Lydia M Gibson,Nin N Dingra,Caryn E Outten et al.
Lydia M Gibson et al.
Yeast glutaredoxin 3 (Grx3) is a cytosolic protein that regulates the activity of the iron-responsive transcriptional activator Aft1. This member of the monothiol glutaredoxin family contains a thioredoxin-like domain and a glutaredoxin-lik...
Crystal packing of the c(6)-type cytochrome OmcF from Geobacter sulfurreducens is mediated by an N-terminal Strep-tag II [0.03%]
产硫脱硫弧菌的c(6)型细胞色素OmcF晶体堆积由N端Strep标签II介导
Peer Lukat,Maren Hoffmann,Oliver Einsle
Peer Lukat
The putative outer membrane c-type cytochrome OmcF from Geobacter sulfurreducens contains a single haem group and shows homology to soluble cytochromes c(6), a class of electron-transfer proteins that are typically found in cyanobacterial p...
Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands [0.03%]
斑马鱼极光蛋白激酶1（Plk1）野生型和活性结构：活性位点构象的变化及与配体的相互作用
Robert A Elling,Raymond V Fucini,Michael J Romanowski
Robert A Elling
Polo-like kinase 1 (Plk1) is a member of a family of serine/threonine kinases involved in the regulation of cell-cycle progression and cytokinesis and is an attractive target for the development of anticancer therapeutics. A zebrafish homol...
Coulombic and dispersive factors in the molecular recognition of peptides: PIXEL calculations on two NNQQ (Asn-Asn-Gln-Gln) crystal polymorphs [0.03%]
肽分子识别中的库仑和色散因素：二种NNQQ（天冬氨酰-天冬氨酰-谷氨酰-谷氨酰）晶型的PIXEL计算
Angelo Gavezzotti
Angelo Gavezzotti
The crystal-packing and cohesive energies in the structures of two polymorphs of the title tetrapeptide have been analyzed using molecule-molecule energies calculated using the PIXEL method. Coulombic energies are non-empirical and are much...
Ronald E Stenkamp
Ronald E Stenkamp
The space-group symmetry of two crystal forms of rhodopsin (PDB codes 1gzm and 2j4y; space group P3(1)) can be re-interpreted as hexagonal (space group P6(4)). Two molecules of the G protein-coupled receptor are present in the asymmetric un...
Structure of a superoxide dismutase and implications for copper-ion chelation [0.03%]
超氧化物歧化酶的结构及铜离子螯合的意义
Manickam Yogavel,Prakash Chandra Mishra,Jasmita Gill et al.
Manickam Yogavel et al.
Superoxide dismutase (SOD) plays a central role in cellular defence against oxidative stress and is of pharmaceutical importance. The SOD from Potentilla atrosanguinea (Pa-SOD) is a unique enzyme as it possesses free-radical scavenging capa...
Structural evidence for the inhibition of grape dihydroflavonol 4-reductase by flavonols [0.03%]
flavones抑制葡萄脱氢黄酮醇-4-还原酶的结构证据
Nadia Trabelsi,Pierre Petit,Claude Manigand et al.
Nadia Trabelsi et al.
Dihydroflavonol 4-reductase (DFR) is a key enzyme of the flavonoid biosynthesis pathway which catalyses the NADPH-dependent reduction of 2R,3R-trans-dihydroflavonols to leucoanthocyanidins. The latter are the precursors of anthocyans and co...
Catherine L Lawson,Shuchismita Dutta,John D Westbrook et al.
Catherine L Lawson et al.
A new scheme has been devised to represent viruses and other biological assemblies with regular noncrystallographic symmetry in the Protein Data Bank (PDB). The scheme describes existing and anticipated PDB entries of this type using genera...
Christian Dumas,Arie van der Lee
Christian Dumas
The recently discovered charge-flipping phasing algorithm has received growing interest in small-molecule crystallography and powder diffraction. This computational methodology differs from classical direct methods as it does not require a ...
Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase [0.03%]
蛋白质中短强氢键的实例研究：鼠李半乳糖醛酸聚糖乙酰酯酶中的氢键分析
Annette Langkilde,Søren M Kristensen,Leila Lo Leggio et al.
Annette Langkilde et al.
An extremely low-field signal (at approximately 18 p.p.m.) in the (1)H NMR spectrum of rhamnogalacturonan acetylesterase (RGAE) shows the presence of a short strong hydrogen bond in the structure. This signal was also present in the mutant ...