Calcium channel modulation as an all-purpose mechanism for short-term synaptic plasticity [0.03%]
钙通道调节作为短期突触可塑性的通用机制
Qing Cheng,George J Augustine
Qing Cheng
The paper by Mochida et al. in this issue of Neuron proposes that synaptic facilitation, depression, and augmentation all arise from calcium-dependent regulation of calcium channels in the presynaptic terminal. Their proposal provides a uni...
Mesmerizing memories: brain substrates of episodic memory suppression in posthypnotic amnesia [0.03%]
催眠遗忘症情景记忆抑制的脑机制研究
Avi Mendelsohn,Yossi Chalamish,Alexander Solomonovich et al.
Avi Mendelsohn et al.
Two groups of participants, one susceptible to posthypnotic amnesia (PHA) and the other not, viewed a movie. A week later, they underwent hypnosis in the fMRI scanner and received a suggestion to forget the movie details after hypnosis unti...
Adaptation to natural binocular disparities in primate V1 explained by a generalized energy model [0.03%]
灵长类V1的自然双眼视差适应可以通过广义能量模型来解释
Ralf M Haefner,Bruce G Cumming
Ralf M Haefner
Sensory processing in the brain is thought to have evolved to encode naturally occurring stimuli efficiently. We report an adaptation in binocular cortical neurons that reflects the tight constraints imposed by the geometry of 3D vision. We...
Origin and dynamics of extraclassical suppression in the lateral geniculate nucleus of the macaque monkey [0.03%]
猕猴外侧膝状核中非经典抑制的起源与动态
Henry J Alitto,W Martin Usrey
Henry J Alitto
In addition to the classical, center/surround receptive field of neurons in the lateral geniculate nucleus (LGN), there is an extraclassical, nonlinear surround that can strongly suppress LGN responses. This form of suppression likely plays...
Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses [0.03%]
腺苷A2A受体对海马苔藓纤维突触NMDA-EPSC的长期增强是必不可少的
Nelson Rebola,Rafael Lujan,Rodrigo A Cunha et al.
Nelson Rebola et al.
The physiological conditions under which adenosine A2A receptors modulate synaptic transmission are presently unclear. We show that A2A receptors are localized postsynaptically at synapses between mossy fibers and CA3 pyramidal cells and ar...
Long-term potentiation selectively expressed by NMDA receptors at hippocampal mossy fiber synapses [0.03%]
NMDA受体在海马 mossy纤维突触上选择性地表达长期增强作用
Hyung-Bae Kwon,Pablo E Castillo
Hyung-Bae Kwon
The mossy fiber to CA3 pyramidal cell synapse (mf-CA3) provides a major source of excitation to the hippocampus. Thus far, these glutamatergic synapses are well recognized for showing a presynaptic, NMDA receptor-independent form of LTP tha...
Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex [0.03%]
钙调素激酶信号复合体通过调节PIXbeta调控活动依赖性突触发生
Takeo Saneyoshi,Gary Wayman,Dale Fortin et al.
Takeo Saneyoshi et al.
Neuronal activity augments maturation of mushroom-shaped spines to form excitatory synapses, thereby strengthening synaptic transmission. We have delineated a Ca(2+)-signaling pathway downstream of the NMDA receptor that stimulates calmodul...
Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition [0.03%]
别构抑制作用下的NR1/NR2A型N-甲基-D天冬氨酸受体结构重组
Marc Gielen,Anne Le Goff,David Stroebel et al.
Marc Gielen et al.
Ionotropic glutamate receptor (iGluR) subunits contain a large N-terminal domain (NTD) that precedes the agonist-binding domain (ABD) and participates in subunit oligomerization. In NMDA receptors (NMDARs), the NTDs of NR2A and NR2B subunit...
Cell-nonautonomous function of ceramidase in photoreceptor homeostasis [0.03%]
视杆细胞溶血磷脂酶Smartd的非自主功能在光感受器稳态中的作用
Jairaj K Acharya,Ujjaini Dasgupta,Satinder S Rawat et al.
Jairaj K Acharya et al.
Neutral ceramidase, a key enzyme of sphingolipid metabolism, hydrolyzes ceramide to sphingosine. These sphingolipids are critical structural components of cell membranes and act as second messengers in diverse signal transduction cascades. ...
The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C [0.03%]
SOCS框蛋白STOPS通过其对磷脂酶C的作用来参与光转导路径
Tao Wang,Xiaoyue Wang,Qiang Xie et al.
Tao Wang et al.
Phosphoinositide-specific phospholipase C (PLC) isozymes play roles in a diversity of processes including Drosophila phototransduction. In fly photoreceptor cells, the PLCbeta encoded by norpA is critical for activation of TRP channels. Her...