Gül Dölen,Emily Osterweil,B S Shankaranarayana Rao et al.
Gül Dölen et al.
Fragile X syndrome (FXS) is the most common form of heritable mental retardation and the leading identified cause of autism. FXS is caused by transcriptional silencing of the FMR1 gene that encodes the fragile X mental retardation protein (...
Stephen R Williams,Christian Wozny,Simon J Mitchell
Stephen R Williams
Synapses are located throughout the often-elaborate dendritic tree of central neurons. Hebbian models of plasticity require temporal association between synaptic input and neuronal output to produce long-term potentiation of excitatory tran...
Jozsef Vigh,Henrique von Gersdorff
Jozsef Vigh
Endocannabinoids are generally known to suppress excitatory or inhibitory synaptic transmission. Now, in an elegant series of experiments, Cachope et al. reveal a novel signaling pathway whereby endocannabinoids indirectly potentiate mixed ...
Pumping up the synapse [0.03%]
强化突触效应
Peter Penzes
Peter Penzes
Synchronized control of excitatory and inhibitory synapse maturation is crucial for normal brain wiring, while its dysfunction leads to neurodevelopmental disorders, including autism. A paper in this issue of Neuron identified a novel role ...
George Zanazzi,Gary Matthews
George Zanazzi
Synaptojanin1 degrades the signaling lipid phosphatidylinositol-4,5-bisphosphate and facilitates compensatory endocytosis, clathrin-coat disassembly, and vesicle reavailability at active synapses. In this issue of Neuron, Mani et al. provid...
A crystal-clear interaction: relating neuroligin/neurexin complex structure to function at the synapse [0.03%]
晶莹剔透的互动：神经突触中神经粘素/神经蛋白xin复合物结构与功能的关系
Joshua N Levinson,Alaa El-Husseini
Joshua N Levinson
Neuronal circuits are maintained by homeostatic mechanisms controlling synapse maturation and signaling. Neuroligins (NLs) and neurexins (Nrxs) may regulate the fine balance between excitation and inhibition. In this issue of Neuron, Araç ...
Jessica R Andrews-Hanna,Abraham Z Snyder,Justin L Vincent et al.
Jessica R Andrews-Hanna et al.
Cognitive decline is commonly observed in advanced aging even in the absence of disease. Here we explore the possibility that normal aging is accompanied by disruptive alterations in the coordination of large-scale brain systems that suppor...
Spatiotemporal dynamics of cortical sensorimotor integration in behaving mice [0.03%]
在行为小鼠中皮层感觉运动整合的时空动态变化规律
Isabelle Ferezou,Florent Haiss,Luc J Gentet et al.
Isabelle Ferezou et al.
Tactile information is actively acquired and processed in the brain through concerted interactions between movement and sensation. Somatosensory input is often the result of self-generated movement during the active touch of objects, and co...
Nevena Milenkovic,Christina Frahm,Max Gassmann et al.
Nevena Milenkovic et al.
The molecular mechanisms regulating the sensitivity of sensory circuits to environmental stimuli are poorly understood. We demonstrate here a central role for stem cell factor (SCF) and its receptor, c-Kit, in tuning the responsiveness of s...
Noradrenaline modulates transmission at a central synapse by a presynaptic mechanism [0.03%]
去甲肾上腺素通过一个突触前机制调节中枢突触的传递作用
Andrew J Delaney,James W Crane,Pankaj Sah
Andrew J Delaney
The lateral division of the central amygdala (CeAL) is the target of ascending fibers from the pain-responsive and stress-responsive nuclei in the brainstem. We show that single fiber inputs from the nociceptive pontine parabrachial nucleus...