Safety and efficacy of a novel robotic, fractional micro-coring device in a swine model [0.03%]
猪模型中新型机器人分段微穿孔设备的安全性和有效性研究
Yuval Ramot,Udi Vazana,Orna Cacical et al.
Yuval Ramot et al.
Laser resurfacing may be accompanied by unwanted side effects. The micro coring technology, designed to remove small skin columns, was developed to avoid the thermal injury associated with lasers. However, very limited data are available on...
Gene expression analysis of antioxidant and DNA methylation on the rat liver after 4-week wood preservative chromated copper arsenate exposure [0.03%]
木 preservation铬铜砷处理染毒大鼠肝脏抗氧化及DNA甲基化基因表达分析
Naofumi Takahashi,Satoru Yamaguchi,Ryouichi Ohtsuka et al.
Naofumi Takahashi et al.
Our previous 4-week repeated dose toxicity study showed that wood preservative chromated copper arsenate (CCA) induced hepatocellular hypertrophy accompanied by biochemical hepatic dysfunction and an increase in oxidative stress marker, 8-h...
Application of convolutional neural network for analyzing hepatic fibrosis in mice [0.03%]
卷积神经网络在小鼠肝纤维化分析中的应用
Hyun-Ji Kim,Eun Bok Baek,Ji-Hee Hwang et al.
Hyun-Ji Kim et al.
Recently, with the development of computer vision using artificial intelligence (AI), clinical research on diagnosis and prediction using medical image data has increased. In this study, we applied AI methods to analyze hepatic fibrosis in ...
Two cases of cartilaginous metaplasia in the sclera of Japanese White rabbits [0.03%]
日本大耳白兔角膜基质两例软骨化生报道
Kotaro Yamada,Yoshinori Yamagiwa,Miki Masatsugu et al.
Kotaro Yamada et al.
Spontaneous cartilaginous metaplasia of the sclera has not been reported in rabbits. Herein, we report two cases of spontaneous cartilaginous metaplasia in the sclera of Japanese White (JW) rabbits. Case 1 was noted in a 14-week-old male Kb...
Effects of Siraitia grosvenorii extract on nonalcoholic steatohepatitis-like lesions in Sprague Dawley rats fed a choline-deficient, methionine-lowered, l-amino acid-defined diet [0.03%]
Siraitia grosvenorii提取物对喂食定量l-氨基酸、低胆碱和蛋氨酸饲料的大鼠的非酒精性脂肪肝病变的影响
Kinuko Uno,Katsuhiro Miyajima,Shuji Ogawa et al.
Kinuko Uno et al.
Siraitia grosvenorii is the fruit of a cucurbitaceous vine endemic to China. Its extract has been used as a sweetener and exhibits various anti-inflammatory and anticarcinogenic effects mediated via its antioxidant properties. In the presen...
Kyohei Yasuno,Masako Imaoka,Tetsuya Ohsawa et al.
Kyohei Yasuno et al.
Inflammation of the cardiac coronary artery in ICR mice is occasionally observed in toxicity studies; however, this has not been well explored histologically. Herein, we investigated the detailed histology of the associated lesions in 6-8-w...
Lack of hepatocarcinogenicity of 2,2'-[1,2-ethanediylbis(oxymethylene)]bis-oxirane, 3-hydroxy-2-naphthoic acid, and acetoacetanilide in a medium-term rat liver bioassay [0.03%]
中期内在大鼠肝脏生物测定中2,2'-[1,2-亚乙基双(氧甲基)]双氧化环烷、3-羟基-2-萘酸和乙酰乙酸酐无致肝癌作用
Hiroshi Yamagata,Tsubasa Saito,Takezo Okamoto et al.
Hiroshi Yamagata et al.
The carcinogenicity of 2,2'-[1,2-ethanediylbis(oxymethylene)]bis-oxirane (ethylene glycol diglycidyl ether; EGDE), 3-hydroxy-2-naphthoic acid (HNA), and acetoacetanilide (AAA) was investigated using a medium-term rat liver bioassay for an o...
Kidney organoid derived from renal tissue stem cells is a useful tool for histopathological assessment of nephrotoxicity in a cisplatin-induced acute renal tubular injury model [0.03%]
由肾组织干细胞衍生的类肾器官是评估顺铂诱导急性肾小管损伤模型中的肾毒性的组织病理学检测的有效工具
Shota Ueno,Kenji Kokura,Yasushi Kuromi et al.
Shota Ueno et al.
Organoids derived from renal tissue stem cells (KS cells) isolated from the S3 segment of adult rat nephrons have previously been developed and evaluated. However, data regarding the histopathological evaluation of these organoids are limit...
Early detection of urinary bladder carcinogens in rats by immunohistochemistry for γ-H2AX: a review from analyses of 100 chemicals [0.03%]
利用γ-H2AX免疫组织化学早期检测大鼠膀胱致癌物：对100种化学物质分析的综述
Takeshi Toyoda,Kumiko Ogawa
Takeshi Toyoda
In safety evaluations of chemicals, there is an urgent need to develop short-term methods to replace long-term carcinogenicity tests. We have reported that immunohistochemistry for γ-H2AX, a well-established biomarker of DNA damage, can de...