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Expression and clinical significance of IGF-1 and PDGF in aqueous humor and serum of diabetic patients with visually significant cataract [0.03%] 糖尿病合并视功能影响的白内障患者房水及血液中IGF-1和PDGF表达及其临床意义
Minghui Chen,Xiuwen Dai,Jing Liang Minghui Chen
This study aimed to analyze the expression and clinical significance of IGF-1 and PDGF in the aqueous humor and serum of diabetic patients with visually significant cataract. A retrospective study was conducted on 136 diabetic patients with...
Anti-cancer efficiency of Campylobacter jejuni secretome loaded chitosan nanoparticles on colorectal cancer signaling pathways [0.03%] 一种新型鸡甘蓝-secretome载壳聚糖纳米颗粒抗结直肠癌信号通路效力研究
Ghazale Khodadadi,Masoumeh Saberpour,Bita Bakhshi et al. Ghazale Khodadadi et al.
Colorectal cancer (CRC) remains as a major health problem with high lethality rate in the world. The innovate therapeutic strategies are essential in CRC management. The purpose of this research was to evaluate the effect of chitosan nanopa...
PRELP regulated by GAS5/miR-3127-5p suppresses cisplatin resistance in oral squamous cell carcinoma [0.03%] GAS5/miR-3127-5p调节的PRELP抑制口腔鳞癌顺铂耐药性
Xiaoni Sun,Yang Liu,Luyi Chai et al. Xiaoni Sun et al.
Our previous study has identified that PRELP inhibits the progression of oral squamous cell carcinoma (OSCC). This study aimed to investigate the influence of PRELP on cisplatin (DDP) resistance in OSCC cells and to elucidate the underlying...
Correction: Proanthocyanidin B2 alleviates Pg.LPS-induced RAW264.7 cellular inflammation and oxidative stress via PI3K/Akt/NFkB pathway [0.03%] 校正：原花青素B₂通过PI3K/Akt/NF-κB途径缓解Pg.LPS诱导的RAW264.7细胞炎症和氧化应激
Xin Chen,Zhichun Fang,Junwei Zhao et al. Xin Chen et al.
[This corrects the article DOI: 10.1007/s10616-025-00734-6.]. © The Author(s), under exclusive licence to Springer Nature B.V. 2025.
New mechanism of miR-34a-5p in regulating the biological behavior of osteosarcoma by targeting FoxM1 [0.03%] miR-34a-5p通过靶向FoxM1调控骨肉瘤生物学行为的新机制研究
Wenxiang Shen,Xiang Liu,Shengdong Wang et al. Wenxiang Shen et al.
Osteosarcoma (OS), the most common primary malignant bone tumor in pediatric and adolescent populations, is characterized by significant morbidity and mortality. MicroRNAs (miRNAs) are essential non-coding RNAs that exert pivotal regulatory...
LncRNA SNHG25 facilitates colorectal cancer progression by upregulating PPP2R2D expression through sponging miR-329-3p [0.03%] 长链非编码RNA SNHG25通过吸附miR-329-3p上调PPP2R2D表达促进结直肠癌进展
Yuanqiang Li,Weipeng Liu,Chao Liu et al. Yuanqiang Li et al.
Long non-coding RNAs (lncRNAs) have been evidenced to function as pivotal modulators in tumorigenesis. LncRNA SNHG25 is highly expressed in colorectal cancer (CRC), but its specific function in CRC has not been elucidated yet. The expressio...
Exosomes derived from human umbilical cord blood mesenchymal stem cells protect against blue light-induced damage to retinal pigment epithelial cells by inhibiting FGF2 expression [0.03%] 人脐带间充质干细胞来源的外泌体通过抑制FGF2表达保护视网膜色素上皮细胞免受蓝光损伤
Guang-Ming Liu,Yan Liu Guang-Ming Liu
Age-related macular degeneration (AMD) is a debilitating retinal disorder that may lead to progressive vision loss. One contributing factor to AMD pathogenesis is excessive blue light (BL) exposure. In this study, we investigated the therap...
cPLA2α on the influence of Th17 and its role in the formation of liver fibrosis [0.03%] cPLA2α对Th17的影响及其在肝纤维化形成中的作用研究
Lina Ma,Wei Wang,Limin Gu et al. Lina Ma et al.
This study primarily investigated the mechanism and pathways of the cPLA2α signaling pathway on Th17-mediated HSC activation and liver fibrosis, providing insights for clinical strategies to target HSC activation and delay the rapid progre...
Metformin inhibits subretinal fibrosis by activating Klotho by miR-126-5p [0.03%] miR-126-5p通过激活Klotho抑制代谢物甲福明诱导的视网膜下纤维化
Zhijuan Hua,Qin Zhu,Jingfei Yang et al. Zhijuan Hua et al.
Subretinal fibrosis is a main cause of visual loss in patients with neovascular age-related macular degeneration (nAMD), for whom there has been a lack of effective medication. Metformin can improve inflammation and angiogenesis in eye dise...
Mahsa Golshan,Hengameh Dortaj,Zeinab Omidi et al. Mahsa Golshan et al.
Platelet-rich plasma (PRP) has emerged as a promising biological therapy in regenerative medicine due to its high concentration of growth factors and cytokines, which promote tissue healing and regeneration. In recent years, its application...