Comparative analysis of the toxic effects on the mouse lung of 4 weeks exposure to the heated tobacco product Ploom TECH+ and 3R4F reference cigarettes [0.03%]
Ploom TECH+加热烟草产品和3R4F参考卷烟对小鼠肺毒性的比较分析
Ikue Noura,Shugo Suzuki,Min Gi et al.
Ikue Noura et al.
Pulmonary emphysema is primarily attributable to prolonged exposure to cigarette smoke. Novel tobacco substitutes, such as heated tobacco products, have emerged as healthier alternatives to cigarettes. The effects of short-term inhalation o...
Comparative anatomy of respiratory bronchioles and lobular structures in mammals [0.03%]
哺乳动物呼吸性细支气管和肺小叶结构的比较解剖学
Yumi Umeda,Takeshi Izawa,Kei Kazama et al.
Yumi Umeda et al.
Rodents are widely used to study the toxicity of chemicals; however, differences between species indicate that the results from rodents are not always directly transferable to humans. The health of workers exposed to various chemicals and p...
Time-course of changes in fibrous components in a thioacetamide-induced liver fibrosis model in cynomolgus monkeys [0.03%]
猕猴噻唑烷酮诱导的肝纤维化模型中纤维成分的变化规律研究
Miwa Takahashi,Mihoko Ono,Satoru Kajikawa et al.
Miwa Takahashi et al.
In liver fibrosis, the possible causes of irreversibility include the accumulation of collagen I during extracellular matrix remodeling, together with the deposition of elastic fibers in later stages. Drug development targeting liver fibros...
The role of mitochondrial reactive oxygen species in initiating mitochondrial damage and inflammation in wasp-venom-induced acute kidney injury [0.03%]
黄蜂毒液诱导的急性肾损伤中线粒体反应性氧簇引发线粒体损伤和炎症的作用
Lingya Xia,Hai Yuan,Zhao Gao et al.
Lingya Xia et al.
Acute kidney injury induced by stings from multiple wasps is a medical emergency and is a driving factor of acute renal dysfunction. Numerous studies have shown that mitochondrial reactive oxygen species (mtROS) play a key role in ischemia-...
Metabolism and effects of acetoaceto- o-toluidine in the urinary bladder of humanized-liver mice [0.03%]
乙酰乙酸-o- toluidine在人类肝小鼠膀胱中的代谢和影响
Shugo Suzuki,Min Gi,Yukie Yanagiba et al.
Shugo Suzuki et al.
Occupational exposure to aromatic amines is a major risk factor for urinary bladder cancer. Our previous studies showed that acetoaceto-o-toluidine, which is produced using o-toluidine as a raw material, promotes urinary bladder carcinogene...
Identification and characterization of spontaneous AA amyloidosis in CD-1 mice used in toxicity studies: implications of SAA1 and SAA2 copy number variations [0.03%]
在毒性试验中用于实验的CD-1小鼠自发产生AA淀粉样变性的鉴定与表征：SAA1和SAA2拷贝数变异的意义
Mao Mizukawa,Kohei Tanaka,Akane Kashimura et al.
Mao Mizukawa et al.
Amyloidosis is characterized by the extracellular deposition of insoluble protein fibrils that cause cellular damage and dysfunction in organs and tissues. Multiple types of amyloidosis and their causative precursor proteins have been ident...
Lymphangiomas with the presence of erythrocytes in mesenteric lymph nodes of Wistar Hannover rats [0.03%]
郑妮尔斯-汉诺威大鼠肠系膜淋巴结出现红细胞的淋巴管瘤病理学观察
Yuumi Awazuhara,Yuki Tomonari,Hiroko Kokoshima et al.
Yuumi Awazuhara et al.
We performed morphological and immunohistochemical analyses of erythrocyte-rich vascular proliferative lesions of mesenteric lymph nodes in six male and one female Wistar Hannover rats. These lesions are conventionally diagnosed as hemangio...
High mobility group box1 as a danger signal inducing the infiltration of neutrophils and macrophages in thioacetamide-induced rat liver injury [0.03%]
硫代乙酰胺致大鼠肝损伤模型中高迁移率族蛋白箱1作为危险信号诱导中性粒细胞及巨噬细胞浸润的作用机制研究
Mizuki Kuramochi,Mohammad Rabiul Karim,Takeshi Izawa et al.
Mizuki Kuramochi et al.
The liver, a major organ involved in substance metabolism, is highly susceptible to toxicity induced by chemicals and their metabolites. Although damage-associated molecular patterns (DAMPs) have been implicated in the development of steril...
Histopathology of incidental non-neoplastic findings in transgenic CByB6F1-Tg(HRAS)2Jic mice used in toxicity studies [0.03%]
转基因CByB6F1-Tg(HRAS)2Jic小鼠在毒性试验中意外发现的非肿瘤性病理改变的Histopathology研究报告
Marcia E Pereira Bacares,Edward L Stevens,Victoria Laast et al.
Marcia E Pereira Bacares et al.
This technical report presents a collection of illustrative images and concise descriptions of non-neoplastic microscopic findings noted in transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) mice from 26-week-carcinogenicity studies. A unique findi...
Tokuma Yanai
Tokuma Yanai
In Japan, forensic medicine was established in the early 1900s to investigate potential criminal activities. However, only a few veterinary courses in forensic science are available, and the training of forensic specialists has lagged. This...