahye Kang
Enamine N-oxides act as a chemical linchpin bridging two bioorthogonal associative and dissociative reactions. This article describes the design of enamine N-oxides; their synthesis through the retro-Cope elimination reaction; the use of so...
Spectral and Electrochemical Properties of Common Photocatalysts in Water: A Compendium for Aqueous Photoredox Catalysis [0.03%]
常见光催化剂在水相中的光谱及电化学性质：水相光电催化小结
Samuel Gary,Melinda Landry,Steven Bloom
Samuel Gary
Electrochemical potentials of photocatalysts are solvent dependent. One of the largest discrepancies is observed when water is used in place of organic solvents as the reaction media. Unfortunately, the redox potentials for many photocataly...
Mónica Rivas,Vladimir Gevorgyan
Mónica Rivas
This Account summarizes efforts in our group toward synthesis of heterocycles in the past decade. Selected examples of transannulative heterocyclizations, intermediate construction of reactive compounds en route to these important motifs, a...
Bryce T Nicholls,Tianzhang Qiao,Todd K Hyster
Bryce T Nicholls
Reductive radical cyclizations are ubiquitous in organic synthesis and have been applied to the synthesis of structurally complex molecules. N-heterocyclic motifs can be prepared through the cyclization of α-haloamides; however, slow rotat...
Development of New Reactions Driven by N-O Bond Cleavage: from O-Acyl Hydroxylamines to Tetrodotoxin [0.03%]
由N=O键裂解驱动的新反应的发展：从O-酰基羟胺到河豚毒
Jacob G Robins,Jeffrey S Johnson
Jacob G Robins
This Account describes new reactions that have been developed in the Johnson laboratories at UNC Chapel Hill enabled by considerations of N-O bond cleavage. Three main case studies are highlighted: the metal-catalyzed electrophilic aminatio...