T Cell Receptor-Engaging Monoclonal Antibodies Mobilize the Anti-Tumor Functions of Invariant Natural Killer T Cells [0.03%]
T细胞受体结合的单克隆抗体调动不变自然杀伤T细胞的抗肿瘤功能
Rupali Das
Rupali Das
Invariant natural killer T cells (iNKTs) are innate-type T lymphocytes that directly kill tumor cells or tumor-growth promoting immunosuppressive cells such astumor-associated macrophages. Additionally, iNKTs robustly transactivate the anti...
Role of Natural Killer T (NKT) Cells in Myeloma Biology and Therapy [0.03%]
天然杀伤T（NKT）细胞在多发性骨髓瘤的生物学和治疗中的作用
Madhav V Dhodapkar
Madhav V Dhodapkar
Natural Killer T (NKT) cells are distinct innate lymphocytes that recognize lipid antigens in the context of nonpolymorphic molecule CD1d. Multiple myeloma (MM) is a hematologic malignancy wherein malignant plasma cells express CD1d and are...
NKT-Licensed In Vivo Dendritic Cell-Based Immunotherapy as Cellular Immunodrugs for Cancer Treatment [0.03%]
用于癌症治疗的NKT许可的以树突细胞为基础的免疫疗法作为细胞性免疫药
Shin-Ichiro Fujii,Kanako Shimizu
Shin-Ichiro Fujii
With the advent of new therapies, immunotherapy has gained attention as a critical modality. After the discovery of the natural killer T (NKT) cells ligand, ex vivo cultured dendritic cells (DCs) loaded with NKT ligand (especially α-galact...
Recruiting Natural Killer T Cells to Improve Vaccination: Lessons from Preclinical and Clinical Studies [0.03%]
利用自然杀伤T细胞改善疫苗接种：来自临床前和临床研究的启示
Olivia K Burn,Nathaniel Dasyam,Ian F Hermans
Olivia K Burn
The capacity of type I natural killer T (NKT) cells to provide stimulatory signals to antigen-presenting cells has prompted preclinical research into the use of agonists as immune adjuvants, with much of this work focussed on stimulating T ...
Benjamin J Compton,Gavin F Painter
Benjamin J Compton
Natural killer T (NKT) cells are a population of innate-like T cells capable of enhancing both innate and adaptive immune responses. Co-delivering an NKT cell agonist and antigen can provide molecular signals to antigen-presenting cells, su...
Progress in Natural Killer T Cell-Based Immunotherapy for Cancer: Use of Allogeneic and Gene-Edited Cells [0.03%]
基于自然杀伤T细胞的癌症免疫疗法进展：同种异体和基因编辑细胞的使用
Takahiro Aoki,Shinichiro Motohashi
Takahiro Aoki
Immune cell therapy has received attention in the clinical setting. However, current chimeric antigen receptor T cell therapies require individualized manufacturing based on patient cells, resulting in high costs and long processing times. ...
Masaki Terabe,Vipin Kumar
Masaki Terabe
Vasudevaraju Padmaraju,Yogitha Sankla,Rama Rao Malla
Vasudevaraju Padmaraju
γδ T cells signify a foundational group of immune cells that infiltrate tumors early on, engaging in combat against cancer cells. The buildup of γδ T cells as cancer advances underscores their significance. Initially, these cells infilt...
PM2.5: Epigenetic Alteration in Lung Physiology and Lung Cancer Pathogenesis [0.03%]
PM2.5：对肺生理和肺癌发病机制的表观遗传改变
Tamanna Parida,Gopamma Daka,Deepthi Murapala et al.
Tamanna Parida et al.
Particulate matter (PM) has a very negative impact on human health, specifically the respiratory system. PM comes in many forms, among these is PM2.5,which is a major risk factor for lung cancer and other cardiovascular diseases. PM is inhe...
Gamma Delta T Cells: Role in Immunotherapy of Hepatocellular Carcinoma [0.03%]
gamma delta T细胞在肝癌免疫治疗中的作用
Krishna Chaitanya Amajala,Indu Priya Gudivada,Rama Rao Malla
Krishna Chaitanya Amajala
The most typical type of liver cancer or hepatocellular carcinoma (HCC) develops from hepatocyte loss. Non-alcoholic fatty liver disease (NAFLD), viral hepatitis C and cirrhosis are the leading causes of HCC. With the Hepatitis B vaccine an...