Lymphocytic thyroiditis with an oncocytic alteration in a laboratory beagle [0.03%]
具有上皮细胞化生的淋巴细胞性甲状腺炎的一个实验室比格犬病例报告
Osamu Hashiguchi,Kohji Tanaka,Yuko Yamaguchi et al.
Osamu Hashiguchi et al.
Histopathological, immunohistochemical, and ultrastructural characteristics of lymphocytic thyroiditis in an untreated four-year-old male beagle were described. Histopathologically, the thyroid glands were composed of two distinct cell type...
Application of humanized mice to toxicology studies: properties of chimeric mice with humanized liver (PXB-mice) for hepatotoxicity [0.03%]
人源化小鼠在毒理学研究中的应用：具有人肝嵌合组织（PXB小鼠）的特性用于肝毒性研究
Nazneen Sultana,Takeshi Izawa,Tomomi Kamei et al.
Nazneen Sultana et al.
Chimeric mice with humanized liver are considered a useful tool to predict drug pharmacokinetics and in vivo toxicity in humans. The PXB-mouse is one of such chimeric (humanized) mouse models with more than 70% of human hepatocytes in their...
Masaki Fujioka,Shugo Suzuki,Min Gi et al.
Masaki Fujioka et al.
Tobacco smoking is a major risk factor for human cancers including urinary bladder carcinoma. In a previous study, nicotine was shown to enhance rat urinary bladder carcinogenesis in a two-stage carcinogenesis model. In this study, we exami...
A concise review of veterinary forensic medicine in Japan: current status and perspectives [0.03%]
日本兽医法医学概论：现状与展望
Shin-Ichi Nakamura
Shin-Ichi Nakamura
Veterinary forensic medicine has received increasing attention in recent years from the perspectives of animal abuse, veterinary malpractice, wildlife protection, and zoonosis. Veterinary forensic medicine, equivalent to human forensic medi...
Novel three-dimensional analysis method for accurate evaluation of cutaneous small sensory nerve fibers in mice [0.03%]
一种用于小鼠皮肤小型感觉神经纤维的精确评价的新三维分析方法
Minori Inanaga- Kojima,Tetsuro Matsuura,Kiyokazu Ozaki
Minori Inanaga- Kojima
Intraepidermal nerve fiber (IENF) density is commonly evaluated to diagnose peripheral neuropathy. However, conventional two-dimensional (2D) analysis using rodent models shows high interstudy variability. Three-dimensional (3D) IENF analys...
Comparative analysis of the toxic effects on the mouse lung of 4 weeks exposure to the heated tobacco product Ploom TECH+ and 3R4F reference cigarettes [0.03%]
Ploom TECH+加热烟草产品和3R4F参考卷烟对小鼠肺毒性的比较分析
Ikue Noura,Shugo Suzuki,Min Gi et al.
Ikue Noura et al.
Pulmonary emphysema is primarily attributable to prolonged exposure to cigarette smoke. Novel tobacco substitutes, such as heated tobacco products, have emerged as healthier alternatives to cigarettes. The effects of short-term inhalation o...
Comparative anatomy of respiratory bronchioles and lobular structures in mammals [0.03%]
哺乳动物呼吸性细支气管和肺小叶结构的比较解剖学
Yumi Umeda,Takeshi Izawa,Kei Kazama et al.
Yumi Umeda et al.
Rodents are widely used to study the toxicity of chemicals; however, differences between species indicate that the results from rodents are not always directly transferable to humans. The health of workers exposed to various chemicals and p...
Time-course of changes in fibrous components in a thioacetamide-induced liver fibrosis model in cynomolgus monkeys [0.03%]
猕猴噻唑烷酮诱导的肝纤维化模型中纤维成分的变化规律研究
Miwa Takahashi,Mihoko Ono,Satoru Kajikawa et al.
Miwa Takahashi et al.
In liver fibrosis, the possible causes of irreversibility include the accumulation of collagen I during extracellular matrix remodeling, together with the deposition of elastic fibers in later stages. Drug development targeting liver fibros...
The role of mitochondrial reactive oxygen species in initiating mitochondrial damage and inflammation in wasp-venom-induced acute kidney injury [0.03%]
黄蜂毒液诱导的急性肾损伤中线粒体反应性氧簇引发线粒体损伤和炎症的作用
Lingya Xia,Hai Yuan,Zhao Gao et al.
Lingya Xia et al.
Acute kidney injury induced by stings from multiple wasps is a medical emergency and is a driving factor of acute renal dysfunction. Numerous studies have shown that mitochondrial reactive oxygen species (mtROS) play a key role in ischemia-...
Metabolism and effects of acetoaceto- o-toluidine in the urinary bladder of humanized-liver mice [0.03%]
乙酰乙酸-o- toluidine在人类肝小鼠膀胱中的代谢和影响
Shugo Suzuki,Min Gi,Yukie Yanagiba et al.
Shugo Suzuki et al.
Occupational exposure to aromatic amines is a major risk factor for urinary bladder cancer. Our previous studies showed that acetoaceto-o-toluidine, which is produced using o-toluidine as a raw material, promotes urinary bladder carcinogene...