Pharmacological and molecular enhancement of learning in aging and Alzheimer's disease [0.03%]
药物和分子在衰老和阿尔茨海默病中增强学习能力
John F Disterhoft,M Matthew Oh
John F Disterhoft
When animals learn hippocampus-dependent associative and spatial tasks such as trace eyeblink conditioning and the water maze, CA1 hippocampal neurons become more excitable as a result of reductions in the post-burst, slow afterhyperpolariz...
Light-regulated translocation of signaling proteins in Drosophila photoreceptors [0.03%]
果蝇光受体中信号蛋白的光调控重新分布现象
Shahar Frechter,Baruch Minke
Shahar Frechter
Illumination of Drosophila photoreceptor cells induces multi-facet responses, which include generation of the photoreceptor potential, screening pigment migration and translocation of signaling proteins which is the focus of recent extensiv...
Gliotransmission at central glutamatergic synapses: D-serine on stage [0.03%]
中枢谷氨酸能突触中的胶质递质传递：D-丝氨酸登场
Magalie Martineau,Gérard Baux,Jean-Pierre Mothet
Magalie Martineau
Long ignored and only considered as housekeeping cells for neurons, astroglial cells in the last decade have gained increasing attention as key players of higher functions in healthy brain, but also in diseases. This revolution in our way t...
Early abnormalities in transgenic mouse models of amyotrophic lateral sclerosis [0.03%]
渐冻症转基因鼠模型中的早期异常现象
Jacques Durand,Julien Amendola,Cyril Bories et al.
Jacques Durand et al.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative and fatal human disorder characterized by progressive loss of motor neurons. Transgenic mouse models of ALS are very useful to study the initial mechanisms underlying this neurodege...
Salvatore Oddo,Frank M LaFerla
Salvatore Oddo
The two hallmark lesions of Alzheimer's disease (AD) are extracellular amyloid plaques, mainly formed by a small peptide called amyloid-beta (Abeta), and neurofibrillary tangles, which are intracellular inclusions formed by aggregates of hy...
Keith J Todd,Alexandre Serrano,Jean-Claude Lacaille et al.
Keith J Todd et al.
Plasticity of synaptic transmission is believed to be the cellular basis for learning and memory, and depends upon different pre- and post-synaptic neuronal mechanisms. Recently, however, an increasing number of studies have implicated a th...
Long term recordings with microelectrode arrays: studies of transcription-dependent neuronal plasticity and axonal regeneration [0.03%]
长期微电极阵列记录：转录依赖的神经可塑性和轴突再生研究
Frank Hofmann,Hilmar Bading
Frank Hofmann
Substrate integrated microelectrode arrays (MEAs) offer an alternative to classical electrophysiological methods like the patch clamp technique for recording the electrical activity from cells and tissue of neuronal or cardiac origin. Since...
A role for the protein phosphatase 2B in altered hippocampal synaptic plasticity in the aged rat [0.03%]
蛋白磷酸酶2B在衰老大鼠海马突触可塑性改变中的作用
Anne Jouvenceau,Patrick Dutar
Anne Jouvenceau
Synaptic plasticity following NMDA application on hippocampal slices from young (3-5 months) and aged (24-27 months) rats was compared. In young rats, NMDA (20 microM) induced opposite effects depending on the duration of the application. A...
Gertrudis Perea,Alfonso Araque
Gertrudis Perea
Glial cells were classically considered as supportive cells that do not contribute to information processing in the nervous system. However, considerable amount of evidence obtained by several groups during the last few years has demonstrat...
Synaptic remodeling induced by axotomy of superior cervical ganglion neurons: Involvement of metalloproteinase-2 [0.03%]
superior cervical ganglion 轴突切断诱发的神经元的突触重塑：金属蛋白酶-2的参与
Paola Paggi,Maria Egle De Stefano,Tamara Corinna Petrucci
Paola Paggi
We previously demonstrated the involvement of the dystrophin-dystroglycan (Dys-DG) complex in the stabilization of intraganglionic synapses in rodent superior cervical ganglion (SCG) by investigating changes in the organization of their pos...