Gamma-terpinene suppresses the growth of lymphoblastic cancerous cells in vitro , possibly via multiple proposed molecular mechanisms, including apoptosis and gene expression modulation [0.03%]
γ萜品烯通过多种分子机制抑制淋巴母细胞癌细胞的增殖
Pooya Baradaran Safa,Maryam Nooshadokht,Maryam Mohit et al.
Pooya Baradaran Safa et al.
ALL is recognised as a heterogeneous malignancy affecting lymphocyte precursors. Considering shortcomings of the current treatments, herbal compounds have always been in the focus of attention as novel anticancer candidates, owing to their ...
USP5 inhibits osteogenic differentiation but promotes oxidative stress and M1-like macrophage polarization of human periodontal ligament stem cells via deubiquitinating and stabilizing RIPK1: insights from in vitro and in vivo analyses [0.03%]
USP5通过去泛素化和稳定RIPK1来抑制人牙周膜干细胞成骨分化但促进氧化应激及M1型巨噬细胞极化：来自体内外实验的证据
Jinghong Mao,Ming Qin
Jinghong Mao
Chronic periodontitis (CP) is a chronic infectious disease. Ubiquitin-specific protease 5 (USP5), a member of the deubiquitinase family, has garnered significant attention due to its crucial biological functions. In this study, we aimed to ...
Combination of paclitaxel with eugenol effectively enhances anticancer characteristics of paclitaxel on the A549 lung cancer cell line [0.03%]
肉桂酚联合紫杉醇对A549肺癌细胞系的抗癌特性研究显示两者结合可以有效增强紫杉醇的抗癌性能
Hazim Dhaidan Malghooth Almalghooth,Mohammad Khalaj-Kondori,Mohammad Ali Hosseinpour Feizi
Hazim Dhaidan Malghooth Almalghooth
Lung cancer, primarily non-small cell lung cancer (NSCLC), is a leading global cause of cancer mortality, driven by late diagnosis, drug resistance, and chemotherapy toxicity. Paclitaxel, a standard agent, stabilizes microtubules to induce ...
RBM15 enhances ILDR1 n6-methyladenosine methylation to accelerate gastric adenocarcinoma progression via an IGF2BP3-dependent manner [0.03%]
RBM15通过IGF2BP3依赖性方式增强ILDRI n6-甲基腺苷甲基化以加速胃腺癌进展
Wei Hu,Xin Zhou,Bin Jiang et al.
Wei Hu et al.
Gastric adenocarcinoma (GA), a major contributor to cancer-related mortality worldwide, is characterized by malignant progression driven by complex gene regulatory networks. However, the biological functions and N6-methyladenosine (m6A)-dep...
Apigenin attenuates hepatocyte senescence in metabolic dysfunction-associated steatotic liver disease by targeting the TGF-β signaling pathway [0.03%]
染料木素通过靶向TGF-β信号通路抑制代谢功能障碍相关脂肪性肝病的肝细胞衰老
Lijun Cao,Yongna Zhao
Lijun Cao
This study aimed to investigate whether the natural flavonoid apigenin attenuates hepatocyte senescence and ameliorates high-fat diet (HFD)-induced metabolic dysfunction-associated steatotic liver disease (MASLD) by inhibiting the transform...
Iodine-125 seed induces ferroptosis through inhibiting RNF216-mediated ubiquitination of p53 in cholangiocarcinoma cells [0.03%]
~125I粒子通过抑制RNF216介导的p53泛素化在胆管癌细胞中诱导铁死亡
Jing Wu,Xiaoning Chang,Jianjun Song et al.
Jing Wu et al.
Iodine-125 (125I) seed has effectively treated cholangiocarcinoma (CCA) in previous research. Ferroptosis, a new form of programmed cell death, is linked to cancers including CCA. However, the relationship between 125I seed and ferroptosis ...
Magnetic resonance imaging-based Alzheimer's disease detection using an EfficientNet-CMSACCN framework [0.03%]
基于磁共振成像的阿尔茨海默病检测的EfficientNet-CMSACCN框架
S Sujanthi,A M Ravishankkar,S Ponmaniraj et al.
S Sujanthi et al.
Alzheimer's Disease (AD) is a degenerative neurological condition characterized by memory loss, cognitive deterioration, and brain tissue shrinkage. Detecting it at an early stage is difficult due to variations in disease progression and th...
Brusatol Induces Ferroptosis in Condyloma Acuminatum Keratinocytes by Suppressing Nrf2 via Inhibition of the PI3K/AKT Pathway [0.03%]
布拉苏坦通过抑制PI3K/AKT通路抑制Nrf2诱导尖锐湿疣角质形成细胞铁死亡
WeiQi Wu,Juan Yang,XiuYi Lu et al.
WeiQi Wu et al.
Objective Condyloma acuminatum (CA), a common sexually transmitted disease caused by human papillomavirus (HPV) infection, is closely associated with the abnormal proliferation and differentiation of host keratinocytes. Brusatol (BRU), a qu...
The inhibitory effect of curcumin on airway inflammation in mice with chronic obstructive pulmonary disease and its mechanism: a study based on the PPARγ/AMPK/mTORC1 pathway [0.03%]
姜黄素对慢性阻塞性肺疾病小鼠气道炎症的抑制作用及其机制：基于PPARγ/AMPK/mTORC1通路的研究
Mengjuan Wang,Kaifeng Zhang,Yujia Zhang et al.
Mengjuan Wang et al.
In this article, we explored the mechanism of curcumin (CUR) in mitigating airway inflammation in a mouse model of chronic obstructive pulmonary disease (COPD) based on the peroxisome proliferator-activated receptor γ (PPARγ)/adenosine mo...
Based on comprehensive analysis of ScRNA-seq and bulk RNA-seq, identification of palmitoylation-related genes as biomarkers to evaluate prognosis and immune landscape in stomach adenocarcinoma [0.03%]
基于scRNA-seq和bulk RNA-seq的综合分析，识别棕榈酰化相关基因作为评估胃腺癌预后和免疫景观的生物标志物
Zeren Leng,Wenzhe Zhang
Zeren Leng
Stomach adenocarcinoma (STAD) poses a significant global health burden, with notable geographic variations in its incidence and complex underlying causes. Palmitoylation plays a crucial role in cancer development, yet its prognostic relevan...