Structure of the Bacillus subtilis OhrB hydroperoxide-resistance protein in a fully oxidized state [0.03%]
完全氧化形式的枯草芽孢杆菌OhrB羟基过氧化物抗性蛋白结构
David R Cooper,Yogesh Surendranath,Yancho Devedjiev et al.
David R Cooper et al.
The crystal structure of the fully oxidized form of the Bacillus subtilis organic hydroperoxide-resistance (OhrB) protein is reported at 2.1 A resolution. The electron density reveals an intact catalytic disulfide bond (Cys55-Cys119) in eac...
Jiawei Wang,Miroslawa Dauter,Randy Alkire et al.
Jiawei Wang et al.
The crystal structure of triclinic hen egg-white lysozyme (HEWL) has been refined against diffraction data extending to 0.65 A resolution measured at 100 K using synchrotron radiation. Refinement with anisotropic displacement parameters and...
Comparison of two T-state structures of regulatory-chain mutants of Escherichia coli aspartate transcarbamoylase suggests that His20 and Asp19 modulate the response to heterotropic effectors [0.03%]
比较大肠杆菌天冬氨酸氨基甲酸转移酶调控链突变体的两种T态结构表明组氨酸20和天门冬氨酸19能调节非底物效应物的作用
Boguslaw Stec,Mark K Williams,Kimberly A Stieglitz et al.
Boguslaw Stec et al.
Asp19 and His20 of Escherichia coli aspartate transcarbamoylase (EC 2.1.3.2) function in the binding of the triphosphate and ribose moieties of ATP and CTP and thereby may mediate important heterotropic regulation. The roles of these residu...
On the interrelationship between atomic displacement parameters (ADPs) and coordinates in protein structures [0.03%]
论蛋白质结构中原子位移参数（ADP）与坐标之间的相互关系
Manfred S Weiss
Manfred S Weiss
Macromolecular models refined against X-ray diffraction data are typically described by a set of atomic coordinates and atomic displacement parameters (ADPs). Although it is intuitively obvious that the two cannot be independent of each oth...
Structure of the human Tim44 C-terminal domain in complex with pentaethylene glycol: ligand-bound form [0.03%]
人Tim44羧基末端结构域与五乙二醇复合物的晶体结构：配体结合形式
Noriko Handa,Seiichiro Kishishita,Satoshi Morita et al.
Noriko Handa et al.
Familial oncocytic thyroid carcinoma is associated with a missense mutation, P308Q, in the C-terminal domain of Tim44. Tim44 is the mitochondrial inner-membrane translocase subunit and it functions as a membrane anchor for the mitochondrial...
Structure of the branched-chain keto acid decarboxylase (KdcA) from Lactococcus lactis provides insights into the structural basis for the chemoselective and enantioselective carboligation reaction [0.03%]
乳酸链球菌支链酮酸脱羧酶（KdcA）结构为化学选择性和对映选择性碳连接反应的结构基础提供见解
Catrine L Berthold,Dörte Gocke,Martin D Wood et al.
Catrine L Berthold et al.
The thiamin diphosphate (ThDP) dependent branched-chain keto acid decarboxylase (KdcA) from Lactococcus lactis catalyzes the decarboxylation of 3-methyl-2-oxobutanoic acid to 3-methylpropanal (isobutyraldehyde) and CO2. The enzyme is also a...
Structure-assisted discovery of an aminothiazole derivative as a lead molecule for inhibition of bacterial fatty-acid synthesis [0.03%]
基于结构的发现：一种氨基噻唑衍生物可作为抑制细菌脂肪酸合成的先导化合物
Günter Pappenberger,Tanja Schulz-Gasch,Eric Kusznir et al.
Günter Pappenberger et al.
Fatty-acid synthesis in bacteria is of great interest as a target for the discovery of antibacterial compounds. The addition of a new acetyl moiety to the growing fatty-acid chain, an essential step in this process, is catalyzed by beta-ket...
Erika V Soriano,Valerie C Clark,Steven E Ealick
Erika V Soriano
Human deoxycytidine kinase (dCK) is involved in the nucleotide-biosynthesis salvage pathway and has also been shown to phosphorylate several antitumor and antiviral prodrugs. The structures of dCK alone and the dead-end complex of dCK with ...
Interaction between the androgen receptor and a segment of its corepressor SHP [0.03%]
雄激素受体与它的核心pressorSHP一段的相互作用
Natalia Jouravel,Elena Sablin,Leggy A Arnold et al.
Natalia Jouravel et al.
The mechanisms of functional repression of the androgen receptor (AR) are crucial for the regulation of genes involved in physiological development as well as for the progression of prostate cancer. To date, only two in vivo inhibitors of A...
On macromolecular refinement at subatomic resolution with interatomic scatterers [0.03%]
基于原子间散射的亚原子分辨率大分子细化方法
Pavel V Afonine,Ralf W Grosse-Kunstleve,Paul D Adams et al.
Pavel V Afonine et al.
A study of the accurate electron-density distribution in molecular crystals at subatomic resolution (better than approximately 1.0 A) requires more detailed models than those based on independent spherical atoms. A tool that is conventional...