A Quinolinium-Functionalized Hemicyanine Dye for Ratiometric NAD(P)H Sensing in Live Cells, Kidney Tissues, and Drosophila melanogaster [0.03%]
一种用于活细胞、肾组织和果蝇中比值型NAD(P)H荧光成像的茋类双染料
Sushil K Dwivedi,Henry Lanquaye,May Waters et al.
Sushil K Dwivedi et al.
NAD+ (Nicotinamide adenine dinucleotide) and NADP+ (its phosphorylated variation) are key coenzymes regulating cellular metabolism, biosynthesis, and redox balance. Variations in NAD(P)H activity reflect metabolic activity and are associate...
Huilu Bao,Xiao Fan,Xiaoyu Zhang et al.
Huilu Bao et al.
Measuring sodium ion concentration in breast milk can provide crucial health information for both mother and infant, including early signs of low-grade infection and reduced milk supply. Traditional sensing methods are slow, bulky, expensiv...
Activatable near-infrared fluorescence and chemical exchange saturation transfer MRI multimodal imaging probe for tumor detection in vitro and in vivo [0.03%]
用于体内外肿瘤检测的可激活近红外荧光和化学交换饱和转移磁共振双模成像探测剂
Sanu Karan,Jee-Hyun Cho,Chau Thi Ngoc Tran et al.
Sanu Karan et al.
Multimodal imaging has emerged as a powerful tool in biomedical research and clinical diagnostics. Ideally, it combines multiple imaging techniques to provide complementary anatomical and molecular information in living subjects. Particular...
Gold Nanoprism Enhanced SERS Aptasensor for Simultaneous Detection of Thrombin and VEGF [0.03%]
金纳米棱镜增强的SERS适配子传感器同时检测血栓素和VEGF
Pooja Anantha,Piyush Raj,Peng Zheng et al.
Pooja Anantha et al.
Sensitive detection of disease-specific biomarkers with high accuracy is crucial for early diagnosis, therapeutic monitoring, and understanding underlying pathological mechanisms. Traditional methods, such as immunohistochemistry and enzyme...
A Single Microfluidic Device Approach to Direct Isolation, Purification, and Amplification of cfDNA from Undiluted Plasma [0.03%]
一种直接从未经稀释的血浆中分离、纯化和扩增循环DNA的微流体装置方法
Sean Hamilton,Sara Evans-Dutson,Jose Luis Montoya Mira et al.
Sean Hamilton et al.
Circulating cell free DNA (cfDNA) is a valuable source of biomarkers for a range of medical applications including detection and monitoring of diseases. Currently, cfDNA sequence analysis must take place in a laboratory setting, due to the ...
3-Dimensional electrical impedance spectroscopy for in situ endoluminal mapping of metabolically active plaques [0.03%]
三维电阻抗谱成像技术在代谢性易损斑块检测中的应用
Parinaz Abiri,Yuan Luo,Zi-Yu Huang et al.
Parinaz Abiri et al.
Electrical impedance spectroscopy (EIS) has been recognized to characterize oxidized low-density lipoprotein (oxLDL) in the metabolically active plaque. However, intravascular deployment of 3-D EIS-derived electrical impedance tomography (E...
David J Boegner,John R Rzasa,Evan H Benke et al.
David J Boegner et al.
Highly accessible and highly accurate diagnostics are necessary to combat rapidly-spreading infectious diseases, such as the recent COVID-19 pandemic. While lateral flow antigen tests have become pervasive, they are insufficiently sensitive...
Ty Naquin,Shivam Jain,Jinxin Zhang et al.
Ty Naquin et al.
Droplet microfluidics has emerged as a valuable technology for a multitude of chemical and biomedical applications, offering the capability to create independent microenvironments for high-throughput assays. Central to numerous droplet micr...
Manually-Operated, Slider Cassette for Multiplexed Molecular Detection at the Point of Care [0.03%]
一种用于护理点多重分子检测的手动滑板式盒装装置
Youngung Seok,Qingtian Yin,Ruijie Li et al.
Youngung Seok et al.
Effective control of epidemics, individualized medicine, and new drugs with virologic response-dependent dose and timing require, among other things, simple, inexpensive, multiplexed molecular detection platforms suitable for point of care ...
Near-infrared Absorption and Emission Probes with Optimal Connection Bridges for Live Monitoring of NAD(P)H Dynamics in Living Systems [0.03%]
具有最佳连接桥的近红外吸收和发射探针用于活细胞内监测烟酰胺腺嘌呤二核苷酸（磷酸）的动力学变化
Sushil K Dwivedi,Dilka Liyana Arachchige,May Waters et al.
Sushil K Dwivedi et al.
Two NAD(P)H-biosensing probes consisting of 1,3,3-trimethyl-3H-indolium and 3-quinolinium acceptors, linked by thiophene, A, and 3,4-ethylenedioxythiophene, B, bridges are detailed. We synthesized probes C and D, replacing the thiophene con...