Medha M Pathak,Vladimir Yarov-Yarovoy,Gautam Agarwal et al.
Medha M Pathak et al.
Membrane depolarization causes voltage-gated ion channels to transition from a resting/closed conformation to an activated/open conformation. We used voltage-clamp fluorometry to measure protein motion at specific regions of the Shaker Kv c...
The BMP ligand Gbb gates the expression of synaptic homeostasis independent of synaptic growth control [0.03%]
Gbb作为BMP配体调控突触稳态独立于其调节突触生长的功能
Carleton P Goold,Graeme W Davis
Carleton P Goold
Inhibition of postsynaptic glutamate receptors at the Drosophila NMJ initiates a compensatory increase in presynaptic release termed synaptic homeostasis. BMP signaling is necessary for normal synaptic growth and stability. It remains unkno...
Regulation of dendritic development by neuron-specific chromatin remodeling complexes [0.03%]
染色质重塑复合体在神经元树突发育中的作用
Jiang I Wu,Julie Lessard,Ivan A Olave et al.
Jiang I Wu et al.
The diversity of dendritic patterns is one of the fundamental characteristics of neurons and is in part regulated by transcriptional programs initiated by electrical activity. We show that dendritic outgrowth requires a family of combinator...
Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool [0.03%]
Cep120和TACCs调控间期核迁移及神经前体细胞群大小
Zhigang Xie,Lily Y Moy,Kamon Sanada et al.
Zhigang Xie et al.
Centrosome- and microtubule-associated proteins have been shown to be important for maintaining the neural progenitor pool during neocortical development by regulating the mitotic spindle. It remains unclear whether these proteins may contr...
Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1 [0.03%]
淀粉样前体蛋白通过脂蛋白受体LRP1调节脑内载脂蛋白E和胆固醇代谢
Qiang Liu,Celina V Zerbinatti,Juan Zhang et al.
Qiang Liu et al.
Mutations in the amyloid precursor protein (APP) cause early-onset Alzheimer's disease (AD), but the only genetic risk factor for late-onset AD is the varepsilon4 allele of apolipoprotein E (apoE), a major cholesterol carrier. Using Cre-lox...
MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number [0.03%]
MeCP2通过调节谷氨酸能突触数量控制兴奋性突触强度
Hsiao-Tuan Chao,Huda Y Zoghbi,Christian Rosenmund
Hsiao-Tuan Chao
MeCP2 is a transcriptional repressor critical for normal neurological function. Prior studies demonstrated that either loss or doubling of MeCP2 results in postnatal neurodevelopmental disorders. To understand the impact of MeCP2 expression...
Imaging large-scale neural activity with cellular resolution in awake, mobile mice [0.03%]
在清醒、活动的小鼠中以细胞分辨率成像大脑的大型神经网络
Daniel A Dombeck,Anton N Khabbaz,Forrest Collman et al.
Daniel A Dombeck et al.
We report a technique for two-photon fluorescence imaging with cellular resolution in awake, behaving mice with minimal motion artifact. The apparatus combines an upright, table-mounted two-photon microscope with a spherical treadmill consi...
Perisomatic inhibition [0.03%]
周边抑制
Tamás F Freund,István Katona
Tamás F Freund
Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition in the cerebral cortex: the parvalbumin- and cholecystokinin-containing basket cells that are specialized to control rhythm (as a clockwork) and "mo...
Response variation following trauma: a translational neuroscience approach to understanding PTSD [0.03%]
创伤后的应激障碍反应变化：一种神经科学研究方法
Rachel Yehuda,Joseph LeDoux
Rachel Yehuda
Exposure to traumatic stress is a requirement for the development of posttraumatic stress disorder (PTSD). However, because the majority of trauma-exposed persons do not develop PTSD, examination of the typical effects of a stressor will no...
P Read Montague,Terry Lohrenz
P Read Montague
Compliance with social norms requires neural signals related both to the norm and to deviations from it. Recent work using economic games between two interacting subjects has uncovered brain responses related to norm compliance and to an in...