Translating Research into Health Policy: The Citizen Petition Experience with the Food and Drug Administration [0.03%]
将研究转化为卫生政策：民众向食品和药物管理局提出的请愿个案体验
Paul Ray,Charles L Bennett
Paul Ray
Translating research findings into policy is important. Health policy researchers often testify before Congressional subcommittees and provide background on health policy issues. A rarely used, but important, tool for facilitating translati...
Policing of Drug Safety Information Dissemination Under the False Claims Act [0.03%]
根据《虚假索赔法》对药物安全信息传播的监管
Brian Chen,Tony Yang,Charles L Bennett
Brian Chen
On July 25, 2017, the second largest multi-million dollar settlement was pursued with the assistance of the Department of Justice and alleging inappropriate marketing strategies utilized by the pharmaceutical industry came to an end. ...
Biosimilar Epoetin in the United States: A View from the Southern Network on Adverse Reactions [0.03%]
美国的生物类似药Epoetin：来自南方网络不良反应的观点
Sumimasa Nagai,Bartlett Witherspoon,Chadi Nabhan et al.
Sumimasa Nagai et al.
Biosimilar drugs, close copies of patented biologicals, are intended to provide access to less expensive, highly similar versions of reference (previously approved) biological agents (Kozlowski et al. in N Engl J Med 365:385-388, 2011). The...
Fluoroquinolone-Associated Disability and Other Fluoroquinolone-Associated Serious Adverse Events: Unexpected Toxicities Have Emerged in Recent Years [0.03%]
氟喹诺酮相关残疾及其他氟喹诺酮类严重不良事件：近年来出现的意外毒性反应
Charles L Bennett,Oscar Champigneulle,Andrew Bennett et al.
Charles L Bennett et al.
This study describes cases of individuals who report adverse events following consumption of the most commonly prescribed fluoroquinolone (FQ) antibiotics: ciprofloxacin, levofloxacin, or moxifloxacin. Fluoroquinolone (FQ) antibiotics are s...
Clinical Development and Therapeutic Applications of Bispecific Antibodies for Hematologic Malignancies [0.03%]
双特异抗体在血液系统恶性肿瘤中的临床开发和治疗应用
Priya Hays
Priya Hays
Bispecific antibodies are composed of two monoclonal antibodies that engage T cells with tumor cell antigens and lead to tumor cell lysis. The most common types fall into the category of bispecific T cell engagers, or BiTEs, that have the c...
The Single-Cell Level Perspective of the Tumor Microenvironment and Its Remodeling by CAR-T Cells [0.03%]
CAR-T细胞重编程肿瘤微环境的单细胞水平视角
Sanxing Gao,Ryohichi Sugimura
Sanxing Gao
The tumor microenvironment (TME) is a complex milieu consisting of lymphoid cells, myeloid cells, fibroblasts, and multiple molecules, which play a key role in tumor progression and immunotherapy. TME is characterized by immune-suppressive ...
Off-the-Shelf Chimeric Antigen Receptor Immune Cells from Human Pluripotent Stem Cells [0.03%]
由人类多能干细胞制备即用型嵌合抗原受体免疫细胞
Handi Cao,Ryohichi Sugimura
Handi Cao
Autologous chimeric antigen receptor (CAR) T cells have expanded the scope and therapeutic potential of anti-cancer therapy. Nevertheless, autologous CAR-T therapy has been challenging due to labor some manufacturing processes for every pat...
Fabiana Perna,Manuel R Espinoza-Gutarra,Giuseppe Bombaci et al.
Fabiana Perna et al.
Acute myeloid leukemia (AML) is an aggressive, clonally heterogeneous, myeloid malignancy, with a 5-year overall survival of approximately 27%. It constitutes the most common acute leukemia in adults, with an incidence of 3-5 cases per 100,...
Immunotherapy in Genitourinary Malignancy: Evolution in Revolution or Revolution in Evolution [0.03%]
泌尿生殖系统肿瘤的免疫治疗：渐变还是突变？
Kevin Lu,Kun-Yuan Chiu,Chen-Li Cheng
Kevin Lu
Immunotherapy, the 5th pillar of cancer care after surgery, radiotherapy, cytotoxic chemotherapy, and precision therapy (molecular targeted therapy), is revolutionizing the standard of care in certain patients with genitourinary malignancie...
Francesca Aroldi,Reem Saleh,Insiya Jafferji et al.
Francesca Aroldi et al.
The introduction of immune checkpoint inhibitors represented a breakthrough treatment for metastatic melanoma, but the effect of these agents is not limited to a single cancer type. Promising results have been reported in various solid tumo...