Samantha Sigurdson,Stephane Thibodeau,Martin Korzeniowski et al.
Samantha Sigurdson et al.
Radiotherapy is an integral part of the multidisciplinary management of breast cancer (BC). There have been multiple recent advances in the delivery of radiotherapy, reviewed with a critical discussion of the evidence from trials investigat...
Estimating the Benefit of Preoperative Systemic Therapy to Reduce the Extent of Breast Cancer Surgery: Current Standard and Future Directions [0.03%]
评估新辅助全身治疗减少乳腺癌手术范围的益处：现状与未来方向
Giacomo Montagna
Giacomo Montagna
Once reserved for locally advanced tumors which were deemed inoperable at presentation, preoperative systemic therapy (PST) is nowadays increasingly used to treat early breast cancer. PST allows for in vivo assessment of tumor response, for...
Assessment and Response to Neoadjuvant Treatments in Breast Cancer: Current Practice, Response Monitoring, Future Approaches and Perspectives [0.03%]
乳腺癌新辅助治疗的评估和反应：目前的实践，反应监测，未来的方法和展望
Vincenzo Sabatino,Alma Pignata,Marvi Valentini et al.
Vincenzo Sabatino et al.
Neoadjuvant treatments (NAT) for breast cancer (BC) consist in the administration of chemotherapy-more rarely endocrine therapy-before surgery. Firstly, it was introduced 50 years ago to downsize locally advanced (inoperable) BCs. NAT are n...
Transversal Perspectives of Integrative Oncology Care in Gastric and Lobular Breast Cancer [0.03%]
胃癌和小叶乳腺癌整合肿瘤学护理的横向视角
Emilio Francesco Giunta,Gianluca Arrichiello,Annalisa Pappalardo et al.
Emilio Francesco Giunta et al.
The occurrence of gastric cancer has been associated with an increased risk of lobular breast tumors in a subset of patients harboring selected germline mutations. Among all, the germline alteration of the gene coding for E-Cadherin (CDH1) ...
Screening Programs for Breast Cancer: Toward Individualized, Risk-Adapted Strategies of Early Detection [0.03%]
乳腺癌筛查项目：迈向个体化的风险适应性早期检测策略
Dario Trapani,Josè Sandoval,Pamela Trillo Aliaga et al.
Dario Trapani et al.
Early detection of breast cancer (BC) comprises two approaches: screening of asymptomatic women in a specified target population at risk (usually a target age range for women at average risk), and early diagnosis for women with BC signs and...
Immune-Checkpoint Inhibitors: A New Line of Attack in Triple-Negative Breast Cancer [0.03%]
免疫检查点抑制剂：三阴性乳腺癌的新攻击手段
Ouissam Al Jarroudi,Khalid El Bairi,Giuseppe Curigliano et al.
Ouissam Al Jarroudi et al.
Poor prognosis is a distinctive feature of triple-negative breast cancer (TNBC). Chemotherapy has long represented the main and unique treatment for patients with TNBC. Recently, immune checkpoint inhibitors (ICIs) were investigated in seve...
Antibody-Drug Conjugates: A New Therapeutic Approach for Triple-Negative Breast Cancer [0.03%]
抗体药物偶联物：三阴性乳腺癌的新治疗方案
Ouissam Al Jarroudi,Khalid El Bairi,Giuseppe Curigliano et al.
Ouissam Al Jarroudi et al.
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subset associated with a worse prognosis and poor response to conventional chemotherapy. Despite recent advances in drug discovery, its management is still a challenge for ...
Inferring the Cancer Cellular Epigenome Heterogeneity via DNA Methylation Patterns [0.03%]
基于DNA甲基化模式推理癌症细胞表观基因组异质性
Sheng Li
Sheng Li
Tumor cells evolve through space and time, generating genetically and phenotypically diverse cancer cell populations that are continually subjected to the selection pressures of their microenvironment and cancer treatment. ...
Yadong Wang,Xujun Wang,Jun Lu
Yadong Wang
The Ten-Eleven-Translocation (TET) family of genes, including TET1, TET2, and TET3, play critical roles in the oxidation of 5-methylcytosine marks in both DNA and RNA, thereby regulating the epigenome and epitranscriptome in cells. These ge...
Chenxi Xu,Shuai Zhao,Ling Cai
Chenxi Xu
Prostate cancer (PCa) is a heterogeneous disease exhibiting both genetic and epigenetic deregulations. Epigenetic alterations are defined as changes not based on DNA sequence, which include those of DNA methylation, histone modification, an...