Therapeutic antibodies: technical points to consider in tissue cross-reactivity studies [0.03%]
治疗性抗体：组织交叉反应性研究中需要考虑的技术问题
Etsuko Fujii,Atsuhiko Kato
Etsuko Fujii
Tissue cross-reactivity (TCR) studies for the development of therapeutic antibodies are conducted to estimate any possible binding sites within the human body that can be affected by the antibody when assessing safety in humans. Any possibl...
Spontaneous histopathology in New Zealand White rabbits: ten years of control data [0.03%]
新西兰兔自发性病理学十年控制数据
Erica Eggers Carroll,Amit Kumar,Pedro Romao et al.
Erica Eggers Carroll et al.
The historical control database of a multinational laboratory services provider was queried for all histopathologic findings in New Zealand White rabbits which were used as control animals during a ten-year period (2011-2020). The query inc...
Spontaneous histiocytic sarcoma originating from the epididymis in a CD-1 mouse [0.03%]
CD-1小鼠自发性附睾来源的朗格汉斯细胞组织细胞增生症伴肉瘤形成
Taishi Shimazaki,Yuzo Yasui,Akiko Anagawa-Nakamura et al.
Taishi Shimazaki et al.
We report a histiocytic sarcoma originating from the epididymis observed in a 110-week-old male CD-1 mouse in a carcinogenicity study. At necropsy, no lesions were observed in the epididymis. Histologically, a neoplastic lesion was observed...
Ryo D Obara,Yuki Kato,Yoshiji Asaoka et al.
Ryo D Obara et al.
Duplicate testes lined in series were observed in the right scrotum of a 6-week-old Sprague-Dawley rat in a single-dose toxicity study. Of the two right testicles, one was spherical and less than half the size of a normal testis. The other ...
Combination of pathological, biochemical and behavioral evaluations for peripheral neurotoxicity assessment in isoniazid-treated rats [0.03%]
异烟肼致大鼠外周神经毒性的病理、生化和行为综合评价方法研究
Akane Kashimura,Satomi Nishikawa,Yuhei Ozawa et al.
Akane Kashimura et al.
In drug development, assessment of non-clinical peripheral neurotoxicity is important to ensure human safety. Clarifying the pathological features and mechanisms of toxicity enables the management of safety risks in humans by estimating the...
Drug review process advancement and required manufacturer and contract research oraganization responses [0.03%]
药物审评流程进展及对申办方和合同研究组织的要求响应
Takayuki Anzai,Glenn J Myatt,Frances Hall et al.
Takayuki Anzai et al.
The United States Senate passed the "FDA Modernization Act 2.0." on September 29, 2022. Although the effectiveness of this Bill, which aims to eliminate the mandatory use of laboratory animals in new drug development, is limited, it represe...
Induction of lung lesions by bronchial administration using bronchoscope technique in mice [0.03%]
支气管镜技术介导的气道内给药诱导小鼠肺部病变模型的研究
Takako Hiyoshi,Chiyoko Nishime,Eiko Nishinaka et al.
Takako Hiyoshi et al.
This study aimed to establish an exposure method that can induce homogeneous lesions with minimal inter-individual variability. The distribution of lesions induced by bleomycin (BLM) administration was also analyzed. C57BL mice were intrabr...
CD44 expression in renal tubular epithelial cells in the kidneys of rats with cyclosporine-induced chronic kidney disease [0.03%]
环孢素致慢性肾脏病大鼠肾小管上皮细胞CD44表达
Kohei Matsushita,Takeshi Toyoda,Hirotoshi Akane et al.
Kohei Matsushita et al.
Renal tubular epithelial cell (TEC) injury is the most common cause of drug-induced kidney injury (DIKI). Although TEC regeneration facilitates renal function and structural recovery following DIKI, maladaptive repair of TECs leads to irrev...
Neural tissue tolerance to synthetic dural mater graft implantation in a rabbit durotomy model [0.03%]
一种合成硬脑膜移植物在兔硬脑膜切开模型中的神经耐受研究
Yuval Ramot,Noam Kronfeld,Michal Steiner et al.
Yuval Ramot et al.
In neurosurgical interventions, effective closure of the dura mater is essential to prevent cerebrospinal fluid leakage and minimize post-operative complications. Biodegradable synthetic materials have the potential to be used as dura mater...
Lobular distribution of enhanced expression levels of heat shock proteins using in-situ hybridization in the mouse liver treated with a single administration of CCl4 [0.03%]
单次CCl4处理的小鼠肝脏中热休克蛋白表达水平增强的原位杂交定位分布研究
Hitoshi Kandori,Masami Aoki,Yumiko Miyamoto et al.
Hitoshi Kandori et al.
This study was conducted to visualize the lobular distribution of enhanced mRNA expression levels of heat shock proteins (HSPs) in liver samples from carbon tetra chloride (CCl4)-treated mice using in-situ hybridization (ISH). Male BALB/c m...