Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons [0.03%]
Sez-6蛋白影响皮层锥体神经元的树突形态和兴奋性
Jenny M Gunnersen,Mary H Kim,Stephanie J Fuller et al.
Jenny M Gunnersen et al.
Development of appropriate dendritic arbors is crucial for neuronal information transfer. We show, using seizure-related gene 6 (sez-6) null mutant mice, that Sez-6 is required for normal dendritic arborization of cortical neurons. Deep-lay...
The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics [0.03%]
泛素连接酶Phr1通过调节微管动力学调控轴突生长
Joseph W Lewcock,Nicolas Genoud,Karen Lettieri et al.
Joseph W Lewcock et al.
To discover new genes involved in axon navigation, we conducted a forward genetic screen for recessive alleles affecting motor neuron pathfinding in GFP reporter mice mutagenized with ENU. In Magellan mutant embryos, motor axons were error ...
Nonapical symmetric divisions underlie horizontal cell layer formation in the developing retina in vivo [0.03%]
在活体中视网膜发育过程中非顶点对称分裂促进水平细胞层形成
Leanne Godinho,Philip R Williams,Yvonne Claassen et al.
Leanne Godinho et al.
Symmetric cell divisions have been proposed to rapidly increase neuronal number late in neurogenesis, but how critical this mode of division is to establishing a specific neuronal layer is unknown. Using in vivo time-lapse imaging methods, ...
Sang Jeong Kim,David J Linden
Sang Jeong Kim
To date, most hypotheses of memory storage in the mammalian brain have focused upon long-term synaptic potentiation and depression (LTP and LTD) of fast glutamatergic excitatory postsynaptic currents (EPSCs). In recent years, it has become ...
Sorting out sound [0.03%]
声音分类
Timothy D Griffiths
Timothy D Griffiths
Speech analysis is a prototypical categorical mechanism that has been examined behaviorally in work going back to Haskins Laboratory studies in the 1950s: such work examined the perception of continua between phonemes and demonstrated sharp...
When outgoing and incoming signals meet: new insights from the zona incerta [0.03%]
出入信号汇集之处：来自zona incerta的新见解
Mathew E Diamond,Ehud Ahissar
Mathew E Diamond
In the sense of touch, it is the motion of the sensory receptors themselves that leads to an afferent signal-whether these receptors are in our fingertips sliding along a surface or a rat's whiskers palpating an object. Afferent signals can...
Expanding neuronal layers by the local division of committed precursors [0.03%]
通过已分化的神经元前体局部分裂来增加神经元
Michel Cayouette
Michel Cayouette
A general strategy in vertebrate neural development is for neuronal precursors to stop dividing, to begin to differentiate, and then to migrate to their final destination. In this issue of Neuron, however, Godhino et al. provide evidence th...
Bevil R Conway,Sebastian Moeller,Doris Y Tsao
Bevil R Conway
Imaging studies are consistent with the existence of brain regions specialized for color, but electrophysiological studies have produced conflicting results. Here we address the neural basis for color, using targeted single-unit recording i...
He Cui,Richard A Andersen
He Cui
The posterior parietal cortex (PPC) of rhesus monkeys has been found to encode the behavioral meaning of categories of sensory stimuli. When animals are instructed with sensory cues to make either eye or hand movements to a target, PPC cell...
Robert J Schafer,Tirin Moore
Robert J Schafer
While the motor and attentional roles of the frontal eye field (FEF) are well documented, the relationship between them is unknown. We exploited the known influence of visual motion on the apparent positions of targets, and measured how thi...