Identification and characterization of spontaneous AA amyloidosis in CD-1 mice used in toxicity studies: implications of SAA1 and SAA2 copy number variations [0.03%]
在毒性试验中用于实验的CD-1小鼠自发产生AA淀粉样变性的鉴定与表征：SAA1和SAA2拷贝数变异的意义
Mao Mizukawa,Kohei Tanaka,Akane Kashimura et al.
Mao Mizukawa et al.
Amyloidosis is characterized by the extracellular deposition of insoluble protein fibrils that cause cellular damage and dysfunction in organs and tissues. Multiple types of amyloidosis and their causative precursor proteins have been ident...
Lymphangiomas with the presence of erythrocytes in mesenteric lymph nodes of Wistar Hannover rats [0.03%]
郑妮尔斯-汉诺威大鼠肠系膜淋巴结出现红细胞的淋巴管瘤病理学观察
Yuumi Awazuhara,Yuki Tomonari,Hiroko Kokoshima et al.
Yuumi Awazuhara et al.
We performed morphological and immunohistochemical analyses of erythrocyte-rich vascular proliferative lesions of mesenteric lymph nodes in six male and one female Wistar Hannover rats. These lesions are conventionally diagnosed as hemangio...
High mobility group box1 as a danger signal inducing the infiltration of neutrophils and macrophages in thioacetamide-induced rat liver injury [0.03%]
硫代乙酰胺致大鼠肝损伤模型中高迁移率族蛋白箱1作为危险信号诱导中性粒细胞及巨噬细胞浸润的作用机制研究
Mizuki Kuramochi,Mohammad Rabiul Karim,Takeshi Izawa et al.
Mizuki Kuramochi et al.
The liver, a major organ involved in substance metabolism, is highly susceptible to toxicity induced by chemicals and their metabolites. Although damage-associated molecular patterns (DAMPs) have been implicated in the development of steril...
Histopathology of incidental non-neoplastic findings in transgenic CByB6F1-Tg(HRAS)2Jic mice used in toxicity studies [0.03%]
转基因CByB6F1-Tg(HRAS)2Jic小鼠在毒性试验中意外发现的非肿瘤性病理改变的Histopathology研究报告
Marcia E Pereira Bacares,Edward L Stevens,Victoria Laast et al.
Marcia E Pereira Bacares et al.
This technical report presents a collection of illustrative images and concise descriptions of non-neoplastic microscopic findings noted in transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) mice from 26-week-carcinogenicity studies. A unique findi...
Tokuma Yanai
Tokuma Yanai
In Japan, forensic medicine was established in the early 1900s to investigate potential criminal activities. However, only a few veterinary courses in forensic science are available, and the training of forensic specialists has lagged. This...
Atsuko Murai,Chisato Kaneko,Hisakazu Sanada et al.
Atsuko Murai et al.
The FVB/N mouse strain is widely used in transgenic studies and as a model for autoimmune diseases. Although spontaneous lesions have been reported in aged FVB/N mice, information regarding younger FVB/N mice is lacking. This study aimed to...
The relationship between spontaneous cystic degeneration and pseudocapillarization in sinusoids in the liver of aged Sprague-Dawley rats [0.03%]
老年Sprague-Dawley大鼠肝脏自发性囊状变性和肝窦假毛细血管化的关系研究
Atsushi Shiga,Chinatsu Fujiwara,Yoshitaka Katoh et al.
Atsushi Shiga et al.
Cystic degeneration (CD) in the liver is a cyst-like lesion composed of one or more pseudocysts lacking lining cells, occurring spontaneously in rats older than 12 months, with a male predilection. In this study, 32 CDs were identified in 2...
Spontaneous bilateral thyroid follicular cell carcinoma (subtype: compact cellular carcinoma) with C-cell complexes in a male beagle [0.03%]
自发性双侧甲状腺滤泡细胞癌（紧凑型细胞癌亚型）伴有C细胞复合物的雄性贝佳犬病例报告
Shingo Miyazaki,Takashi Ogawa,Tomoya Onozato et al.
Shingo Miyazaki et al.
We report the features of spontaneous bilateral thyroid follicular cell carcinoma in a 10-year-old male beagle. Necropsy revealed bilateral masses on the trachea, corresponding to the left and right sides of the thyroid gland. The masses we...
Protein overexpression by adeno-associated virus-based gene therapy products in cardiomyocytes induces endoplasmic reticulum stress and myocardial degeneration in mice [0.03%]
基于腺相关病毒的基因治疗产品在心肌细胞中过表达蛋白质会诱导小鼠内质网应激和心肌变性
Kyohei Yasuno,Ryo Watanabe,Rumiko Ishida et al.
Kyohei Yasuno et al.
Gene therapy (GT) products created using adeno-associated virus (AAV) vectors tend to exhibit toxicity via immune reactions, but other mechanisms of toxicity remain incompletely understood. We examined the cardiotoxicity of an overexpressed...
A 13-week subchronic toxicity study of linalool oxide in Crl:CD(SD) rats [0.03%]
β-石竹烯氧化物对CrI:CD(SD)鼠13周的次急性毒性研究
Mizuho Uneyama,Takeshi Toyoda,Yuko Doi et al.
Mizuho Uneyama et al.
Linalool oxide is frequently used as a flavoring agent, however, data on its toxicity is limited. In this study, we performed a 13-week subchronic toxicity study of linalool oxide (furanoid) in male and female Crl:CD(SD) rats. Doses of 0, 8...