Atsuko Murai,Chisato Kaneko,Hisakazu Sanada et al.
Atsuko Murai et al.
The FVB/N mouse strain is widely used in transgenic studies and as a model for autoimmune diseases. Although spontaneous lesions have been reported in aged FVB/N mice, information regarding younger FVB/N mice is lacking. This study aimed to...
The relationship between spontaneous cystic degeneration and pseudocapillarization in sinusoids in the liver of aged Sprague-Dawley rats [0.03%]
老年Sprague-Dawley大鼠肝脏自发性囊状变性和肝窦假毛细血管化的关系研究
Atsushi Shiga,Chinatsu Fujiwara,Yoshitaka Katoh et al.
Atsushi Shiga et al.
Cystic degeneration (CD) in the liver is a cyst-like lesion composed of one or more pseudocysts lacking lining cells, occurring spontaneously in rats older than 12 months, with a male predilection. In this study, 32 CDs were identified in 2...
Spontaneous bilateral thyroid follicular cell carcinoma (subtype: compact cellular carcinoma) with C-cell complexes in a male beagle [0.03%]
自发性双侧甲状腺滤泡细胞癌（紧凑型细胞癌亚型）伴有C细胞复合物的雄性贝佳犬病例报告
Shingo Miyazaki,Takashi Ogawa,Tomoya Onozato et al.
Shingo Miyazaki et al.
We report the features of spontaneous bilateral thyroid follicular cell carcinoma in a 10-year-old male beagle. Necropsy revealed bilateral masses on the trachea, corresponding to the left and right sides of the thyroid gland. The masses we...
Protein overexpression by adeno-associated virus-based gene therapy products in cardiomyocytes induces endoplasmic reticulum stress and myocardial degeneration in mice [0.03%]
基于腺相关病毒的基因治疗产品在心肌细胞中过表达蛋白质会诱导小鼠内质网应激和心肌变性
Kyohei Yasuno,Ryo Watanabe,Rumiko Ishida et al.
Kyohei Yasuno et al.
Gene therapy (GT) products created using adeno-associated virus (AAV) vectors tend to exhibit toxicity via immune reactions, but other mechanisms of toxicity remain incompletely understood. We examined the cardiotoxicity of an overexpressed...
A 13-week subchronic toxicity study of linalool oxide in Crl:CD(SD) rats [0.03%]
β-石竹烯氧化物对CrI:CD(SD)鼠13周的次急性毒性研究
Mizuho Uneyama,Takeshi Toyoda,Yuko Doi et al.
Mizuho Uneyama et al.
Linalool oxide is frequently used as a flavoring agent, however, data on its toxicity is limited. In this study, we performed a 13-week subchronic toxicity study of linalool oxide (furanoid) in male and female Crl:CD(SD) rats. Doses of 0, 8...
Spontaneous B-cell lymphoma in the cranial mediastinal lymph node of an aged male C57BL/6J mouse [0.03%]
老龄C57BL/6J雄小鼠颅中窝淋巴结B细胞淋巴瘤的自发发生
Shoko Suzuki,Mao Mizukawa,Akane Kashimura et al.
Shoko Suzuki et al.
B-cell lymphoma is generally observed in the spleen, mesenteric lymph nodes, and Peyer's patches in aged mice and rarely appears in other organs. Herein, we report a case of spontaneous B-cell lymphoma originating from the cranial mediastin...
Optimal testing time for cerebral heterotopia formation in the rat comparative thyroid assay, a downstream indicator for perinatal thyroid hormone insufficiency [0.03%]
大鼠比较性甲状腺试验的最优检测时间：幼年期甲状腺激素不足的下游指标
Keiko Ogata,Hidenori Suto,Akira Sato et al.
Keiko Ogata et al.
In a past study, we proposed a modified Comparative Thyroid Assay (CTA) with additional examinations of brain thyroid hormone (TH) concentrations and brain histopathology but with smaller group sizes. The results showed that the modified CT...
Natural outbreak of Mycobacterium caprae infection in imported laboratory cynomolgus macaques (Macaca fascicularis): diagnostic pitfalls and management of safety precautions [0.03%]
实验猴感染分枝杆菌的自然暴发：诊断陷阱与安全管理措施
Klaus Weber,Francisco José Mayoral,Carla Vallejo et al.
Klaus Weber et al.
Tuberculosis (TB) is a major health threat for humans and for non-human primates used for toxicology or research purposes. Emerging mycobacterial species represent a major challenge for diagnosis and surveillance programs. Here, we report a...
Satoshi Furukawa,Naho Tsuji,Kazuya Takeuchi
Satoshi Furukawa
We examined the morphological effects of letrozole on placental development in pregnant rats. Letrozole was orally administered at a repeat dose to pregnant rats at 0 mg/kg (control group) and 0.04 mg/kg (letrozole group) from gestation day...
Immunohistochemical characteristics of cytokeratin expression in epithelial type thymoma and thymic epithelial hyperplasia in F344 rats [0.03%]
F344大鼠胸腺上皮型胸腺瘤及胸腺上皮增生的细胞角蛋白免疫组化特征研究
Yuki Tomonari,Junko Sato,Mitsutoshi Uchida et al.
Yuki Tomonari et al.
We have previously reported on thymomas in Wistar Hannover rats with medullary differentiation and revealed that two different cytokeratin (CK) immunohistochemical types of thymic epithelia (TE), CK18 and CK14, lead to the formation of cort...