Davide Bedognetti,Alessandra Cesano,Francesco M Marincola et al.
Davide Bedognetti et al.
The development of cancer results from the evolutionary balance between the proliferating aptitude of cancer cells and the response of the host's tissues. Some cancers are characterized by genetic instability dependent upon impaired DNA rep...
Han,Lotze
Han
The adaptive immune response is a 500-million-year-old (the "Big Bang" of Immunology) collective set of rearranged and/or selected receptors capable of recognizing soluble and cell surface molecules or shape (B cells, antibody), endogenous ...
Lei Wang,Peter P Lee
Lei Wang
It is increasingly recognized that cancer does not involve only formation of a tumor, but also systemic changes in the host. Alterations in number, spatial relationship, and function of immune cells have been identified in cancer patients' ...
George McNamara,Justin Lucas,John F Beeler et al.
George McNamara et al.
The premise of this book is the importance of the tumor microenvironment (TME). Until recently, most research on and clinical attention to cancer biology, diagnosis, and prognosis were focused on the malignant (or premalignant) cellular com...
Mohammad Haris,Sabah Nisar,Sheema Hashem et al.
Mohammad Haris et al.
Noninvasive imaging of functional and molecular changes in cancer has become an indispensable tool for studying cancer in vivo. Targeting the functional and molecular changes in cancer imaging provides a platform for the in vivo analysis of...
Simon Mantha
Simon Mantha
Cancer can be associated with several distinct coagulation defects which can lead to bleeding complications. The primary hyperfibrinolytic syndrome associated with acute promyelocytic leukemia has been well recognized and is one of the most...
Charlene Mantia,Jeffrey I Zwicker
Charlene Mantia
Venous thromboembolism is commonly diagnosed in patients with primary and secondary brain tumors. Anticoagulation management in the setting of brain tumors is complicated by the high background rate of spontaneous intracranial hemorrhage. U...
Thrombosis in the Philadelphia Chromosome-Negative Myeloproliferative Neoplasms [0.03%]
费城染色体阴性骨髓增生性肿瘤的血栓形成事件
Kamya Sankar,Brady L Stein,Raajit K Rampal
Kamya Sankar
The myeloproliferative neoplasms (MPNs) are clonal stem cell-derived diseases. This chapter focuses on the subcategory of Philadelphia (Ph) chromosome-negative classical MPNs, polycythemia vera (PV), essential thrombocythemia (ET), primary ...
Mari R Thomas,Marie Scully
Mari R Thomas
Thrombotic microangiopathy (TMA) is a syndrome involving fragmentation haemolysis, thrombocytopenia, and thrombosis. A range of disorders including cancer may have TMA as a clinical manifestation. TMA in cancer may be caused by several mech...
Jodi V Mones,Gerald Soff
Jodi V Mones
Chemotherapy-induced thrombocytopenia (CIT) is a frequent complication of cancer therapy, leading to increased risk of bleeding, when the thrombocytopenia is severe (