Quercetin but not luteolin suppresses the induction of lethal shock upon infection of mice with Salmonella typhimurium [0.03%]
槲皮素抑制鼠伤寒沙门氏菌感染诱导的致死性休克而不像芹菜素
Tsuyoshi Sugiyama,Kiichiro Kawaguchi,Hideki Dobashi et al.
Tsuyoshi Sugiyama et al.
Tumor necrosis factor-alpha (TNF-alpha) is important for the induction of systemic inflammatory responses that lead to lethal shock. Quercetin and luteolin, which differ by one hydroxyl group, are known to suppress the lipopolysaccharide-in...
Simultaneous single-tube PCR-based assay for the direct identification of the five most common meningococcal serogroups from clinical samples [0.03%]
一种临床样本中五种流行脑膜炎奈瑟菌菌群直接鉴定的单管同时PCR检测方法
Zacharoula Drakopoulou,Konstantinos Kesanopoulos,Maria Sioumala et al.
Zacharoula Drakopoulou et al.
This study presents a stepdown multiplex PCR assay for the simultaneous detection of the five most common Neisseria meningitidis serogroups (A, B, C, W-135 and Y) in 530 clinical samples obtained from 428 patients (271 blood and 259 cerebro...
Rapid and simple detection of eight major periodontal pathogens by the loop-mediated isothermal amplification method [0.03%]
利用环介导等温扩增技术快速简便地检测八大常见牙周病病原体
Junko Miyagawa,Hiroshi Maeda,Toshimitsu Murauchi et al.
Junko Miyagawa et al.
Loop-mediated isothermal amplification (LAMP) was applied to develop a rapid and simple detection system for eight periodontal pathogens: Aggregatibacter (Actinobacillus) actinomycetemcomitans, Campylobacter rectus, Eikenella corrodens, Fus...
Congenital asplenia and group B streptococcus sepsis in the adult: case report and review of the literature [0.03%]
成人先天性无脾症合并B群链球菌败血症之病例报告与文献回顾
Kumaran Thiruppathy,Antonio Privitera,Kapila Jain et al.
Kumaran Thiruppathy et al.
Asplenia is associated with an increased incidence of fatal and life-threatening sepsis caused by encapsulated pathogens. Isolated congenital asplenia is a very rare condition, with only 33 cases reported in the literature. The authors repo...
Leptospira interrogans is recognized through DC-SIGN and induces maturation and cytokine production by human dendritic cells [0.03%]
里氏利斯特菌通过DC-SIGN被识别，并能诱导人类树突状细胞成熟及产生白细胞介素
Narintorn Gaudart,Pattama Ekpo,Kovit Pattanapanyasat et al.
Narintorn Gaudart et al.
Leptospirosis is a global zoonotic disease, caused by pathogenic Leptospira species including Leptospira interrogans, that causes public health and livestock problems. Pathogenesis, immune response and cellular receptors for Leptospira are ...
Evidence of horizontal gene transfer between human and animal commensal Escherichia coli strains identified by microarray [0.03%]
通过基因芯片技术鉴定人与动物共生型大肠杆菌菌株间的水平基因转移事件
Elena Grasselli,Patrice François,Michaela Gutacker et al.
Elena Grasselli et al.
Bacteria exchange genetic material by horizontal gene transfer (HGT). To evaluate the impact of HGT on Escherichia coli genome plasticity, 19 commensal strains collected from the intestinal floras of humans and animals were analyzed by micr...
Investigation of virulence genes in clinical isolates of Yersinia enterocolitica [0.03%]
致病性耶尔森氏小肠结肠炎耶尔森菌毒力基因的分布研究
Haoxuan Zheng,Yong Sun,Zhengguo Mao et al.
Haoxuan Zheng et al.
In this study, we aimed to investigate the distribution of virulence genes in clinical isolates of pathogenic Yersinia enterocolitica. Two thousand six hundred stool samples were collected from 2600 patients with diarrhea, and were tested u...
Telithromycin inhibits the production of proinflammatory mediators and the activation of NF-kappaB in in vitro-stimulated murine cells [0.03%]
泰利霉素抑制四氮茋所致的小鼠细胞NF-κB活化及促炎介质生成的作用研究
Magdalena Leiva,Alfonso Ruiz-Bravo,Encarnación Moreno et al.
Magdalena Leiva et al.
Telithromycin is a ketolide antibiotic with anti-inflammatory properties. To investigate the mechanisms of these effects, we examined the in vitro immunomodulatory activity of telithromycin on murine splenocytes and the murine macrophage ce...
The sequence of the acidic repeat protein (arp) gene differentiates venereal from nonvenereal Treponema pallidum subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis [0.03%]
酸性重复蛋白（ARP）基因的序列差异可区分梅毒螺旋体亚种中的性传播与非性传播类型，并且在导致梅毒的菌株中，该基因在正向选择的强大作用下发生进化
Kristin N Harper,Hsi Liu,Paolo S Ocampo et al.
Kristin N Harper et al.
Despite the completion of the Treponema pallidum genome project, only minor genetic differences have been found between the subspecies that cause venereal syphilis (ssp. pallidum) and the nonvenereal diseases yaws (ssp. pertenue) and bejel ...
The withdrawal of antimicrobial treatment as a mechanism for defeating resistant microorganisms [0.03%]
停用抗菌药物治疗以战胜耐药微生物的新机制
David J Stokes,Alison F Kelly,Simon W J Gould et al.
David J Stokes et al.
Antimicrobial resistance is a major concern in health care and farming settings throughout the world. The level of antimicrobial resistance continues to increase and the requirement for a novel and possibly dramatic change in therapy choice...