Aganta Chakraborty,Sanket Pramanik,Shrabasti Mullick et al.
Aganta Chakraborty et al.
Glutamine is crucial for cancer cell proliferation and survival because it fuels the TCA cycle, provides building blocks for macromolecules, and helps maintain redox balance by supporting antioxidant pathways like glutathione production. Ca...
Bhupender Nehra,Sourabh Suthar,Rishabh Kasnia et al.
Bhupender Nehra et al.
A basic metabolic characteristic of carcinogenesis, namely the Warburg effect, is defined by the preferred utilization of aerobic glycolysis for energy generation in cancer cells, even in the presence of oxygen. Here, rapid proliferation an...
Gomathi Mohan,Mukesh Meena,Manzer H Siddiqui et al.
Gomathi Mohan et al.
The fact that tumor cells have a distinct metabolic phenotype from their normal equivalents is becoming more widely recognized. Tumor metabolism exhibits a complex ecological network due to the presence of multiple metabolic compartments in...
Phenotypic Plasticity, Non-genetic Mechanisms, and Immune Drug Resistance in Cancer [0.03%]
癌症的表型可塑性、非遗传机制和免疫药物耐药性
Prakash Kulkarni,Sravani Ramisetty,Debora Bruno et al.
Prakash Kulkarni et al.
Cancer immunotherapy is a major advancement in the field. It works by stimulating the patient's immune system to recognize and destroy cancer cells. Several different types of cancer immunotherapies have been developed, such as T-cell thera...
Miguel Zugman,Salvador Jaime-Casas,Peter D Zang et al.
Miguel Zugman et al.
There have been tremendous advancements in immunotherapy approaches for patients with renal cell carcinoma (RCC) from the initial interleukin-2 era to the current immune checkpoint inhibitor (ICI) combinations. Several ICI-based therapies h...
Advancing Prostate Cancer Treatment: Innovations and Challenges in Immunotherapy [0.03%]
前列腺癌治疗的免疫疗法创新与挑战
Gargi Singhal,Pankaj Garg,Atish Mohanty et al.
Gargi Singhal et al.
Prostate cancer (PCa), a leading cause of cancer mortality in men, has experienced a paradigm shift with the rise of immunotherapy. This chapter examines the immunological landscape of PCa and highlights key immunotherapeutic approaches, in...
Krushangi Patel,Percy Lee,Julius Weng et al.
Krushangi Patel et al.
Immunotherapeutic approaches have created effective therapy with a manageable toxicity profile as a new treatment approach in a wide variety of cancers, often leading to longer responses and control of disease. In pancreatic cancer, respons...
Role of Immunotherapy in Ovarian Cancer: Advances, Challenges, and Future Perspectives [0.03%]
免疫治疗在卵巢癌中的作用：进展、挑战和未来展望
Pankaj Garg,Gargi Singhal,Siddhika Pareek et al.
Pankaj Garg et al.
Ovarian cancer (OC) remains one of the most challenging gynecologic malignancies due to its late-stage diagnosis, high recurrence rates, and limited survival outcomes. Immunotherapy has emerged as a transformative approach in cancer treatme...
Immunotherapy in Melanoma [0.03%]
黑色素瘤的免疫治疗
Yan Xing,Helena T Wu,Swapnil Rajurkar et al.
Yan Xing et al.
This chapter explores systemic treatment strategies for cutaneous melanoma across neoadjuvant, adjuvant, and Stage IV settings. Neoadjuvant therapy aims to reduce tumor burden pre-surgery, primarily using immune checkpoint inhibitors like n...
Novel Immune Modulatory Agents in the Treatment of Non-small Cell Lung Cancer [0.03%]
新型免疫调节剂在非小细胞肺癌治疗中的应用
Amanda Reyes,Matthew Lee
Amanda Reyes
Lung cancer is the leading cause of cancer-related mortality worldwide. Non-small cell lung cancer (NSCLC) makes up the large majority of lung cancer diagnoses. After the discovery of immune modulators or immunotherapy, treatments that coul...