Tomo Suzuki,Shoichi Kado,Minoru Ando et al.
Tomo Suzuki et al.
Cardiac hypertrophy was observed in a 9-week-old Crl:CD(SD) rat that died unexpectedly. The animal was allocated to the control group of a toxicity study, and no abnormalities in its general conditions, body weight or food intake were obser...
George Ohta,Masato Kobayashi,Hiroki Sakai et al.
George Ohta et al.
The proliferative potential of a spinal nephroblastoma was studied in a young dog. A 4-month-old, female golden retriever showed developing deterioration in her gait and subsequent paralysis of her hind legs. At necropsy, a well-demarcated ...
Lung Carcinogenic Bioassay of CuO and TiO(2) Nanoparticles with Intratracheal Instillation Using F344 Male Rats [0.03%]
纳米CuO和TiO(2)颗粒气管内给药诱导雄性F344大鼠肺癌的致癌试验
Masanao Yokohira,Nozomi Hashimoto,Keiko Yamakawa et al.
Masanao Yokohira et al.
Toxicity assessment of nanoparticles, now widespread in our environment, is an important issue. We have focused attention on the carcinogenic potential of copper oxide (CuO) and titanium dioxide (TiO(2)). In experiment 1, a sequential pilot...
Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker [0.03%]
基于对结肠癌替代标志物分析的证据乙醇不促进MeIQx诱导的大鼠结肠致癌作用
Masahiko Kushida,Hideki Wanibuchi,Min Wei et al.
Masahiko Kushida et al.
Epidemiological studies suggest that alcohol consumption increases the risk of developing colorectal cancer. However, the data are confounded by numerous cosegregating variables. To cast further light on the relationships between alcohol in...
Hiroto Miyata,Fumiko Asanuma,Yoshinobu Iwaki et al.
Hiroto Miyata et al.
The purpose of this study was to clarify the effect of decreased food consumption on evaluation of myelotoxicity in routine general toxicity studies. Male rats were divided into the following 7 groups: 12, 15, and 18 mg/kg 5-fluorouracil (5...
Naoki Kiyosawa,Yosuke Ando,Sunao Manabe et al.
Naoki Kiyosawa et al.
Toxicogenomics (TGx) is a widely used technique in the preclinical stage of drug development to investigate the molecular mechanisms of toxicity. A number of candidate TGx biomarkers have now been identified and are utilized for both assess...
Biological Basis of Differential Susceptibility to Hepatocarcinogenesis among Mouse Strains [0.03%]
小鼠品系肝细胞癌发生的差异易感性的生物学基础
Robert R Maronpot
Robert R Maronpot
There is a vast amount of literature related to mouse liver tumorigenesis generated over the past 60 years, not all of which has been captured here. The studies reported in this literature have generally been state of the art at the time th...
An intratracheal instillation bioassay system for detection of lung toxicity due to fine particles in f344 rats [0.03%]
大鼠经气管给药肺毒理学评价体系构建及应用研究
Masanao Yokohira,Toshiya Kuno,Keiko Yamakawa et al.
Masanao Yokohira et al.
It is an urgent priority to establish in vivo bioassays for detection of hazards related to fine particles, which can be inhaled into deep lung tissue by humans. In order to establish an appropriate bioassay for detection of lung damage aft...