Satb2 regulates callosal projection neuron identity in the developing cerebral cortex [0.03%]
Satb2调控发育皮层胼胝体投射神经元的身份属性
Elizabeth A Alcamo,Laura Chirivella,Marcel Dautzenberg et al.
Elizabeth A Alcamo et al.
Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, ...
GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems [0.03%]
利用GFP重组跨突触配对技术（GRASP）界定活体神经系统的细胞连接及突触联系
Evan H Feinberg,Miri K Vanhoven,Andres Bendesky et al.
Evan H Feinberg et al.
The identification of synaptic partners is challenging in dense nerve bundles, where many processes occupy regions beneath the resolution of conventional light microscopy. To address this difficulty, we have developed GRASP, a system to lab...
Baron Chanda,Francisco Bezanilla
Baron Chanda
Voltage-gated ion channels derive their voltage sensitivity from the movement of specific charged residues in response to a change in transmembrane potential. Several studies on mechanisms of voltage sensing in ion channels support the idea...
Tudor A Fulga,David Van Vactor
Tudor A Fulga
The formation of the nervous system during embryonic development is controlled by a complex network of signaling pathways which ensure proper migration and targeting of neuronal projections. Likewise, the function of the adult nervous syste...
Gord Fishell,Carina Hanashima
Gord Fishell
The precise stereotypic projections of pyramidal neurons within the six-layered cortex of mammals are key in allowing this structure to attain its high level of function. Recent studies have provided the first indications that postmitotic t...
Chris D Frith,Uta Frith
Chris D Frith
In this issue of Neuron, a study by Chiu et al. examines the brain responses of autistic volunteers in a trust game. The findings reveal an unusual lack of brain activity in mid cingulate cortex when they make their investments. We speculat...
Balancing between adaptive and maladaptive cellular stress responses in peripheral neuropathy [0.03%]
外周神经病理性疼痛中适应性与非适应性细胞应激反应的平衡
Mehrdad Khajavi,James R Lupski
Mehrdad Khajavi
Point mutations in "myelin genes" result in a spectrum of inherited demyelinating neuropathies. The understanding of the pathomechanisms by which these mutations produce phenotypes remains limited. In this issue of Neuron, Wrabetz and colle...
René Quilodran,Marie Rothé,Emmanuel Procyk
René Quilodran
Rapid optimization of behavior requires decisions about when to explore and when to exploit discovered resources. The mechanisms that lead to fast adaptations and their interaction with action valuation are a central issue. We show here tha...
Sen Cheng,Loren M Frank
Sen Cheng
The acquisition of new memories for places and events requires synaptic plasticity in the hippocampus, and plasticity depends on temporal coordination among neurons. Spatial activity in the hippocampus is relatively disorganized during the ...
Impaired spatial representation in CA1 after lesion of direct input from entorhinal cortex [0.03%]
内嗅皮层直接输入至CA1的损伤导致空间表征障碍
Vegard Heimly Brun,Stefan Leutgeb,Hui-Qiu Wu et al.
Vegard Heimly Brun et al.
Place-specific firing in the hippocampus is determined by path integration-based spatial representations in the grid-cell network of the medial entorhinal cortex. Output from this network is conveyed directly to CA1 of the hippocampus by pr...