Haris Ali,Vinod Pullarkat,David Snyder
Haris Ali
The classical myeloproliferative neoplasms (MPN) are characterized by clonal expansion of one or more hematopoietic cell lineages and are driven by mutations that activate constitutive signaling via JAK2 pathway. The criteria for diagnosis ...
Tanya Siddiqi
Tanya Siddiqi
Chronic lymphocytic leukemia (CLL), the most common leukemia in the western world, is characterized by the accumulation of monoclonal B-lymphocytes in the bone marrow and lymphoid organs. Signaling via the B-cell receptor and Bruton tyrosin...
Current Management and New Developments in the Treatment of Myelodysplastic Syndrome [0.03%]
骨髓增生异常综合征的治疗现状及进展
Shukaib Arslan,Samer Khaled,Ryotaro Nakamura
Shukaib Arslan
Myelodysplastic syndrome (MDS) is a heterogeneous hematological neoplasm with a wide range of clinical presentations from isolated anemia to pancytopenia and propensity to transform to acute myeloid leukemia. MDS is characterized by morphol...
CML Chapter [0.03%]
CML章节
David Snyder
David Snyder
The discovery of the tyrosine kinase inhibitor (TKI) imatinib in the early 2000's revolutionized the treatment and prognosis of patients with chronic myeloid leukemia (CML) [Hochhaus et al. in N Engl J Med 376:917-927, 2017]. The treatment ...
Justin Darrah,Weili Sun
Justin Darrah
With the recent advent of newer targeted therapies, including blinatumomab, inotuzumab ozogamicin, tyrosine kinase inhibitors (TKIs), and CAR T cells, treatment approaches to newly diagnosed as well as relapsed/refractory acute lymphoblasti...
Brian Ball,Matthew Mei,Salman Otoukesh et al.
Brian Ball et al.
Acute myeloid leukemia (AML) is predominantly a disease of older adults and the majority of affected patients succumb to the disease. After decades of slow progress, the last 5 years have witnessed remarkable progress in AML therapy with th...
Acute Promyelocytic Leukemia: Update on Risk Stratification and Treatment Practices [0.03%]
急性早幼粒细胞性白血病：危险度分层及治疗方案的更新
Amandeep Salhotra,Matthew Mei
Amandeep Salhotra
Acute promyelocytic leukemia (APL) is a rare but highly curable form of acute myeloid leukemia (AML) whose genetic hallmark is the balanced reciprocal translocation t(15;17)(q22;q12) which fuses the promyelocytic leukemia (PML) and retinoic...
Michelle Afkhami,Feras Ally,Vinod Pullarkat et al.
Michelle Afkhami et al.
Our understanding of the genetics and biology of lymphoblastic leukemia/lymphoma (acute lymphoblastic leukemia, ALL) has advanced rapidly in the past decade with advances in sequencing and other molecular techniques. Besides recurrent chrom...
Advances in Diagnosis and Risk Stratification of Acute Myeloid Leukemia and Myelodysplastic Syndromes [0.03%]
急性髓细胞性白血病和骨髓增生异常综合症的诊断和风险分层的进展
Raju K Pillai,Michelle Afkhami
Raju K Pillai
Advances in high-throughput DNA sequencing technology in the past decade have made a tremendous impact on basic science and clinical practice. Methods using the latest next generation sequencing technology can sequence an entire human genom...
Anna Woodbury,Bati Myles
Anna Woodbury
Integrative medicine is an approach to medical care that embraces all effective therapies including complementary treatments such as acupuncture and hypnosis. There is growing use of complementary therapies in the cancer patient population,...