Widespread inhibition proportional to excitation controls the gain of a leech behavioral circuit [0.03%]
抑制与兴奋呈比例的广泛存在控制了水蛭行为电路的增益现象
Serapio M Baca,Antonia Marin-Burgin,Daniel A Wagenaar et al.
Serapio M Baca et al.
Changing gain in a neuronal system has important functional consequences, but the underlying mechanisms have been elusive. Models have suggested a variety of neuronal and systems properties to accomplish gain control. Here, we show that the...
Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3 [0.03%]
缺乏囊泡谷氨酸转运体3的小鼠的神经感觉聋和惊厥
Rebecca P Seal,Omar Akil,Eunyoung Yi et al.
Rebecca P Seal et al.
The expression of unconventional vesicular glutamate transporter VGLUT3 by neurons known to release a different classical transmitter has suggested novel roles for signaling by glutamate, but this distribution has raised questions about whe...
Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD [0.03%]
Postsynaptic密度蛋白PSD-95在调节突触效能和长时程抑制方面的分子解离作用
Weifeng Xu,Oliver M Schlüter,Pascal Steiner et al.
Weifeng Xu et al.
The postsynaptic density protein PSD-95 influences synaptic AMPA receptor (AMPAR) content and may play a critical role in LTD. Here we demonstrate that the effects of PSD-95 on AMPAR-mediated synaptic responses and LTD can be dissociated. O...
SOX5 controls the sequential generation of distinct corticofugal neuron subtypes [0.03%]
SOX5控制不同的皮层脊髓神经元亚型的顺序产生
Tina Lai,Denis Jabaudon,Bradley J Molyneaux et al.
Tina Lai et al.
The molecular mechanisms controlling the development of distinct subtypes of neocortical projection neurons, and CNS neuronal diversity more broadly, are only now emerging. We report that the transcription factor SOX5 controls the sequentia...
Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity [0.03%]
Nkx6.1活性的后有丝分裂限制确定了早期运动神经元池的身份和肌肉神经轨迹
Natalia V De Marco Garcia,Thomas M Jessell
Natalia V De Marco Garcia
The fidelity with which spinal motor neurons innervate their limb target muscles helps to coordinate motor behavior, but the mechanisms that determine precise patterns of nerve-muscle connectivity remain obscure. We show that Nkx6 proteins,...
Regulation of presynaptic Ca(V)2.1 channels by Ca2+ sensor proteins mediates short-term synaptic plasticity [0.03%]
钙2+传感器蛋白对前突触Ca(V)2.1通道的调节介导短期突触可塑性
Sumiko Mochida,Alexandra P Few,Todd Scheuer et al.
Sumiko Mochida et al.
Short-term synaptic plasticity shapes the postsynaptic response to bursts of impulses and is crucial for encoding information in neurons, but the molecular mechanisms are unknown. Here we show that activity-dependent modulation of presynapt...
Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression [0.03%]
药物转运基因ABCB1多态性预测抑郁障碍抗抑郁药治疗反应研究
Manfred Uhr,Alina Tontsch,Christian Namendorf et al.
Manfred Uhr et al.
The clinical efficacy of a systemically administered drug acting on the central nervous system depends on its ability to pass the blood-brain barrier, which is regulated by transporter molecules such as ABCB1 (MDR1). Here we report that pol...
Clinical Trial
Neuron. 2008 Jan 24;57(2):203-9. DOI:10.1016/j.neuron.2007.11.017 2008
The blood-brain barrier in health and chronic neurodegenerative disorders [0.03%]
屏障护脑：屏障在健康和慢性神经退行性疾病中的作用
Berislav V Zlokovic
Berislav V Zlokovic
The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the BBB separates components of the circulating blood ...
Susumu Tonegawa,Thomas J McHugh
Susumu Tonegawa
The anatomy of the entorhinal-hippocampal circuit suggests how spatial information may flow into and out of the CA1 region. In this issue of Neuron, two groups use in vivo physiology to make predictions about the circuit mechanisms involved...
Gudrun Ahnert-Hilger,Reinhard Jahn
Gudrun Ahnert-Hilger
The vesicular glutamate transporters VGLUT1 and VGLUT2 fill synaptic vesicles with glutamate, an essential prerequisite for glutamatergic transmission in the CNS. In contrast, the third isoform, VGLUT3, is not confined to glutamatergic neur...