Joseph R Lakowicz,Jonathan D Dattelbaum,Ignacy Gryczynski
Joseph R Lakowicz
We describe a new method which allows quantitative measurements of fluorescence intensity in highly scattering media. The measurement principle is based on observing the emission from both the fluorophore of interest with a nanosecond decay...
Detection of the sickle hemoglobin allele using a surface plasmon resonance based biosensor [0.03%]
基于表面等离子共振生物传感器的镰状细胞贫血基因型检测方法研究
Giulia Breveglieri,Elisabetta D&#x;Aversa,Lucia Carmela Cosenza et al.
Giulia Breveglieri et al.
Sickle Cell Disease (SCD) is a monogenic hereditary blood disorder caused by a single point mutation (βS) in the β globin gene resulting in an abnormal hemoglobin (HbS) that can polymerize within the erythrocytes, inducing their character...
A wavelength-ratiometric fluoride-sensitive probe based on the quinolinium nucleus and boronic acid moiety [0.03%]
一种基于喹啉
Ramachandram Badugu,Joseph R Lakowicz,Chris D Geddes
Ramachandram Badugu
We report a new water-soluble fluorescent probe sensitive to aqueous fluoride. The probe shows spectral shifts and intensity changes in the presence of fluoride, in a wavelength ratiometric and colorimetric manner, enabling the detection of...
Photonic Crystal-Enhanced Fluorescence Imaging Immunoassay for Cardiovascular Disease Biomarker Screening with Machine Learning Analysis [0.03%]
结合机器学习分析的光子晶体增强荧光免疫检测技术用于心血管疾病生物标志物筛选
Kenneth J Squire,Yong Zhao,Ailing Tan et al.
Kenneth J Squire et al.
When myocardial walls experience stress due to cardiovascular diseases, like heart failure, hormone N-terminal pro-B-type natriuretic peptide (NT-proBNP) is secreted into the blood. Early detection of NT-proBNP can assist diagnosis of heart...
Nanostructured Diatom-ZrO2 composite as a selective and highly sensitive enzyme free electrochemical sensor for detection of methyl parathion [0.03%]
用于检测甲基-parathion的选择性且灵敏度高的无酶电化学传感器的纳米结构硅藻-氧化锆复合材料
Krishna Prasad Gannavarapu,V Ganesh,Megha Thakkar et al.
Krishna Prasad Gannavarapu et al.
In the current work we report a simple and scalable technique for synthesis of ordered nanoporous Si-ZrO2 composite derived from the diatom Phaeodactylum tricornutum. The composite was well characterized using SEM, TEM-EDX, FTIR, TGA, BET a...
Bright red-emitting highly reliable styryl probe with large Stokes shift for visualizing mitochondria in live cells under wash-free conditions [0.03%]
一种高性能的具有大斯托克斯位移的茋类探针用于在无洗涤条件下活细胞中线粒体的发光成像研究
Chathura S Abeywickrama,Kaveesha J Wijesinghe,Robert V Stahelin et al.
Chathura S Abeywickrama et al.
Bright red-emitting pyridinium cyanine based styryl probe 2 is synthesized in good yields. Probe 2 demonstrated a large Stokes' shift (Δλ ≈ 128 nm, 4227 cm-1 in DCM) and excellent fluorescent quantum yield (ϕfl ≈ 0.2 - 0.7) due to stro...
Anti-myeloma activity and molecular logic operation by Natural Killer cells in microfluidic droplets [0.03%]
基于微流体液滴的自然杀伤细胞的抗多发性骨髓瘤活性及分子逻辑运算
Saheli Sarkar,Seamus McKenney,Pooja Sabhachandani et al.
Saheli Sarkar et al.
Immune-targeted therapies that activate effector lymphocytes such as Natural Killer (NK) cells are currently being investigated for the treatment of Multiple myeloma (MM), the second most common form of hematological cancer. However, indivi...
Near-infrared fluorescent probes with BODIPY donors and rhodamine and merocyanine acceptors for ratiometric determination of lysosomal pH variance [0.03%]
用于测定溶酶体pH变化的比率型近红外荧光探针（含BODIPY供体和罗丹明及花青受体）
Shuai Xia,Mingxi Fang,Jianbo Wang et al.
Shuai Xia et al.
Three fluorescent probes have been developed by conjugating three different BODIPY donors to rhodamine and merocyanine acceptors for ratiometric determination of lysosomal pH variations. Probe A consists of a 1,3,5,7-tetramethyl-BODIPY dono...
Label-Free Pathogen Detection by a Deoxyribozyme Cascade with Visual Signal Readout [0.03%]
基于脱氧核酶级联反应的视窗报告型病原体检测新方法
Adam J Reed,Ryan P Connelly,Allison Williams et al.
Adam J Reed et al.
A colorimetric nucleic acid based test for label-free pathogen detection has been developed and used for the detection of the Zika virus. The test relies on nucleic acid sequence-based amplification (NASBA) of a viral RNA followed by interr...
Bradley Ledden,Joe Bruton Jr
Bradley Ledden
We developed a ring electrode sensor for down-stream electrochemical sensing of microfluidic ELISA assay. The sensor is designed to easily integrate into the flow environment. Noble metal inks on Low Temperature Co-fired Ceramic provide str...