Structure determination of the 1918 H1N1 neuraminidase from a crystal with lattice-translocation defects [0.03%]
一个晶格迁移缺陷晶体中的1918年H1N1神经氨酸酶结构测定
Xueyong Zhu,Xiaojin Xu,Ian A Wilson
Xueyong Zhu
Few examples of macromolecular crystals containing lattice-translocation defects have been published in the literature. Lattice translocation and twinning are believed to be two common but different crystal-growth anomalies. While the succe...
Pattern-recognition-based detection of planar objects in three-dimensional electron-density maps [0.03%]
基于模式识别的三维电子密度图中平面对象检测方法
Johan Hattne,Victor S Lamzin
Johan Hattne
A pattern-recognition-based method for the detection of planar objects in protein or DNA/RNA crystal structure determination is described. The procedure derives a set of rotation-invariant numeric features from local regions in the asymmetr...
Improved classification of crystallization images using data fusion and multiple classifiers [0.03%]
基于数据融合和多种分类器的结晶图像分类方法研究
Samarasena Buchala,Julie C Wilson
Samarasena Buchala
Identifying the conditions that will produce diffraction-quality crystals can require very many crystallization experiments. The use of robots has increased the number of experiments performed in most laboratories, while in structural genom...
Ella Czarina Magat Juan,Md Mominul Hoque,Satoru Shimizu et al.
Ella Czarina Magat Juan et al.
The enzyme urate oxidase catalyzes the conversion of uric acid to 5-hydroxyisourate, one of the steps in the ureide pathway. Arthrobacter globiformis urate oxidase (AgUOX) was crystallized and structures of crystals soaked in the substrate ...
Steve Androulakis,Jason Schmidberger,Mark A Bate et al.
Steve Androulakis et al.
There is a pressing need for the archiving and curation of raw X-ray diffraction data. This information is critical for validation, methods development and improvement of archived structures. However, the relatively large size of these data...
1.6 angstroms structure of an NAD+-dependent quinate dehydrogenase from Corynebacterium glutamicum [0.03%]
来自大谷氨酸菌的烟酰胺腺嘌呤二核苷酸依赖性的莽草酸脱氢酶的1.6埃结构
Jan Schoepe,Karsten Niefind,Dietmar Schomburg
Jan Schoepe
To date, three different functional classes of bacterial shikimate/quinate dehydrogenases have been identified and are referred to as AroE, SDH-L and YdiB. The enzyme AroE and the catalytically much slower SDH-L clearly prefer NADP+/NADPH a...
Structure determination of an anti-HIV-1 Fab 447-52D-peptide complex from an epitaxially twinned data set [0.03%]
由表征孪晶数据集确定抗HIV-1抗体Fab 447-52D-肽复合物的结构
Amandeep K Dhillon,Robyn L Stanfield,Miroslaw K Gorny et al.
Amandeep K Dhillon et al.
Although antibodies against the third variable loop (V3) of the HIV-1 viral envelope glycoprotein are among the first neutralizing antibodies to be detected in infected individuals, they are normally restricted in their specificity. X-ray c...
Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid) [0.03%]
人消化蛋白酶与粘膜黏附聚丙烯酸的直接相互作用
Irantzu Pallarès,Daniel Fernández,Mireia Comellas-Bigler et al.
Irantzu Pallarès et al.
Carboxypeptidase A1 has been the subject of extensive research in the last 30 y and is one of the most widely studied zinc metalloenzymes. However, the three-dimensional structure of the human form of the enzyme is not yet available. This r...
On the determinants of amide backbone exchange in proteins: a neutron crystallographic comparative study [0.03%]
蛋白质酰胺主链交换的决定因素：中子晶体学比较研究
Brad C Bennett,Anna S Gardberg,Matthew D Blair et al.
Brad C Bennett et al.
The hydrogen/deuterium-exchange (HDX) method, coupled with neutron diffraction, is a powerful probe for investigating molecular dynamics. In the present report, general determinants of HDX are proposed based on 12 deposited neutron protein ...
High-resolution structure of unbound human immunodeficiency virus 1 subtype C protease: implications of flap dynamics and drug resistance [0.03%]
高分辨率未结合人免疫缺陷病毒1型C亚型蛋白酶结构：翅片动力学和药物耐药性的意义
Roxana M Coman,Arthur H Robbins,Maureen M Goodenow et al.
Roxana M Coman et al.
The X-ray crystal structure of the unbound state of human immunodeficiency virus 1 (HIV-1) subtype C protease (C PR) has been determined to 1.20 angstroms resolution in the tetragonal space group P4(1)2(1)2, with one monomer per asymmetric ...