Drug review process advancement and required manufacturer and contract research oraganization responses [0.03%]
药物审评流程进展及对申办方和合同研究组织的要求响应
Takayuki Anzai,Glenn J Myatt,Frances Hall et al.
Takayuki Anzai et al.
The United States Senate passed the "FDA Modernization Act 2.0." on September 29, 2022. Although the effectiveness of this Bill, which aims to eliminate the mandatory use of laboratory animals in new drug development, is limited, it represe...
Induction of lung lesions by bronchial administration using bronchoscope technique in mice [0.03%]
支气管镜技术介导的气道内给药诱导小鼠肺部病变模型的研究
Takako Hiyoshi,Chiyoko Nishime,Eiko Nishinaka et al.
Takako Hiyoshi et al.
This study aimed to establish an exposure method that can induce homogeneous lesions with minimal inter-individual variability. The distribution of lesions induced by bleomycin (BLM) administration was also analyzed. C57BL mice were intrabr...
CD44 expression in renal tubular epithelial cells in the kidneys of rats with cyclosporine-induced chronic kidney disease [0.03%]
环孢素致慢性肾脏病大鼠肾小管上皮细胞CD44表达
Kohei Matsushita,Takeshi Toyoda,Hirotoshi Akane et al.
Kohei Matsushita et al.
Renal tubular epithelial cell (TEC) injury is the most common cause of drug-induced kidney injury (DIKI). Although TEC regeneration facilitates renal function and structural recovery following DIKI, maladaptive repair of TECs leads to irrev...
Neural tissue tolerance to synthetic dural mater graft implantation in a rabbit durotomy model [0.03%]
一种合成硬脑膜移植物在兔硬脑膜切开模型中的神经耐受研究
Yuval Ramot,Noam Kronfeld,Michal Steiner et al.
Yuval Ramot et al.
In neurosurgical interventions, effective closure of the dura mater is essential to prevent cerebrospinal fluid leakage and minimize post-operative complications. Biodegradable synthetic materials have the potential to be used as dura mater...
Lobular distribution of enhanced expression levels of heat shock proteins using in-situ hybridization in the mouse liver treated with a single administration of CCl4 [0.03%]
单次CCl4处理的小鼠肝脏中热休克蛋白表达水平增强的原位杂交定位分布研究
Hitoshi Kandori,Masami Aoki,Yumiko Miyamoto et al.
Hitoshi Kandori et al.
This study was conducted to visualize the lobular distribution of enhanced mRNA expression levels of heat shock proteins (HSPs) in liver samples from carbon tetra chloride (CCl4)-treated mice using in-situ hybridization (ISH). Male BALB/c m...
Takuma Yamamoto,Yuko Emoto,Takehiko Murase et al.
Takuma Yamamoto et al.
Japan has various death investigation systems; however, external examinations, postmortem computed tomography, macroscopic examinations, and microscopic examinations are performed regardless of the system used. These examinations can reveal...
Spontaneous mandibular follicular ameloblastoma in a female Sprague-Dawley rat [0.03%]
雌性斯普拉格-道利(Sprague-Dawley)大鼠下颌自发成釉细胞瘤病变
Juan Li,Guojian Jiang,Jie Zhang et al.
Juan Li et al.
Ameloblastoma is a locally aggressive tumor derived from the odontogenic epithelium of the developing tooth germ. It is rarely reported in experimental Sprague-Dawley (SD) rats. In this 90-day percutaneous repeated-dose toxicity study, mand...
Pathogenesis of chemically induced nasal cavity tumors in rodents: contribution to adverse outcome pathway [0.03%]
化学诱导啮齿动物鼻腔肿瘤的发病机理：对不利结局通道的贡献
Akiyoshi Nishikawa,Kasuke Nagano,Hajime Kojima et al.
Akiyoshi Nishikawa et al.
The pathogenesis of nasal cavity tumors induced in rodents has been critically reviewed. Chemical substances that induce nasal cavity tumors in rats, mice, and hamsters were searched in the National Toxicology Program (NTP), International A...
Identifying the dataset to define the optimal timing of histopathological examination for central nervous system toxicity in MPTP-induced Parkinson's disease monkey model [0.03%]
识别数据集以定义MPTP诱导的帕金森病猴模型中枢神经系统毒性的最佳病理检查时间点
Hironobu Yasuno,Yasushi Masuda,Harushige Ozaki et al.
Hironobu Yasuno et al.
Determining the optimal timing for histopathological examination following exposure to a test article is crucial for assessing neurotoxicity. However, no study has focused on identifying an ideal dataset to define the optimal timing for his...
Smooth muscle hamartoma of the lungs in a Wistar Hannover rat [0.03%]
郑宫氏平滑肌错构瘤的肺部病变一窝汉诺威Wistar大鼠发生案
Shinya Miyazaki,Chinatsu Fujiwara,Yoshitaka Katoh et al.
Shinya Miyazaki et al.
Hamartomas are tumor-like masses comprising disorganized normal tissue elements. To date, spontaneous hamartomas have been reported in several organs and tissues in rodents but not in the lungs. Here, we report the first case of a hamartoma...