Exploring structural variability in X-ray crystallographic models using protein local optimization by torsion-angle sampling [0.03%]
基于扭转角取样法的蛋白质局部优化在X射线晶体学模型结构变化性中的应用探索
Jennifer L Knight,Zhiyong Zhou,Emilio Gallicchio et al.
Jennifer L Knight et al.
Modeling structural variability is critical for understanding protein function and for modeling reliable targets for in silico docking experiments. Because of the time-intensive nature of manual X-ray crystallographic refinement, automated ...
Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii [0.03%]
来源于甲烷球菌的N47A和E109Q突变体蛋白的丙酮酸依赖精氨酸脱羧酶结构研究
Erika V Soriano,Diane E McCloskey,Cynthia Kinsland et al.
Erika V Soriano et al.
Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) catalyzes the first step of the polyamine-biosynthetic pathway in plants and some archaebacteria. The pyruvoyl group of PvlArgDC is generated by an internal autoserinolysis reaction at an...
Structural adaptation of endonuclease I from the cold-adapted and halophilic bacterium Vibrio salmonicida [0.03%]
来自低温和盐适应细菌Vibrio salmonicida的内切酶I的结构适应性
Bjørn Altermark,Ronny Helland,Elin Moe et al.
Bjørn Altermark et al.
The crystal structure of the periplasmic/extracellular endonuclease I from Vibrio salmonicida has been solved to 1.5 A resolution and, in comparison to the corresponding endonucleases from V. cholerae and V. vulnificus, serves as a model sy...
Towards a rational approach for heavy-atom derivative screening in protein crystallography [0.03%]
蛋白晶体学中重原子衍生物筛选的理性方法探讨
Johnson Agniswamy,M Gordon Joyce,Carl H Hammer et al.
Johnson Agniswamy et al.
Heavy-atom derivatization is routinely used in protein structure determination and is thus of critical importance in structural biology. In order to replace the current trial-and-error heavy-atom derivative screening with a knowledge-based ...
Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin [0.03%]
与特异性DARPin结合的野生型Plk-1激酶结构域复合物的结构
Tiago M Bandeiras,Roman Christian Hillig,Pedro M Matias et al.
Tiago M Bandeiras et al.
As a key regulator of mitosis, the Ser/Thr protein polo-like kinase-1 (Plk-1) is a well validated drug target in cancer therapy. In order to enable structure-guided drug design, determination of the crystal structure of the kinase domain of...
Deposition of diffraction images to be discussed at the Open Meeting of the Commission on Biological Macromolecules of the IUCr in Osaka [0.03%]
国际晶体学会生物大分子委员会在大阪举行的开放会议上将要讨论的衍射图像的提交
Edward Baker,Zbigniew Dauter,Mitchell Guss et al.
Edward Baker et al.
A forward-looking suggestion for resolving the stereochemical restraints debate: ideal geometry functions [0.03%]
展望立体化学约束争论的解决建议：理想几何函数
P Andrew Karplus,Maxim V Shapovalov,Roland L Dunbrack Jr et al.
P Andrew Karplus et al.
Structures of D-amino-acid amidase complexed with L-phenylalanine and with L-phenylalanine amide: insight into the D-stereospecificity of D-amino-acid amidase from Ochrobactrum anthropi SV3 [0.03%]
D-氨基酸氨酶与L-苯丙氨酸及L-苯甲酰胺的复合物结构：来源于SV3的人源 opportunistic 生丝状杆菌的D-氨基酸氨酶对D-立体异构体特异性的见解
Seiji Okazaki,Atsuo Suzuki,Tsunehiro Mizushima et al.
Seiji Okazaki et al.
The crystal structures of D-amino-acid amidase (DAA) from Ochrobactrum anthropi SV3 in complex with L-phenylalanine and with L-phenylalanine amide were determined at 2.3 and 2.2 A resolution, respectively. Comparison of the L-phenylalanine ...
The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae [0.03%]
一个冗余酶的结构：霍乱弧菌天冬氨酸β-半醛脱氢酶第二个同工酶的功能研究
Ronald E Viola,Xuying Liu,Jeffrey F Ohren et al.
Ronald E Viola et al.
Aspartate-beta-semialdehyde dehydrogenase (ASADH) is an essential enzyme that is found in bacteria, fungi and plants but not in humans. ASADH produces the first branch-point metabolite in the biosynthetic pathways that lead to the productio...