MIR99AHG alleviates reflux esophagitis caused by gastroesophageal reflux disease by downregulating miR-200a-3p [0.03%]
Jincai Chen,Qianli Liu,Xiaowen Zheng et al.
Jincai Chen et al.
Reflux esophagitis (RE) can progress to severe complications if not diagnosed and treated promptly. MIR99AHG is downregulated in the precursor disease of RE. This study aims to investigate the expression and regulatory mechanisms of MIR99AH...
Naping Wu,Xiaozhou He
Naping Wu
The fat mass and obesity-associated protein (FTO), an N6-methyladenosine (m6A) demethylase, plays a crucial role in various cancers. This study investigates its expression and functional role in bladder cancer (BCa). Analysis of TCGA data a...
Exploring the laxative effects of emodin on constipation through chloride channel activation [0.03%]
Shan-Shan Han,Qiang Chen,Li-Sheng Huo et al.
Shan-Shan Han et al.
Constipation, a prevalent gastrointestinal disorder, significantly impairs quality of life. Emodin, a bioactive anthraquinone found in traditional herbal remedies like Rheum palmatum, is empirically known for its laxative effects, yet its p...
Resveratrol coordinates apoptosis and autophagy in hepatocellular carcinoma cells via p53 acetylation: An integrative network pharmacology and experimental validation study [0.03%]
Hui Zhang,Huidong Zhang,Wei Li et al.
Hui Zhang et al.
Hepatocellular carcinoma (HCC) remains a therapeutic challenge due to late-stage diagnosis and suboptimal response to standard therapies. Resveratrol, a plant-derived polyphenol, suppresses proliferation of HCC cells by inducing apoptosis a...
Liquid-liquid phase separation of TRIM21 regulates EZH2-mediated ferroptosis to facilitate hepatocellular carcinoma progression [0.03%]
Li Xu,Shilun Wu,Changyu Yao et al.
Li Xu et al.
Background Liquid-liquid phase separation (LLPS) has emerged as an important regulatory mechanism in cancer biology and has been implicated in hepatocellular carcinoma (HCC) progression. LLPS has also been linked to ferroptosis, a regulated...
Skin-whitening, antioxidant, and anti-inflammatory effects of Angelica decursiva ethanol extract [0.03%]
Angelica decursiva乙醇提取物的美白抗氧化抗炎作用研究
Jusuk Hwang,Si Eun Yoon,Sohee Moon et al.
Jusuk Hwang et al.
The multifunctional potential of Angelica decursiva ethanol extract (Ad-EE) was evaluated to address the safety and efficacy limitations of conventional whitening agents. Experimental results indicate that Ad-EE suppresses melanin secretion...
Lysine-proline-valine peptide attenuates hepatic lipid accumulation through ROS-dependent regulation of the PPARγ pathway in HepG2 cells [0.03%]
天冬氨酸-脯氨酸-缬氨酸三肽通过依赖于ROS的PPARγ通路调节作用抑制肝细胞脂质蓄积
Ju-Yeon Lee,Jin Lee,Won-Kyo Jung et al.
Ju-Yeon Lee et al.
Hepatocellular steatosis, an early stage within the non-alcoholic fatty liver disease (NAFLD) spectrum, is characterized by excessive lipid accumulation and oxidative stress in hepatocytes. This study examined the protective role of Lysine-...
Repair of rat skin defects using decellularized skin matrix/chitosan hybrid hydrogels [0.03%]
脱细胞皮肤基质/壳聚糖杂化水凝胶修复大鼠皮肤缺损
Chen Wu,Yunjie Wang,Chao Ci et al.
Chen Wu et al.
Full-thickness skin wounds pose a substantial clinical challenge and burden in the medical field. Currently, skin tissue engineering is a promising approach with broad potential applications in the treatment of skin defects. Decellularized ...
m6A-modified circFOXA1 promotes tumor immune evasion via enhancing PD-L1 deubiquitination in triple-negative breast cancer [0.03%]
circFOXA1通过促进PD-L1去泛素化在三阴性乳腺癌中促进肿瘤免疫逃逸
Honghong Shen,Boyu Li,Xiaoqian Wen et al.
Honghong Shen et al.
Restoring CD8⁺T cell infiltration and potentiating anti-tumor immune responses in the tumor microenvironment (TME) is critical for developing effective immunotherapies against triple-negative breast cancer(TNBC), while the regulatory role ...
TM4SF1 regulates esophageal squamous cell carcinoma KYSE150 cell phenotypes via miRNA-regulated pathways [0.03%]
TM4SF1通过miRNA调节通路调控食管鳞癌KYSE150细胞表型
Annatasha Stephen,Yuan Seng Wu,Nur Syafiqah Rahim et al.
Annatasha Stephen et al.
TM4SF1, a small transmembrane glycoprotein, has been implicated in tumor progression across multiple cancers. However, its functional and regulatory roles in esophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), remain ...