The potential of organoids in toxicologic pathology: role of toxicologic pathologists in in vitro chemical hepatotoxicity assessment [0.03%]
类器官在毒理病理学中的潜力：体外化学肝毒性评估中毒理病理学家的作用
Toshinori Yoshida,Mio Kobayashi,Suzuka Uomoto et al.
Toshinori Yoshida et al.
The development of in vitro toxicity assessment methods using cultured cells has gained popularity for promoting animal welfare in animal experiments. Herein, we briefly discuss the current status of hepatoxicity assessment using human- and...
Response biomarkers of inhalation exposure to cigarette smoke in the mouse lung [0.03%]
小鼠肺部吸入香烟烟雾暴露的反应生物标志物
Shugo Suzuki,Kazuhisa Asai,Min Gi et al.
Shugo Suzuki et al.
Cigarette smoking is known to increase the risk of cancer and chronic obstructive pulmonary disease (COPD). In this study, we evaluated the effects of short-term nose-only inhalation exposure to cigarette smoke in mice. Male 10-week-old C57...
Microarray-based gene expression analysis combined with laser capture microdissection is beneficial in investigating the modes of action of ocular toxicity [0.03%]
结合激光捕获微切割的基因表达芯片分析技术有利于研究眼部毒性的作用机制
Makoto Shirai,Noriyo Niino,Kazuhiko Mori et al.
Makoto Shirai et al.
The retina consists of several layers, and drugs can affect the retina and choroid separately. Therefore, investigating the target layers of toxicity can provide useful information pertaining to its modes of action. Herein, we compared gene...
LPS-TLR4/MD-2-TNF-α signaling mediates alcohol-induced liver fibrosis in rats [0.03%]
LPS-TLR4/MD-2-TNF-α信号介导的大鼠酒精性肝纤维化作用机制研究
Wen-Ling Mou,Shi-Ru Chen,Zhen-Ting Wu et al.
Wen-Ling Mou et al.
Liver fibrosis results from liver inflammation and progresses to liver cirrhosis or liver cancer. It is known that nonalcoholic liver disease is mediated by the Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2)-tumor necro...
Deep learning-based image-analysis algorithm for classification and quantification of multiple histopathological lesions in rat liver [0.03%]
基于深度学习的图像分析算法在大鼠肝脏多种病理损伤的分类和定量中的应用研究
Taishi Shimazaki,Ameya Deshpande,Anindya Hajra et al.
Taishi Shimazaki et al.
Artificial intelligence (AI)-based image analysis is increasingly being used for preclinical safety-assessment studies in the pharmaceutical industry. In this paper, we present an AI-based solution for preclinical toxicology studies. We tra...
CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet [0.03%]
胆碱缺乏蛋氨酸降低的L氨基酸饮食诱导的非酒精性steatohepatitis大鼠模型胆管上皮细胞CD44表达与肝纤维化的关系研究
Kinuko Uno,Katsuhiro Miyajima,Marika Toma et al.
Kinuko Uno et al.
Nonalcoholic steatohepatitis is a lifestyle-related disease and an increasing threat worldwide. Hepatic fibrosis, which results from chronic hepatic diseases including nonalcoholic steatohepatitis, is closely correlated with mortality among...
Yui Terayama,Tetsuro Matsuura,Kiyokazu Ozaki
Yui Terayama
Primary splenic stromal tumors have rarely been reported in rodents. We report the case of a 90-week-old male WBN/Kob rat with a nodular demarcated mass in the spleen, which was kept as a non-treated animal in a long-term animal study. Hist...
Elevated level of microRNA-210 at the initiation of muscular regeneration in acetic acid-induced non-ischemic skeletal muscular injury in mice [0.03%]
冰醋酸致小鼠非缺血性骨骼肌损伤再生启动时微小核糖核酸-210水平升高
Yuichi Takai,Takeshi Watanabe,Tomoya Sano
Yuichi Takai
The alteration in microRNA-210 level, a hypoxia-inducible microRNA, is not well known in non-ischemic tissue injury. In this study, we characterized the histopathological time course of acetic acid-induced skeletal muscle injury as a non-is...
Testicular alterations in cryptorchid/orchiopexic rats chronically exposed to acrylamide or di-butyl-phthalate [0.03%]
长期暴露于丙烯酰胺或邻苯二甲酸二丁酯的隐睾或腹股沟固定大鼠的睾丸改变
Thania R R Lima,Nathália P Souza,Ana P Ferragut Cardoso et al.
Thania R R Lima et al.
Exposure of Sprague-Dawley (SD) rats to acrylamide (AA) or di-butyl-phthalate (DBP) from the 12th gestational day to the 16th postnatal week (PNW) has been shown to reduce the effectiveness of orchiopexy in recovering the testicular alterat...
Histopathological changes of the spinal cord and motor neuron dynamics in SOD1 Tg mice [0.03%]
SOD1转基因小鼠脊髓的组织病理改变及运动神经元动态变化
Masaharu Tanaka,Kengo Homma,Aki Soejima
Masaharu Tanaka
We analyzed the histopathological changes and the number of motor neurons (MNs) in the lumbar spinal cord of Cu/Zn superoxide dismutase transgenic (SOD1G93ATg) mice, which are frequently used as a disease model of amyotrophic lateral sclero...