Hydroalcoholic seed extract of Abelmoschus moschatus attenuates complete freund's adjuvant-induced arthritis in wistar rats: an in vivo pharmacological study [0.03%]
愈伤木香种子的水醇提取物对大鼠完全弗氏佐剂诱导性关节炎的抑制作用：体内药理学研究
Jitu Pawar,Tanvi H Desai,Vipul G Gajera et al.
Jitu Pawar et al.
Abelmoschus moschatus i.a. a prostrate herb that is grown for its seed in tropical portions of Africa, South America, and Asia. It is a member of the Malvaceae family and also referred to Mushkdana. This plant has been reported for diuretic...
SOX4 facilitates osteogenic differentiation through suppressing NLRP3 transcription-mediated pyroptosis [0.03%]
SOX4通过抑制NLRP3转录介导的细胞焦亡促进成骨分化
Ping Li,Xue-Yi Lin,Yu Lin et al.
Ping Li et al.
SOX4 participates in cell differentiation, but its regulatory function and underlying mechanism in the osteogenic differentiation of MC3T3-E1 cells remain elusive. Immunofluorescence staining was used to detect SOX4 subcellular localization...
TRIM39 suppresses endometrioid endometrial carcinoma progression via ubiquitination and degradation of HOXB9 [0.03%]
TRIM39通过泛素化和降解HOXB9抑制子宫内膜样子宫内膜癌的进展
Fei Zheng,Shuya Han,Hongqing Gu et al.
Fei Zheng et al.
Endometrioid endometrial carcinoma (EEC) is the major histological type of endometrial cancer, the most common gynecological malignancies in the world, and its incidence and mortality continue to increase. However, the molecular mechanism o...
Apoptosis induction by polyphenolic-rich extracts from Flourensia cernua and Flourensia retinophylla in human colon adenocarcinoma cells [0.03%]
弗洛伦西亚植物多酚诱导人结肠腺癌细胞凋亡的作用机制研究
Diana Jasso de Rodríguez,Dennise Anahí Carrillo-Lomelí,J Omar Díaz-Rivas et al.
Diana Jasso de Rodríguez et al.
Colorectal cancer remains a leading cause of cancer-related death, and there is an urgent need for new therapies that can specifically induce tumor cell apoptosis. Plant polyphenols have emerged as promising alternatives for cancer treatmen...
MGRN1 alleviates the progression of obesity-related acute lung injury by protecting lung epithelial cells through restoring mitochondrial function [0.03%]
MGRN1通过恢复线粒体功能保护肺上皮细胞从而缓解肥胖相关急性肺损伤进展
Yingping Wang,Liming Lu,Hui Jin et al.
Yingping Wang et al.
Acute lung injury (ALI) is a common respiratory disease worldwide, and obesity is a significant factor contributing to its progression. However, there is still a lack of effective clinical interventions specifically targeting this condition...
Stichopus japonicus acidic mucopolysaccharide (SJAMP) exerts the tumor-suppressive activity in cervical cancer by targeting TFAP2A to downregulate CENPW [0.03%]
弹吉拉海参酸性粘多糖通过靶向TFAP2A下调CENPW发挥抗宫颈癌作用
Zhengxiang Cai,Dachun Liu,Yongpeng He et al.
Zhengxiang Cai et al.
Cervical cancer (CC) remains a leading cause of cancer-related mortality among women, and advances in its therapeutic approaches are disappointing, in which novel therapies and precise experimental approaches are needed to be exploited. Thi...
WGCNA-based identification and experimental validation of TOP2A as a key regulator of ferroptosis in sepsis-associated acute respiratory distress syndrome [0.03%]
基于WGCNA的鉴定和实验验证TOP2A作为脓毒症相关急性呼吸窘迫综合征铁死亡的关键调节因子
Na Wang,Kang Li,Chuanyong Gong et al.
Na Wang et al.
Sepsis-associated acute respiratory distress syndrome (SA-ARDS) is a severe disease with high morbidity and mortality. Emerging evidence indicates that ferroptosis plays a critical role in the development of SA-ARDS. However, the key regula...
Cancer-associated fibroblast-derived CCL11 promotes prostate cancer malignancy by inducing epithelial-mesenchymal transition via CDK5 [0.03%]
癌相关成纤维细胞衍生的CCL11通过CDK5诱导上皮间质转化从而促进前列腺癌恶性进展
Yu Wu,Xingyu Chen,Xinwei Yuan et al.
Yu Wu et al.
To elucidate the key role and underlying mechanisms of C-C motif chemokine ligand 11 (CCL11) in cancer-associated fibroblasts (CAFs)-mediated prostate cancer (PCa) progression. In this study, we analyzed the dataset GSE85606 and validated t...
Anticancer potential of Viola cornuta-derived green-synthesized CuO nanoparticles via ROS-induced apoptosis in breast cancer cell lines [0.03%]
一种通过ROS诱导的细胞凋亡作用于乳腺癌细胞系的抗癌活性——来自Viola cornuta绿色合成的CuO纳米粒子的作用潜力
Maryam Fekri Soufiabadi,Mahsa Ziasistani,Hannaneh Bazgir et al.
Maryam Fekri Soufiabadi et al.
Breast cancer is associated with significant mortality amongst women universally. Common treatments face various difficulties, including the development of drug resistance. This fact necessitates the exploration of new therapeutic protocols...
Artesunate promotes liver regeneration by modulating mitophagy via the AMPKα1/2/mTOR signaling pathway [0.03%]
艺术类药物通过调节线粒体自噬促进肝脏再生的作用及机制研究
Xinkai Li,Chuntao Li,Chao Fang et al.
Xinkai Li et al.
Partial hepatectomy (PH) triggers acute liver insufficiency and a tightly-orchestrated regenerative program. Here we show that artesunate (ART) markedly accelerates liver mass restoration in mice subjected to PH. ART elevated the liver inde...