Influence of rapamycin and chloroquine on chemically-induced liver injury in rats [0.03%]
雷帕霉素和氯喹对化学因素致大鼠肝损伤的影响
Sho Fujiwara,Takeshi Izawa,Mutsuki Mori et al.
Sho Fujiwara et al.
Drug-induced liver injury is a major reason for the discontinuation of drug development. Autophagy is a self-digestive process in the cell and can suppress cell death by removing damaged organelle from the cell. It is known that autophagy c...
Association between spontaneous neurogenic atrophy of the femoral muscle and islet cell tumors in aged F344 rats [0.03%]
老龄F344大鼠股外肌神经源性萎缩与胰岛细胞肿瘤的关联性研究
Mitsutoshi Uchida,Yumi Wako,Takeshi Kanno et al.
Mitsutoshi Uchida et al.
In aged F344/DuCrlCrlj rats, we observed that all animals with group atrophy of the biceps femoris muscle also had islet cell tumors, suggesting that spontaneous islet cell tumors may induce peripheral neuropathy and muscle atrophy. Among 2...
Evaluation of tumor clonality with chemical carcinogenesis in a mouse model of visualized X chromosome inactivation [0.03%]
视觉X染色体失活小鼠模型中化学致癌的肿瘤克隆性评价
Tomomi Maeda-Tateishi,Yuki Nagata,Yasuo Imanishi et al.
Tomomi Maeda-Tateishi et al.
Tumor clonality is determined by somatic mutations in genes that regulate cell proliferation, and this can be either monoclonal or multiclonal. Assays based on X-chromosome inactivation that exploit the random inactivation of one of the two...
A canine insulinoma with amphicrine differentiation: morphological and immunohistochemical characteristics [0.03%]
具有双分化的犬胰岛细胞瘤的形态和免疫组化特征
Hisaki Tokuno,Masashi Fujimoto,Makoto Tsuji et al.
Hisaki Tokuno et al.
A 10-year-old male toy poodle presented with hypoglycemia. An insulinoma was suspected and a surgical excision of two pancreatic masses was performed. White-gray, demarcated, soft masses were identified in the pancreas. Histopathologically,...
Intramuscular collagen accumulation in different types of skeletal muscle fibers in middle-aged male rats [0.03%]
中年雄性大鼠不同类型骨骼肌纤维内肌肉沉积的研究
Yoshikazu Taketa,Hideaki Takahashi
Yoshikazu Taketa
This study focused on the histological characterization of age-related intramuscular collagen accumulation in different skeletal muscle fiber types, specifically fast- and slow-twitch fibers, in young and middle-aged male rats, in relation ...
A 28-day subacute toxicity study of puberulic acid in Crl:CD(SD) rats [0.03%]
puberty酸Crl:CD(SD)rats亚急性毒性研究
Kohei Matsushita,Genichiro Tsuji,Hirotoshi Akane et al.
Kohei Matsushita et al.
In March 2024, a health hazard associated with the consumption of food products containing red yeast rice (beni-koji), which could lead to renal dysfunction, was reported in Japan. Puberulic acid (PA) was identified as an unintentional cont...
Effects of timing differences in γ-ray irradiation on ovarian development in rats [0.03%]
γ射线辐照时间不同对大鼠卵巢发育的影响
Dai Yamamoto,Junko Sato,Takuya Doi et al.
Dai Yamamoto et al.
This study investigated the effects on ovarian development in adult rats irradiated with γ-rays at fetal, neonatal, weaning, and early sexual maturation. Female Fischer-344 (F344) rats mated with male rats and their F1 offspring were irrad...
Momoka Shobudani,Yuzo Yasui,Akiko Anagawa-Nakamura et al.
Momoka Shobudani et al.
Ectopic intestinal cysts are extremely rare in the rat liver. Here, we report a case of a spontaneous ectopic intestinal cyst in the liver of an 8-week-old male Crl:CD (SD) rat. Necropsy revealed a solitary white, firm nodule, approximately...
Inactivation of major hepcidin pathways leads to systemic and hepatic iron overload during development of chemically-induced liver cirrhosis in rats [0.03%]
主要他利丁途径失活导致化学性肝硬化大鼠全身和肝脏铁过载
Takashi Horiuchi,Takeshi Izawa,Mitsuru Kuwamura
Takashi Horiuchi
Hepatic iron overload is a common complication of human chronic liver diseases, including liver cirrhosis; however, the underlying mechanisms remain unclear. In the present study, we investigated the temporal changes in iron metabolism and ...
Canine generalized ceroid lipofuscinosis characterized by predominant deposition in pancreatic acinar cells and intestinal smooth muscle cells [0.03%]
以胰腺外分泌细胞和平滑肌细胞着染为主的犬泛血管神经 ceroid-lipofuscinosis 病例报告
Ryoko Fujikawa,Kyohei Yasuno,Masako Imaoka et al.
Ryoko Fujikawa et al.
Canine generalized ceroid lipofuscinosis (GCL) is a rare disease characterized by the deposition of lipofuscin in systemic organs and tissues. In this case report, we encountered a dog with GCL and performed a detailed histopathological exa...