Tamami Suzuki,Rieru Kiyama,Paul Dela Cruz Valcorza et al.
Tamami Suzuki et al.
An 8-year-old male ferret was presented with dyspnea and large, palpable cervical masses. Pathological examination revealed multiple exophytic nodular masses arising from the atlas and axis. Those vertebrae were almost completely replaced b...
Tetsuro Kurotaki,Junko Sato,Minoru Tsuchitani
Tetsuro Kurotaki
Albino rats lack melanin production due to a defect in the tyrosinase gene. Melanomas arising in albino rats, which originate from neural crest cells, are non-melanin-producing and are referred to as amelanotic melanomas (AM). AM in albino ...
Retrospective and histopathological study on epithelial tumors in the rectum and anal canal of dogs [0.03%]
犬直肠和肛管上皮肿瘤的回顾性和组织病理学研究
Kento Ishikawa,James K Chambers,Ko Nakashima et al.
Kento Ishikawa et al.
Epithelial components of the rectum and anal canal comprise the rectal mucosa, anal canal mucosa, and anal glands. The clinicopathological characteristics of 111 cases of canine epithelial tumors in these regions were reviewed. Histopatholo...
Effect of single and repeated-dose oral administration of carbon tetrachloride on liver in zebrafish [0.03%]
单次和多次经口给药四氯化碳对斑马鱼肝效应研究
Satoshi Furukawa,Yukiko Nakajima,Naomi Fujiwara et al.
Satoshi Furukawa et al.
Acute toxicity and 14-day repeated-dose toxicity studies were performed via oral gavage to elucidate the effects of oral exposure to carbon tetrachloride (CCl4) on the liver of zebrafish. In the acute toxicity studies, the lethal dose 50% (...
Expression and distribution of tribbles pseudokinase 3 in oxidative stress-mediated acute liver and kidney injury models [0.03%]
氧化应激介导的急性肝肾损伤模型中假激酶Tribbles 3的表达及分布
Yukako Shimotsuma,Takeshi Izawa,Mitsuru Kuwamura
Yukako Shimotsuma
Tribbles pseudokinase 3 (Trib3) is an inactive protein kinase whose expression increases in response to various stresses. Our previous work showed that Trib3 may play a role in myelin destruction induced by oxidative and endoplasmic reticul...
Influence of rapamycin and chloroquine on chemically-induced liver injury in rats [0.03%]
雷帕霉素和氯喹对化学因素致大鼠肝损伤的影响
Sho Fujiwara,Takeshi Izawa,Mutsuki Mori et al.
Sho Fujiwara et al.
Drug-induced liver injury is a major reason for the discontinuation of drug development. Autophagy is a self-digestive process in the cell and can suppress cell death by removing damaged organelle from the cell. It is known that autophagy c...
Association between spontaneous neurogenic atrophy of the femoral muscle and islet cell tumors in aged F344 rats [0.03%]
老龄F344大鼠股外肌神经源性萎缩与胰岛细胞肿瘤的关联性研究
Mitsutoshi Uchida,Yumi Wako,Takeshi Kanno et al.
Mitsutoshi Uchida et al.
In aged F344/DuCrlCrlj rats, we observed that all animals with group atrophy of the biceps femoris muscle also had islet cell tumors, suggesting that spontaneous islet cell tumors may induce peripheral neuropathy and muscle atrophy. Among 2...
Evaluation of tumor clonality with chemical carcinogenesis in a mouse model of visualized X chromosome inactivation [0.03%]
视觉X染色体失活小鼠模型中化学致癌的肿瘤克隆性评价
Tomomi Maeda-Tateishi,Yuki Nagata,Yasuo Imanishi et al.
Tomomi Maeda-Tateishi et al.
Tumor clonality is determined by somatic mutations in genes that regulate cell proliferation, and this can be either monoclonal or multiclonal. Assays based on X-chromosome inactivation that exploit the random inactivation of one of the two...
A canine insulinoma with amphicrine differentiation: morphological and immunohistochemical characteristics [0.03%]
具有双分化的犬胰岛细胞瘤的形态和免疫组化特征
Hisaki Tokuno,Masashi Fujimoto,Makoto Tsuji et al.
Hisaki Tokuno et al.
A 10-year-old male toy poodle presented with hypoglycemia. An insulinoma was suspected and a surgical excision of two pancreatic masses was performed. White-gray, demarcated, soft masses were identified in the pancreas. Histopathologically,...
Intramuscular collagen accumulation in different types of skeletal muscle fibers in middle-aged male rats [0.03%]
中年雄性大鼠不同类型骨骼肌纤维内肌肉沉积的研究
Yoshikazu Taketa,Hideaki Takahashi
Yoshikazu Taketa
This study focused on the histological characterization of age-related intramuscular collagen accumulation in different skeletal muscle fiber types, specifically fast- and slow-twitch fibers, in young and middle-aged male rats, in relation ...