An investigation into the protonation states of the C1 domain of cardiac myosin-binding protein C [0.03%]
心肌联蛋白C1结构域质子化状态的研究
S J Fisher,J R Helliwell,S Khurshid et al.
S J Fisher et al.
Myosin-binding protein C (MyBP-C) is a myofibril-associated protein found in cardiac and skeletal muscle. The cardiac isoform (cMyBP-C) is subject to reversible phosphorylation and the surface-charge state of the protein is of keen interest...
Structure of human alpha-enolase (hENO1), a multifunctional glycolytic enzyme [0.03%]
人类α烯醇化酶（hENO1）的结构研究——一种多功能糖酵解酶
Hyo Jin Kang,Suk-Kyeong Jung,Seung Jun Kim et al.
Hyo Jin Kang et al.
Aside from its enzymatic function in the glycolytic pathway, alpha-enolase (ENO1) has been implicated in numerous diseases, including metastatic cancer, autoimmune disorders, ischaemia and bacterial infection. The disease-related roles of E...
Structural analysis of the L-alanoyl-D-glutamate endopeptidase domain of Listeria bacteriophage endolysin Ply500 reveals a new member of the LAS peptidase family [0.03%]
链球菌噬菌体溶菌酶Ply500的L-丙氨酰-D-谷氨酸内肽酶结构域的结构分析揭示了一个新的LAS肽酶家族成员
Ingo P Korndörfer,Alexander Kanitz,Josef Danzer et al.
Ingo P Korndörfer et al.
Similar to many other bacterial cell-wall-hydrolyzing enzymes, the Listeria bacteriophage A500 endopeptidase Ply500 has a modular architecture consisting of an enzymatically active domain (EAD) linked to a cell-wall-binding domain (CBD) in ...
Daniel Frey,Thomas Huber,Andreas Plückthun et al.
Daniel Frey et al.
The structure of the antibody Fab fragment f3p4, which was selected from a subset of the synthetic HuCAL antibody library to bind the sodium citrate symporter CitS, is described at 1.92 A resolution. Comparison with computational models rev...
The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis [0.03%]
来自结核分支杆菌的次黄嘌呤鸟嘌呤磷酸核糖转移酶的1.25埃分辨率晶体结构
Farah Javid-Majd,Dong Yang,Thomas R Ioerger et al.
Farah Javid-Majd et al.
Phosphoribosyl-ATP pyrophosphohydrolase is the second enzyme in the histidine-biosynthetic pathway, irreversibly hydrolyzing phosphoribosyl-ATP to phosphoribosyl-AMP and pyrophosphate. It is encoded by the hisE gene, which is present as a s...
Frantisek Pavelcik,Bohdan Schneider
Frantisek Pavelcik
A method has been developed that automatically fits double-helical regions into the electron density of nucleic acid structures. Rigid fragments consisting of two Watson-Crick base pairs and three pairs of phosphate groups in the A-type or ...
Talat Jabeen,Philip Leonard,Haryati Jamaluddin et al.
Talat Jabeen et al.
Interferon-gamma-inducible protein (IP-10) belongs to the CXC class of chemokines and plays a significant role in the pathophysiology of various immune and inflammatory responses. It is also a potent angiostatic factor with antifibrotic pro...
James F Parsons,Katherine M Shi,Jane E Ladner
James F Parsons
The electron carrier menaquinone is one of many important bacterial metabolites that are derived from the key intermediate chorismic acid. MenF, the first enzyme in the menaquinone pathway, catalyzes the isomerization of chorismate to isoch...
MAD phasing using the (Ta6Br12)2+ cluster: a retrospective study [0.03%]
利用(Ta6Br12)2+簇进行MAD相位测定的回顾性研究
Oliwia Pasternak,Anna Bujacz,Jacek Biesiadka et al.
Oliwia Pasternak et al.
The crystal structure of cytokinin-specific binding protein (CSBP) containing four independent molecules with 4 x 155 = 620 residues in the asymmetric unit of the P6(4) unit cell has been solved by three-wavelength MAD using 1.8 angstroms r...
Konstantin Popovic,Gilbert G Privé
Konstantin Popovic
Saposin D is a sphingolipid activator protein required for the lysosomal breakdown of ceramide to a fatty acid and sphingosine by acid ceramidase. The crystal structure of saposin D has been determined in two different crystal forms, result...