Spontaneous malignant myoepithelioma in the parotid gland of an aged female Crl:CD (SD) rat [0.03%]
老龄Crl：CD（SD）大鼠腮腺自发型恶性肌上皮瘤
Takuro Endo,Osamu Hashiguchi,Moeko Aoki et al.
Takuro Endo et al.
An aged female Crl:CD (SD) rat developed a subcutaneous tumor in the left occipital region. Histologically, the tumor was predominantly composed of spindle-shaped cells proliferating in a loosely cohesive fascicular arrangement in a basophi...
Evaluation of the skin carcinogenicity of the TRPV1 antagonist motugivatrep (SJP-0132) using an ultra-short-term two-stage skin carcinogenesis assay in Tg-rasH2 mice [0.03%]
采用Tg-rasH2小鼠超短期两阶段皮肤致癌试验评估TRPV1拮抗剂莫图非那雷（SJP-0132）的皮肤致癌性研究
Yoshinori Yamagiwa,Mayumi Kawabe,Yuko Doi et al.
Yoshinori Yamagiwa et al.
Motugivatrep (SJP-0132), a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist, is being developed as an ophthalmic drug for dry eye disease. Since the role of TRPV1 antagonists in skin carcinogenesis remains...
Multinucleation and cytotoxicity induced by multikinase inhibition in highly proliferative cells [0.03%]
多激酶抑制在高度增殖细胞中诱导的多核和细胞毒性
Emi Tomikawa,Kei Takahashi,Haruhiko Hattori et al.
Emi Tomikawa et al.
Phenotypic screening using motor neurons derived from the induced pluripotent stem (iPS) cell of a patient with amyotrophic lateral sclerosis led to the identification of Compound X, a novel agent with potent neuroprotective activity that i...
N-methyl- N-nitrosourea-induced forestomach neoplastic lesions formed by week 13 following a single intraperitoneal administration in rasH2 mice [0.03%]
单次腹腔注射NMU后rasH2小鼠瘤胃良性及恶性肿瘤病变的形成（时限为给药后的第13周）
Takamasa Numano,Ryo Inoue,Tatsuya Miyake et al.
Takamasa Numano et al.
CByB6F1-Tg (HRAS)2Jic mice (rasH2 mice) are widely used in 26-week short-term carcinogenicity assessments. To ensure phenotypic stability and carcinogenic sensitivity, a 26-week N-methyl-N-nitrosourea (MNU)-induced carcinogenic susceptibili...
INHAND: Non-proliferative and proliferative lesions of fish - Chapter 3. Fish digestive system [0.03%]
鱼的非增生性和增生性病变-INHAND 第3章 鱼类消化系统
Wes Baumgartner,Ute Bach,James Baily et al.
Wes Baumgartner et al.
INHAND: Non-proliferative and proliferative lesions of fish - Chapter 10. Fish male reproductive system [0.03%]
鱼的非增生性和增生性病变-第十章 雄鱼生殖系统
Wes Baumgartner,Ute Bach,James Baily et al.
Wes Baumgartner et al.
INHAND: Non-proliferative and proliferative lesions of fish - Chapter 15. Fish urinary system [0.03%]
鱼的非增生性和增生性病变-第15章 鱼的泌尿系统
Wes Baumgartner,Ute Bach,James Baily et al.
Wes Baumgartner et al.
INHAND: Non-proliferative and proliferative lesions of fish - Chapter 9. Fish female reproductive system [0.03%]
鱼类非增生性和增生性病变-INHAND-第9章 鱼类雌性生殖系统
Wes Baumgartner,Ute Bach,James Baily et al.
Wes Baumgartner et al.
INHAND: Non-proliferative and proliferative lesions of fish - Chapter 12. Fish skeletal and tooth [0.03%]
鱼类非增生性和增生性病变-INHAND-第12章 鱼类骨骼和牙齿异常
Wes Baumgartner,Ute Bach,James Baily et al.
Wes Baumgartner et al.