Review Article: Efficacy and Safety of JNK Inhibitors in Cancer Therapy [0.03%]
janus激酶抑制剂在癌症治疗中的疗效和安全性评价评论文章
Lakkakula Suhasini Sahithi,Poojith Nuthalapati,Mohammed Faiz Hussain et al.
Lakkakula Suhasini Sahithi et al.
The c-Jun N-terminal protein kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family. JNK1, JNK2, and JNK3 are three isoforms encoded by distinct genes. JNK signaling controls a variety of biological functions, such...
Review Article: Immunotherapy for Pediatric Malignancies: Benefits and Beyond [0.03%]
儿科恶性肿瘤免疫治疗的利弊及其他评论文章
Soumya Syamala Krishnan,Joseph Atia Ayariga,Nidhi Prakash et al.
Soumya Syamala Krishnan et al.
Investigating factors for childhood malignancies is distinctly more difficult than doing so for adults, as childhood exposure to environmental stimuli, occupational hazards, and age-related geriatric risks is less prevalent. A synergistic a...
Research Article: In Silico Identification of Potential Inhibitors Targeting NUSAP1, A Hub Gene in Hepatocellular Carcinoma [0.03%]
研究论文：通过计算机模拟鉴定针对肝细胞癌中的关键基因NUSAP1的潜在抑制剂
Kotta Dinesh,Indu Priya Gudivada,Krishna Chaitanya Amajala
Kotta Dinesh
Nucleolar-spindle-associated protein 1 (NUSAP1) participates in the assembly of microtubules and the mitotic spindle. Mitotic spindles are microtubule-based structures that segregate chromosomes during mitosis. Its overexpression and knockd...
Research Article: Immunogenic Cell Death-Related Gene Expression Signatures in Breast Cancer Subtypes: A TCGA- and GEO-Based Analysis with Potential Therapeutic Implications [0.03%]
基于TCGA和GEO的乳腺癌亚型免疫原性细胞死亡相关基因表达谱特征分析及潜在治疗意义研究文章
Faustine Marius,Rama Rao Malla
Faustine Marius
Immunogenic cell death (ICD) is a regulated form of cell death that elicits an adaptive immune response, recognized as a promising strategy in cancer immunotherapy. Its therapeutic efficacy, however, can be influenced by tumor-intrinsic fac...
Research Article: The Aromatase Gene rs10046 T>C Polymorphism Does Not Contribute to the Risk of Breast Cancer: A Meta-Analysis [0.03%]
雌激素基因多态性与乳腺癌发病风险无相关性： meta 分析
Manju Patel,Arifullah Mohammed,Mohammad Khairul Azhar Abdul Razab et al.
Manju Patel et al.
Breast cancer is the most common cancer diagnosed in women. Increased exposure to oestrogens is one of the major risk factors for breast cancer. The synthesis of estrogens is mediated by the aromatase enzyme that encoded by CYP19A1 gene. Fu...
Research Article: FKBP4-HSP90 Interaction in Colorectal Cancer: A Novel Therapeutic Target [0.03%]
研究论文：结直肠癌中FKBP4-HSP90相互作用：新的治疗靶点
Yuvasri Golivi,Santosh Kumar Behera,Sujatha Peela et al.
Yuvasri Golivi et al.
Key molecular pathways involved in colorectal cancer (CRC) progression include the activation of the heat shock protein 90 (HSP90) pathway, PI3K/AKT, TP53, and mismatch repair (MMR) pathways. In the current study, we identified that FKBP4 i...
Review Article: CD151 and TGF-β in Colon Cancer Metastasis: Flavonoids and Their Targeted Delivery Systems [0.03%]
综述文章：结肠癌转移中的CD151和TGF-β：类黄酮及其靶向递送系统
Rama Rao Malla,Durga Bhavani Kundrapu,B Priyamavada et al.
Rama Rao Malla et al.
Colon cancer (CC) is the 3rd most prevalent cancer globally, following breast and lung cancer, with the second-highest mortality rate. Multiple risk factors contribute to CC, and metastasis is the primary cause of increased mortality among ...
Riyaz Basha,Ganji Purnachndra Nagaraju
Riyaz Basha
Review Article: Disrupted Oral Microbiota and Its Implications in Cancer Onset and Progression: A Narrative Review [0.03%]
综述文章：口腔微生物群紊乱及其在癌症发生和发展中的作用：叙述性回顾
Giovanni Cultrera,Sabrina Franco,Graziana Spoto et al.
Giovanni Cultrera et al.
The oral microbiota plays a pivotal role in maintaining oral health, but its dysbiosis has been increasingly implicated in the development of systemic diseases, including cancer. Emerging evidence highlights the potential contribution of or...
Review Article: Night Shift Work, Circadian Disruption, and the Gut Microbiome: Implications for Human Health [0.03%]
综述文章：夜班工作、生物钟紊乱和肠道微生物组对人体健康的影响
Silvia Vivarelli,Andrea Marconi,Serena Matera et al.
Silvia Vivarelli et al.
The gut microbiome (GM) plays a critical role in regulating a number of physiological processes within the human host, including metabolism, immune function, and protection from pathogens. Emerging evidence suggests that occupational exposu...