Structure of cytochrome c' from Rhodobacter capsulatus strain St Louis: an unusual molecular association induced by bridging Zn ions [0.03%]
产硫红螺菌株St Louis血红素c’的结构：由桥连Zn离子诱导的一种特殊的分子结合方式
T H Tahirov,S Misaki,T E Meyer et al.
T H Tahirov et al.
Rhodobacter capsulatus strain St Louis cytochrome c' (RCCP-SL) has been crystallized and the structure solved by molecular replacement. It was refined at 2.1 A resolution to an R value of 18.4%, and compared with Rhodobacter capsulatus stra...
X-ray structure of turkey-egg lysozyme complex with tri-N-acetylchitotriose. Lack of binding ability at subsite A [0.03%]
与三-N-乙酰-D-葡萄糖胺-D-半乳糖胺脎复合的火鸡卵溶菌酶的X射线结构。A位点没有结合能力
K Harata,M Muraki
K Harata
The turkey-egg lysozyme (TEL) complex with tri-N-acetylchitotriose [(GlcNac)3] was co-crystallized from 1.5% TEL and 2 mM (GlcNac)3 at pH 4.2. The crystal structure was determined by molecular replacement and refined to an R value of 0.182 ...
Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate [0.03%]
曲霉属肺孢子菌和野生型人二氢叶酸还原酶三元复合体与辅酶NADPH及一种新的抗肿瘤呋喃[2，3-D]嘧啶类抗叶酸的比较研究
V Cody,N Galitsky,J R Luft et al.
V Cody et al.
The novel furopyrimidine N-(4-{N-[(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)methyl]methylamino}benzoyl)-L- glutamate (MTXO), a classical antifolate with antitumor activity comparable to that of methotrexate (MTX), has been studied as inhibitor-...
Determinants of backbone packing in globular proteins: an analysis of spatial neighbours [0.03%]
球状蛋白质主链排列的决定因素：空间邻近残基分析
S K Panjikar,M Biswas,S Vishveshwara
S K Panjikar
This study attempts to examine the pattern and variability of backbone packing density in protein structures. A carefully selected non-redundant data set of known protein structures is analyzed in terms of amino-acid composition and the pre...
Crystallization and preliminary structure of porcine aldehyde reductase-NADPH binary complex [0.03%]
猪醛还原酶-NADPH二元复合物的结晶及初步结构分析
O El-Kabbani,K Judge,S L Ginell et al.
O El-Kabbani et al.
Porcine aldehyde reductase-NADPH binary complex has been crystallized from a buffered ammonium sulfate solution. The crystal form is hexagonal, space group P6(5)22, with a = b = 67.2, c = 243.7 A, alpha = beta = 90.0 and gamma = 120.0 degre...
I Botos,L Scapozza,J D Shannon et al.
I Botos et al.
A theoretical study was performed on the structure of both the native and inhibited metalloproteinase Ht-d (E.C. 3.4.24.42) solved at 2.0 A resolution. The energy maps calculated by program GRID clearly showed the extended binding site of H...
Crystallographic and thermodynamic comparison of structurally diverse molecules binding to streptavidin [0.03%]
结晶学和热力学对比结构各异的分子与链霉亲和素结合的情况
P C Weber,M W Pantoliano,F R Salemme
P C Weber
Crystallographic structures and thermodynamic binding parameters are compared for three structural classes of streptavidin ligand including d-biotin, 2-[(4'-hydroxyphenyl)-azo] benzoate and the peptide NH(2)-Phe-Ser-His-Pro-Gln-Asn-Thr-COOH...
Refined 3.2 A structure of glycosomal holo glyceraldehyde phosphate dehydrogenase from Trypanosoma brucei brucei [0.03%]
布鲁氏锥虫甘油醛-3-磷酸脱氢酶包涵体的结构
F M Vellieux,J Hajdu,W G Hol
F M Vellieux
The three-dimensional crystal structure of the enzyme glyceraldehyde phosphate dehydrogenase from the kinetoplastid Trypanosoma brucei brucei has been determined at 3.2 A resolution from a 37% complete data set collected using the Laue meth...
A comparison of two independently determined structures of trypanothione reductase from Crithidia fasciculata [0.03%]
来自Crithidia fasciculata的两种独立确定的转铁素还原酶结构的比较
C S Bond,A H Fairlamb,W N Hunter
C S Bond
The enzyme trypanothione reductase (TR) is unique to trypanosomes and leishmania parasites, the causal agents of several important medical and veterinary tropical diseases. TR helps regulate the intracellular reducing environment of the par...
Correlation of binding affinities with non-bonded interaction energies of thrombin-inhibitor complexes [0.03%]
凝血酶抑制剂复合物结合亲和力与非键相互作用能量的关联性研究
P D Grootenhuis,P J van Galen
P D Grootenhuis
Several empirical modeling protocols are evaluated allowing a quantification of the interaction between an enzyme and a series of inhibitors. The evaluation and optimization of the modeling protocols used a database of 35 non-covalently bou...